Immune exhaustion, the culprit for long COVID and chronic complications Chronic immune exhaustions underlie the development of long COVID.

In their recent News & Views article in #JLB, Shuo Geng & Liwu Li @virginiatech.bsky.social discuss evidence linking #LongCOVID to activation of #Proinflammatory and #ImmuneExhaustion pathways

Two distinct chromatin modules regulate proinflammatory gene expression - Nature Cell Biology Seufert et al. analyse chromatin accessibility to identify sites that open simultaneously in response to TNF. They discover two distinct types of co-accessible regulatory module for controlling the in...

☕ @karsten-rippe.bsky.social & co analyse #chromatin accessibility to identify sites that open simultaneously in response to TNF. They discover 2 distinct types of co-accessible regulatory module for controlling the induction of #proinflammatory gene expression.
👉https://rdcu.be/e2WwS
bit.ly/3MiB4oH

They analyzed the CSF from TBEV patients, focusing on those who progressed to #encephalitis or #meningitis. They found significant differences in #proinflammatory #cytokines and #chemokines between TBEV and control patients, which did not differ between those with meningitis or encephalitis.

New insights into #Hpylori’s virulence machinery 🕵️🧪 Josenhans lab & coll. unravel new interactions between CagT4SS surface proteins and outer membrane proteins HopQ & HopZ—key for host interaction and #proinflammatory signaling. 🦠
@lmumuenchen.bsky.social

👉 buff.ly/toApn0c

Describing the role of #proinflammatory cytokines & CXC chemokines in promoting #BreastCancer (BC) in older women, the impact of post-menopausal #obesity on BC, and the current status of cytokine- & CXC-based #theranostic interventions against BC. #medsky

#MostRead #OpenAccess:
buff.ly/xjcsepe

This review describes the role of #proinflammatory cytokines & CXC chemokines in promoting #BreastCancer (BC) in older women, the impact of post-menopausal #obesity on BC, and the current status of cytokine- & CXC-based #theranostic interventions against BC. #medsky
#OpenAccess:
buff.ly/xjcsepe

In a mouse model of #lung #inflammation induced by endotoxin exposures, direct lung-delivery of #interleukin-10 reduced #proinflammatory mediators and #airway hyperresponsiveness and improved lung compliance.
buff.ly/3XjkbfS
#Fibrosis

The second member we'd like to introduce is Dr. Dake Qi, associate professor at @umanitoba.bsky.social College of Pharmacy. His research interests center around #proinflammatory factors and #insulinresistance, #diabetes, and other #metabolicdysfunctions @chrimanitoba.bsky.social

Day 2 Session 8 #immunotherapystrategies for #neurodegeneratiom kicked off by Dr Stan Appel on #proinflammatory #macrophages & #regulatoryTcells in #neurodegenerative diseases on the amazing effect of #IL2 on #Treg function in #Alzheimer’s then Guillaume Dorothée and Qizhi Tang & Timothy Tree

Article published days ago
www.nature.com/articles/s41...

1 #Fibrin binds spike protein
2 Forms #proinflammatory #bloodclots
3 Clots drive systemic #thromboinflammation #BrainPathology, incl. #LongCovid
4 #NaturalKiller cell loss increase in #cancer

#Vaccines #spike acts differently
not replicate

Viral afterlife: SARS-CoV-2 as a reservoir of immunomimetic peptides that reassemble into proinflammatory supramolecular complexes

Resulting in cooperative, multivalent immune recognition and grossly amplified inflammatory responses.

#longterm #dsRNA #proinflammatory
www.pnas.org/doi/10.1073/...