We are so excited to open registration to our summit next week and debut some of the amazing talks and speakers we have lined up. And we are excited that ALS Network is helping be our local host. #EndtheLegacy #GeneticALS #GeneticFTD #c9orf72 #sod1 #fus
StressMarq will be exhibiting at #ADPD2026 from March 17-21 in Copenhagen!📍
Visit us at Booth No. 70 to learn more about our unique products for #Alzheimers & #Parkinsons disease research. 🧠
Learn more 🍁 https://bit.ly/2II2Jeg
#AlphaSynuclein #Tau #AmyloidBeta #TDP43 #TTR #SOD1
We are coming together in Sacramento in March, following other summits in North America in 2024 and 2025. We hope you consider joining us September 24th - 26th in Sacramento CA with local host ALS Network. Registration opening later this month. #EndtheLegacy #c9orf72 #grn #fus #sod1 #tardpb #mapt
StressMarq will be exhibiting at #ADPD2026 from March 17-21 in Copenhagen!📍
Visit us at Booth No. 70 to learn more about our unique products for #Alzheimers & #Parkinsons disease research. 🧠
Learn more 🍁 https://bit.ly/2II2Jeg
#AlphaSynuclein #Tau #AmyloidBeta #TDP43 #TTR #SOD1
StressMarq will be exhibiting at #ADPD2026 from March 17-21 in Copenhagen!📍
Visit us at Booth No. 70 to learn more about our unique products for #Alzheimers & #Parkinsons disease research. 🧠
Learn more 🍁 https://bit.ly/2II2Jeg
#AlphaSynuclein #Tau #AmyloidBeta #TDP43 #TTR #SOD1
🎨Science Visuals |🧠Amyotrophic Lateral Sclerosis (#ALS) is a progressive #neurodegenerative disease marked by the loss of upper & lower motor neurons.
🔬Risk factors: genetic mutations (e.g. #SOD1, #C9orf72, #TDP-43) and environmental triggers (e.g. smoking, pesticides, and heavy metals).
Impaired nucleocytoplasmic transport in #SOD1 -mediated #ALS
Shirel Argueti-Ostrovsky, Su Min Lim...Clotilde Lagier-Tourenne @harvardmed.bsky.social @broadinstitute.org & Adrian Israelson @bengurionuniv.bsky.social #amyotrophiclateralsclerosis
link.springer.com/article/10.1...
[BioRxiv] Divergent TDP43-regulated and TDP43-independent cryptic splicing in the cortex and spinal cord
https://doi.org/10.1101/2024.03.29.587244
#neurodegeneration #biorxiv #ALS #SOD1
[BioRxiv] Superoxide Dismutases maintain niche homeostasis in stem cell populations
https://doi.org/10.1101/2023.12.06.570086
#neurodegeneration #biorxiv #SOD1
Novel in-frame duplication variant of SOD1 in a Japanese family with familial amyotrophic lateral sclerosis.
https://pubmed.ncbi.nlm.nih.gov/41334676/
#neurodegeneration #SOD1
It's Official - MGH in Boston has joined the ranks of those embracing at risk care. We cheer them and all our recognized at risk care centers! See more at EndtheLegacy.org/care #Atrisk #geneticals #c9rof72 #sod1
As promised , linked is our written report for the Genetic ALS and FTD community from NEALS 2024. We will be providing 4 sections with the first debuting today. To read the analysis along with the list visit: https://www.endthelegacy.org/neals-report-2025 #endthelegacy #c9orf72 #sod1 #nealsmtg
Le Dr Maria del Mar Amador est neurologue au Centre SLA de Paris des hôpitaux universitaires de la Pitié-Salpêtrière à Paris.
www.endthelegacy.org/event-details/une-presen... #endthelegacy #sla #c9orf72 #sod1
Nous avons le plaisir de vous annoncer que notre première réunion en français aura lieu le jeudi 25 septembre à 18h, heure de Paris.
Si vous souhaitez pouvoir vous connecter, il faut adresser un mail avec votre demande au : info@endthelegacy.org
#c9orf72 #sod1 #endthelegacy #als #ftd #sla
SOD1, A Crucial Protein for Neural Biochemistry: Dysfunction and Risk of Amyotrophic Lateral Sclerosis.
https://pubmed.ncbi.nlm.nih.gov/40419749/
#neurodegeneration #SOD1
Disease Modification in SOD1-ALS With Tofersen May Result in Serious CNS Inflammation.
https://pubmed.ncbi.nlm.nih.gov/40235273/
#neurodegeneration #SOD1
Association of SOD1 rs36232792 with opioid use disorder and a novel PCR-RFLP method for SOD2 rs5746136.
https://pubmed.ncbi.nlm.nih.gov/40235344/
#neurodegeneration #SOD1
Behavioural effects of oral cannabidiol (CBD) treatment in the superoxide dismutase 1 G93 A (SOD1(G93 A)) mouse model of amyotrophic lateral sclerosis.
https://pubmed.ncbi.nlm.nih.gov/40229540/
#neurodegeneration #SOD1
A polytherapy approach demonstrates therapeutic efficacy for the treatment of SOD1 associated amyotrophic lateral sclerosis.
https://pubmed.ncbi.nlm.nih.gov/40222103/
#neurodegeneration #SOD1
Computational Analysis of SOD1-G93A Mouse Muscle Biomarkers for Comprehensive Assessment of ALS Progression.
https://pubmed.ncbi.nlm.nih.gov/40164574/
#neurodegeneration #biomarker #SOD1
Theoretical evaluation of a bulky ortho-thioalkyl-azobenzene as an alternative to photocontrol structural cytotoxic effects of metal-free and disulfide oxidized hSOD1 in pathogenesis of ALS.
https://pubmed.ncbi.nlm.nih.gov/40129635/
#neurodegeneration #SOD1
🧬 Meet SOD1, a crucial Cu/Zn metalloenzyme that protects cells from oxidative stress. Mutations in SOD1 are linked to a rare form of Amyotrophic Lateral Sclerosis, leading to motor neuron degeneration & paralysis. 🧠⚡ #RareDiseaseThursday #SOD1
Grande nouvelle! Des recherches cliniques menées au Neuro ont permis de valider une thérapie révolutionnaire qui peut ralentir la progression de la #SLA de type #SOD1. #SantéCanada a accordé une approbation conditionnelle au #Tofersen maintenant appelé #Qalsody. Entrevue: bit.ly/qalsodyurc
*This* is why clinical research is vital! A trial run at the CRU led to a breakthrough therapy that allows individuals with #SOD1 #ALS to stabilize their disease and even regain function. #Qalsody has now received conditional approval from Health Canada. #raredisease #tofersen
bit.ly/qalsodyhcan
Photo outside Senator Schiff's office with a staff person we met with.
Photo outside Senator Padilla's office after meeting with a staff person.
Cheers to the organizers and all who participated. The next day we were proud to partner with ALS Network for visits to the CA Senate delegation. We must have our communities voice heard wherever it needs to be! #GeneticALS #GeneticFTD #ALS #FTD #C9orf72 #SOD1 #GRN #EndtheLegacy
