Indra, Troyanovsky et al. @feinberg.northwestern.edu show that two δ-catenins, p120 and plakophilin-4, promote distinct #cadherin clustering modes, α-catenin–dependent and α-catenin–independent, respectfully, thereby generating different types of adherens junctions. rupress.org/jcb/article/...
In @jcb.org, Indra, Troyanovsky et al. show that two δ-catenins, p120 and plakophilin-4, promote distinct #cadherin clustering modes, α-catenin–dependent and α-catenin–independent, respectfully, thereby generating different types of adherens junctions. rupress.org/jcb/article/...
The image depicts P-cadherin levels at cell–cell junctions in a planar view of whole-mount preparation of embryonic mouse skin. The image was derived from confocal microscopy data and artistically enhanced for visual clarity. Image credit: Krithika Kalyanakrishnan and Alexandra Jetté
During embryogenesis, how do cells self-organize to support tissue-specific functions? @melanielaurin.bsky.social &co show that ARHGEF3 regulates #cadherin patterning & #placode polarization in early #HairFollicle development, influencing #morphogenesis @plosbiology.org 🧪 plos.io/450aBm5
The image depicts P-cadherin levels at cell–cell junctions in a planar view of whole-mount preparation of embryonic mouse skin. The image was derived from confocal microscopy data and artistically enhanced for visual clarity. Image credit: Krithika Kalyanakrishnan and Alexandra Jetté
During embryogenesis, how do cells self-organize to support tissue-specific functions? @melanielaurin.bsky.social &co show that ARHGEF3 regulates #cadherin patterning & #placode polarization in early #HairFollicle development, influencing #morphogenesis @plosbiology.org 🧪 plos.io/450aBm5
The image depicts P-cadherin levels at cell–cell junctions in a planar view of whole-mount preparation of embryonic mouse skin. The image was derived from confocal microscopy data and artistically enhanced for visual clarity. Image credit: Krithika Kalyanakrishnan and Alexandra Jetté
During embryogenesis, how do cells self-organize to support tissue-specific functions? @melanielaurin.bsky.social &co show that ARHGEF3 regulates #cadherin patterning & #placode polarization in early #HairFollicle development, influencing #morphogenesis @plosbiology.org 🧪 plos.io/450aBm5
Great
@shockjournal
papers describes mechanisms in sepsis vascular permeability #sepsis #edema #cadherin
LACTATE IMPAIRS VASCULAR PERMEABILITY BY INHIBITING HSPA12B ... : Shock journals-lww-com.ezproxy.bu.edu/shockjournal...
Top Left: cdh16 is expressed in the corpuscles of Stannius (CS) during embryonic and larval development. At 120 hpf, cdh16 is expressed in the corpuscles of Stannius (red box). Background signal is observed elsewhere, including in the eyes and head. Bottom left: cdh16 signal is present in the CS and kidney from 48 hpf to 120 hpf, but by 144 hpf cdh16 signal is present in the CS but is no longer detectable in the kidney. Top right: Proposed model. In wild type animals, Cdh16 suppresses stc1l expression in the corpuscles of Stannius. This limits the ability of Stc1l to suppress the function of Papp-aa, allowing for some proliferation and function of ionocytes. As a result, Ca2+ is taken up from the environment and normal acoustic startle thresholds are maintained. Bottom right: In cdh16 mutant animals, suppression of stc1l expression is relieved and stc1l is overexpressed. This results in hyper-inhibition of Papp-aa. As a result, Ca2+ uptake is severely limited, animals are hypocalcemic, and acoustic response thresholds are lowered.
#SensoryGating helps animals to distinguish threatening & non-threatening stimuli. This study reveals a mechanism whereby #cadherin 16 (cdh16)-dependent changes in the corpuscle of Stannius regulate whole-body #calcium homeostasis & sensory gating in #zebrafish @plosbiology.org 🧪 plos.io/4m8XZA2
Top Left: cdh16 is expressed in the corpuscles of Stannius (CS) during embryonic and larval development. At 120 hpf, cdh16 is expressed in the corpuscles of Stannius (red box). Background signal is observed elsewhere, including in the eyes and head. Bottom left: cdh16 signal is present in the CS and kidney from 48 hpf to 120 hpf, but by 144 hpf cdh16 signal is present in the CS but is no longer detectable in the kidney. Top right: Proposed model. In wild type animals, Cdh16 suppresses stc1l expression in the corpuscles of Stannius. This limits the ability of Stc1l to suppress the function of Papp-aa, allowing for some proliferation and function of ionocytes. As a result, Ca2+ is taken up from the environment and normal acoustic startle thresholds are maintained. Bottom right: In cdh16 mutant animals, suppression of stc1l expression is relieved and stc1l is overexpressed. This results in hyper-inhibition of Papp-aa. As a result, Ca2+ uptake is severely limited, animals are hypocalcemic, and acoustic response thresholds are lowered.
#SensoryGating helps animals to distinguish threatening & non-threatening stimuli. This study reveals a mechanism whereby #cadherin 16 (cdh16)-dependent changes in the corpuscle of Stannius regulate whole-body #calcium homeostasis & sensory gating in #zebrafish @plosbiology.org 🧪 plos.io/4m8XZA2
Top Left: cdh16 is expressed in the corpuscles of Stannius (CS) during embryonic and larval development. At 120 hpf, cdh16 is expressed in the corpuscles of Stannius (red box). Background signal is observed elsewhere, including in the eyes and head. Bottom left: cdh16 signal is present in the CS and kidney from 48 hpf to 120 hpf, but by 144 hpf cdh16 signal is present in the CS but is no longer detectable in the kidney. Top right: Proposed model. In wild type animals, Cdh16 suppresses stc1l expression in the corpuscles of Stannius. This limits the ability of Stc1l to suppress the function of Papp-aa, allowing for some proliferation and function of ionocytes. As a result, Ca2+ is taken up from the environment and normal acoustic startle thresholds are maintained. Bottom right: In cdh16 mutant animals, suppression of stc1l expression is relieved and stc1l is overexpressed. This results in hyper-inhibition of Papp-aa. As a result, Ca2+ uptake is severely limited, animals are hypocalcemic, and acoustic response thresholds are lowered.
#SensoryGating helps animals to distinguish threatening & non-threatening stimuli. This study reveals a mechanism whereby #cadherin 16 (cdh16)-dependent changes in the corpuscle of Stannius regulate whole-body #calcium homeostasis & sensory gating in #zebrafish @plosbiology.org 🧪 plos.io/4m8XZA2
