Biochemical insights into the anthelmintic and anti-inflammatory potential of sea cucumber extract: In vitro and in silico approaches Helminthiasis is a global parasitic disease, and current anthelmintics like albendazole are costly, toxic, and increasingly ineffective due to resistance. Marine organisms, such as Holothuria polii ,…

Holothuria polii extract shows potent #anthelmintic and #antiinflammatory activity, surpassing #Albendazole by inducing faster worm paralysis and death. Through #MolecularDocking, they identified strong tubulin-binding compounds.

#OpenAccess in Open Chemistry:

ILC3s promote intestinal tuft cell hyperplasia and anthelmintic immunity through RANK signaling Gut ILC3s help type 2 immunity by boosting tuft cell differentiation.

In the latest #Science #Immunology: researchers @ Tsinghua U report that #ILC3 augment group #ILC2 #anthelmintic immune responses in 🐁! Upon N. braziliensis infection, ILC3-derived #RANKL synergizes w/ #IL13 to facilitate intestinal #TuftCell expansion, which amplifies ILC2 responses!

#medchem #chembio #chemsky #anthelmintic #drugdiscovery #kinase #parasite