Deconvolution of the On-Target Activity of Plasmepsin V Peptidomimetics in Plasmodium falciparum Parasites Plasmepsin V (PMV), an essential aspartyl protease, plays a critical role during the asexual blood stage of infection of Plasmodium by enabling the export of parasite proteins into the host red blood ...

Please to share #Sleebs_Lab #WEHI_research latest research led my #Madeline_Dans and #Wenyin_Su demonstrating the on-target activity of plasmepsin V peptidomimetics in Plasmodium falciparum parasites using genetic and proteomic approaches.
pubs.acs.org/doi/10.1021/...

A review of natural products as a source of next-generation drugs against apicomplexan parasites - npj Antimicrobials and Resistance npj Antimicrobials and Resistance - A review of natural products as a source of next-generation drugs against apicomplexan parasites

Please #Sleebs_Lab #WEHI_research has contributed to a review at #npjAMR led by Emma Mao @UniofAdelaide on the contribution of natural products to the drugs approved to treat disease caused by apicomplexan parasites
www.nature.com/articles/s44...

Optimization and Characterization of the Antimalarial Activity of N-Aryl Acetamides that are Susceptible to Mutations in ROM8 and CSC1 New antimalarials are needed due to the threat of emerging resistance against existing antimalarial therapies. A phenotypic screen uncovered the N-aryl acetamide class that inhibits the development of...

Pleased to see our research is published #Sleebs_Lab #WEHI_research led by William Nguyen on the optimization of an antimalarial class that targets ROM8 & CSC1
...stay tuned for more research on the intriguing role of ROM8 & CSC1 in parasite survival...
pubs.acs.org/doi/10.1021/...

I will be at the #ECCB2024 this September. If someone wants to join me in teaching/helping with the #tidyomics #workshop please let me know!

eccb2024.fi/workshops-tu... Together is more fun! :)

#Bioconductor #ECCB2024 #SAiGENCI #WEHI_research