#Sarcosine and other metabolites along the #choline oxidation pathway in relation to prostate cancer — A large nested case–control study within the JANUS cohort in Norway #B12 #folate #MECFS #LongCovid

bsky.app/profile/rene...

"Figure 1. Choline oxidation pathway and its relation to sarcosine metabolism. The scheme encompasses reactions known to take place in the mammalian liver. Mitochondrial reactions are depicted at the right-hand side of the figure. AdoHcy: S-adenosylhomocys- teine; AdoMet: S-adenosylmethionine; BAD: betaine aldehyde dehydrogenase; Bet: betaine; BHMT: betaine-homocysteine S-methyltransferase; CO: choline oxidase; DD: dimethylglycine dehydro- genase; DMG: dimethylglycine; GCS: glycine cleavage system; Gly: glycine; GNMT: glycine N-methyltransferase; Hcy: homocysteine; Met: methionine; mTHF: 5-methyltetrahydrofolate; MTHF: methyle- netetrahydroflate; MTR: methionine synthase; Sarc: sarcosine (monomethylglycine); SD: sarcosine dehydrogenase; Ser: serine; SHMT: serine hydroxymethyltransferase; THF: tetrahydrofolate."

#Sarcosine and other metabolites along the #choline oxidation pathway in relation to prostate cancer — A large nested case–control study within the JANUS cohort in Norway #B12 #folate #MECFS #LongCovid

bevital.no/pmu/Pages/pa...

Metabolomics Profiling of Critically Ill Coronavirus Disease 2019 Patients: Identification of Diagnostic and Prognostic Biomarkers Coronavirus disease 2019 continues to spread rapidly with high mortality. We performed metabolomics profiling of critically ill coronavirus disease 2019 patients to understand better the underlying pa...

pmc.ncbi.nlm.nih.gov/articles/PMC...

"Feature selection identified the top-performing metabolites for identifying #COVID19 positive patients from healthy control subjects and was dominated by increased #kynurenine and decreased arginine, #sarcosine, and lysophosphatidylcholines." #SARSCoV2

Research reveals new clues to the mysteries of long COVID Researchers at the U of A have pinpointed two proteins that could serve as markers for identifying patients with long COVID — a discovery that may lead to treatments that will bring better quality of ...

Research reveals new clues to the mysteries of #longCOVID

www.ualberta.ca/en/folio/202...

"in a previous study, his team discovered that some #longCOVID patients had a deficiency in two amino acids, #sarcosine and serine, that have anti-inflammatory functions and neuroprotective effects."

Telltale amino acid deficiencies may hold the key to new treatments for long COVID, say researchers A University of Alberta research team brings together immunologists, virologists, rheumatologists and metabolomics experts in an effort to discover exactly what is ailing the sickest long COVID patien...

medicalxpress.com/news/2024-02...

"Finally, the researchers noted significantly lower-than-normal levels of the amino acids #sarcosine, glutamine and serine in the plasma of the #longCOVID patients."

"All three are associated with normal brain function."