Attending WSCC26 in Grindelwald? Let’s connect.

Feb 4–6, the global sodium channel community meets in person. Our Senior Scientist Markus Rapedius will be on site and presenting a poster on APC-based analysis of excitability in ALS iPSC-derived motor neurons (with Axol).

#WSCC26 #SodiumChannels

AChRs and nuclei labeling with α-bungarotoxin (red) and Hoechst (blue), respectively, in fast muscle fibers from control (CT, top) and mutant fish (DM, bottom). Measurements were made on Z-stacks images of whole fibers by dividing each fiber at its equator and applying Z-projection to each half. Z-projections of the upper half of a representative CT and DM fiber are shown (upper panels). Euclidean distance transformation of half-fiber Z-projection generated a distance mapping visualized by colored gradient (lower panels). Bar = 30 µm.

Mammalian #muscle fiber contractions require voltage-gated #SodiumChannels. This study shows that #zebrafish fast muscle fibers don't require Nav channels, suggesting how anatomical & physiological differences from mouse muscles ensure efficient contraction
@plosbiology.org 🧪 plos.io/49BMaOD

AChRs and nuclei labeling with α-bungarotoxin (red) and Hoechst (blue), respectively, in fast muscle fibers from control (CT, top) and mutant fish (DM, bottom). Measurements were made on Z-stacks images of whole fibers by dividing each fiber at its equator and applying Z-projection to each half. Z-projections of the upper half of a representative CT and DM fiber are shown (upper panels). Euclidean distance transformation of half-fiber Z-projection generated a distance mapping visualized by colored gradient (lower panels). Bar = 30 µm.

Mammalian #muscle fiber contractions require voltage-gated #SodiumChannels. This study shows that #zebrafish fast muscle fibers don't require Nav channels, suggesting how anatomical & physiological differences from mouse muscles ensure efficient contraction @plosbiology.org 🧪https://plos.io/49BMaOD

AChRs and nuclei labeling with α-bungarotoxin (red) and Hoechst (blue), respectively, in fast muscle fibers from control (CT, top) and mutant fish (DM, bottom). Measurements were made on Z-stacks images of whole fibers by dividing each fiber at its equator and applying Z-projection to each half. Z-projections of the upper half of a representative CT and DM fiber are shown (upper panels). Euclidean distance transformation of half-fiber Z-projection generated a distance mapping visualized by colored gradient (lower panels). Bar = 30 µm.

Mammalian #muscle fiber contractions require voltage-gated #SodiumChannels. This study shows that #zebrafish fast muscle fibers don't require Nav channels, suggesting how anatomical & physiological differences from mouse muscles ensure efficient contraction @plosbiology.org 🧪https://plos.io/49BMaOD

AChRs and nuclei labeling with α-bungarotoxin (red) and Hoechst (blue), respectively, in fast muscle fibers from control (CT, top) and mutant fish (DM, bottom). Measurements were made on Z-stacks images of whole fibers by dividing each fiber at its equator and applying Z-projection to each half. Z-projections of the upper half of a representative CT and DM fiber are shown (upper panels). Euclidean distance transformation of half-fiber Z-projection generated a distance mapping visualized by colored gradient (lower panels). Bar = 30 µm.

Mammalian #muscle fiber contractions require voltage-gated #SodiumChannels. This study shows that #zebrafish fast muscle fibers don't require Nav channels, suggesting how anatomical & physiological differences from mouse muscles ensure efficient contraction @plosbiology.org 🧪https://plos.io/49BMaOD

⏰ Abstract deadline tomorrow! Join us in Grindelwald, Feb 4–6, 2026 Worldwide Sodium Channel Conference!
Robert Stewart (Harvard) talks on Nav1.8 inhibition & new Nav blockers for pain 💥Accepted abstracts → special issue @jgp.org👉 sodiumchannelconference2026.org
#WSCC26 #SodiumChannels #PainResearch

SCN9A variants are associated with pain disorders.
doi.org/10.1111/epi....

#epilepsy #ILAE #epilepsia #febrileseizures #GEFS+ #geneticepilepsy #SCN9A #sodiumchannels

Differential encoding of mammalian proprioception by voltage-gated sodium channels Voltage-gated sodium channels differentially encode mammalian proprioception via distinct cellular localization patterns.

Check out this article on Voltage-gated sodium channels NaV1.1 and NaV1.6 each play unique and crucial roles in proprioception, shaping motor control and the structure of skeletal muscles #Proprioception #SodiumChannels #MotorFunction www.science.org/doi/10.1126/...

Discovering Suzetrigine: A New Era in Pain Relief Suzetrigine: A Safer Nonopioid Analgesic In the ever-evolving world of pain management, a groundbreaking development has emerged that could change the landscape of treatment for millions of individuals suffering from acute pain. Suzetrigine, the first nonopioid analgesic approved by the FDA in 25 years, is generating excitement among pain specialists like Dr. Brett Stacey, a seasoned expert in the field and a professor of anesthesiology and pain medicine at the University of Washington School of Medicine.

READ FULL ARTICLE ON PAIN ON-LINE: #Suzetrigine #NonopioidAnalgesic #PainManagement #FDAApproval #AcutePain #PainRelief #ClinicalTrials #SodiumChannels #VertexPharmaceuticals #ChronicPain #OpioidAlternatives #PatientSafety #QualityOfLife #InnovativeTreatments #Pain #Medicine #Opioid

1/5 Are you interested in the role of Nav1.9 in AP generation? And what do all the other #sodiumchannels do in the nociceptor? In a study led by the MD student Phil Köster in the lab, we performed manual patch clamp on all Navs known to be expressed in sensory neurons. Nav1.1,2,3,5,6,7,8,9.