This study employs immunogenic mapping to validate a #TrivalentVaccine strategy providing broad protection against #Sarbecoviruses, offering a scalable framework for pan-virus immunity and future #Pandemic preparedness.
#STTT #OpenAccess: doi.org/10.1038/s413...
#Intranasal #vaccine booster shows stronger immune response and protection against #sarbecoviruses ...
| #immuneresponse | #virus | #mRNA | #vaccine | Via @sciencex.bsky.social
This #STTT study utilizes #Immunogenic relationship mapping to develop a minimal-set trivalent vaccine strategy that elicits broad-spectrum neutralizing antibodies against diverse #Sarbecoviruses and emerging viral threats.
#OpenAccess: doi.org/10.1038/s413...
the study find that the closest-inferred 🦇 virus ancestors of #SARSCoV & #SARSCoV2 existed less than a decade prior to their emergence in humans. Phylogeographic analyses show bat #sarbecoviruses traveled at rates approximating their horseshoe 🦇 hosts & circulated in Asia for millennia.
#Medsky🧪 #IDsky #immunosky #episky #publichealth @cellpress.bsky.social The emergence of #SARSCoV in 2002 a& #SARSCoV2 in 2019 led to increased sampling of #sarbecoviruses circulating in horseshoe 🦇 . Employing phylogenetic inference while accounting for recombination of 🦇 #sarbecoviruses,
#Medsky 🧪 #IDsky #immunosky #publichealth The spike protein of many #sarbecoviruses binds to ACE2 receptor & facilitates viral entry. The diversification of 🦠 spike gene & the mammalian ACE2 gene suggests that s.viruses & their hosts have co-evolved .Another excellent study frim Kei Sato San et al👇🏿
