Multiomic analyses of longitudinal plasma samples identify thromboinflammation endotypes and trajectories in patients with trauma Analyses of longitudinal plasma samples from patients with trauma identify biological states that determine divergent thromboinflammatory outcomes.

Patients with #trauma can be grouped into one of several “endotypes” based on proteomic and metabolomic profiles that can predict clinical trajectories and the course of #thromboinflammation, according to a new multiomic analysis in #ScienceTranslationalMedicine https://scim.ag/4aqBMcV

Intravital microscopy image of an inflamed blood vessel in the liver of a mouse. A single platelet is attached to the vessel wall and releases a long, thin membrane tether enriched in integrins and tetraspanins, while the platelet body detaches and moves back into the bloodstream.

🥂 Our paper on #platelet derived integrin- and tetraspanin-enriched tethers (PITTs) is out in #Science. 🥳
Non-activated platelets shed αIIbβ3-rich tethers that amplify inflammation while impairing platelet function. Huge thanks to all co-authors!

🔗 doi.org/10.1126/scie...

#ThromboInflammation

Thieme E-Journals - Thrombosis and Haemostasis / Abstract Thieme E-Books & E-Journals

Plus there's more: @thjournal.bsky.social asked us to write a comprehensive update on #immunothrombosis and #thromboinflammation - another fun collab with Christoph Gold and Konstantin Stark @lmumuenchen.bsky.social

www.thieme-connect.com/products/ejo...

www.nature.com/articles/s41...

www.sciencedirect.com/science/arti...

www.neurology.org/doi/full/10....

the findings suggest that #coagulopathy in #COVID is not merely a consequence of inflammation, but rather serves as an apical driver of infection-induced #thromboinflammation & #neuropathology.

Inhibition of transcription factor NFAT activity in activated platelets enhances their aggregation and exacerbates gram-negative bacterial septicemia During gram-negative septicemia, interactions between platelets and neutrophils initiate a detrimental feedback loop that sustains neutrophil extracel…

To go back, always with Valentina, to one of our first loves, NFAT, showing that it plays key roles in #platelets & #thromboinflammation during sepsis! @cp-immunity.bsky.social 8/ www.sciencedirect.com/science/arti...

"With NETs being drivers of #thromboinflammation in #APS, research into disruption of this pathway is underway. 2 #FDA-approved meds w antineutrophilic properties are being studied, as well as selective modulation of #immune cell activity": https://buff.ly/4aF9S9O #research

What I have been saying for years. Cardiovascular events are #immunothrombosis events. Hypertension is an immunological disorder with vascular end-points driven by #thromboinflammation.

Article published days ago
www.nature.com/articles/s41...

1 #Fibrin binds spike protein
2 Forms #proinflammatory #bloodclots
3 Clots drive systemic #thromboinflammation #BrainPathology, incl. #LongCovid
4 #NaturalKiller cell loss increase in #cancer

#Vaccines #spike acts differently
not replicate

Fibrin fuels thromboinflammation and brain damage in COVID-19 Researchers reveal fibrin's critical role in COVID-19 by driving thromboinflammation and neuropathology, and highlight a potential antibody therapy to mitigate these effects.

Fibrin fuels thromboinflammation and brain damage in COVID-19 🔬🧠💉 www.news-medical.net/news/2024082... #COVID19 #Fibrin #Thromboinflammation #Neuropathology #AntibodyTherapy #LongCOVID #ImmuneResponse #Brain #Health #ViralResearch @natureportfolio.bsky.social

Fibrin treibt Thromboinflammation und Neuropathologie bei COVID-19 voran: Ein Durchbruch in der Erforschung neuer Therapieansätze DMZ – WISSENSCHAFT ¦ S. Koller ¦ In einer kürzlich in der renommierten Fachzeitschrift Nature veröffentlichten Studie wurde eine neue spezifische Erkenntnis über die Interaktion von Fibrin und dem SAR...

Fibrin treibt Thromboinflammation und Neuropathologie bei COVID-19 voran: Ein Durchbruch in der Erforschung neuer Therapieansätze www.dmz-news.eu/2024/08/29/f... #Covid19 #Covid_19 #Covid #Corona #Pandemie #Virus #SARSCoV2 #Thromboinflammation #Neuropathologie