Association between Klotho levels in cerebrospinal fluid and choroid plexus enlargement in neurodegeneration - PubMed In this preliminary study, we observed a strong association between CSF Klotho levels and CP enlargement. Reduced CSF Klotho levels, due to CP dysfunction, may contribute to neurodegeneration. If confirmed in larger cohorts, this association suggests that CSF Klotho may serve as a biomarker for CP e …

📢 New paper published! We show an association between CSF #Klotho levels and #choroidplexus enlargement in #neurodegenerativediseases, supporting CSF Klotho as a potential biomarker of choroid plexus dysfunction and #brainaging.

👉 Read the paper here: pubmed.ncbi.nlm.nih.gov/41393109/

So proud of our 3rd-year MB/PhD student @oscar-baldwin.bsky.social for his great talk at the MB/PhD Symposium on modelling choroid plexus carcinoma 👏🧠🧬✨ #CancerResearch #BrainTumourResearch #ChoroidPlexus #InVivo #invitro @gilbertsonlab.bsky.social @cruk-ci.bsky.social @crukcamcentre.bsky.social

Also thankful for fellowship support from @hhmi.org in my PhD and now from @jcchildsfund.bsky.social!

#Neurodevelopment #Psychedelics #ChoroidPlexus #CSF #DevNeuro #Pregnancy #LSD #Preprint

Beyond the proteins, what other crucial cargo, like lipids or RNAs, are packaged into aposomes? What happens if this secretion is halted? I hope others continue to explore these exciting avenues, and feel free to reach out to discuss! #ChoroidPlexus #ApocrineSecretion

Just us making art out of trying to figure out the white balance on a demo scope! #choroidplexus

Photograph of a woman, Maria K. Lehtinen, PhD, standing at a podium while speaking. Behind her, a large blue slide shows the title of her talk, "Uncovering choroid plexus-CSF contributions to brain development and lifelong brain health." The slide also has a picture of art that resembles the brain cells central to the topic of her talk.

Despite everything else going on in the world, it was incredible to hear Maria Lehtinen's talk on #CSF and #choroidplexus during brain development and sickness today. Many familiar pictures (and videos) from the posts of @scienceyael.bsky.social . Such amazing #neuroscience #neuroimmune research

🔚 Those were my change-of-year picks! What brain barrier research has caught your attention lately? Please share! 🧠✨
#BBB #Meninges #ChoroidPlexus (12/12)

🙎 Choroid plexus organoids derived from ASD patients were also immature.
🔗 Read more: www.sciencedirect.com/science/arti...
#Organoids #ChoroidPlexus #BCSFB (11/12)

Role of immature choroid plexus in the pathology of model mice and human iPSC-derived organoids with autism spectrum disorder During gestation, the choroid plexus (ChP) produces protein-rich cerebrospinal fluid and matures prior to brain development. It is assumed that ChP dy…

4️⃣ Choroid plexus maturation may influence social behaviour.
🐭 A mouse model of immature choroid plexus presents autism spectrum disorder (ASD)-like symptoms.
💊 Metformin promoted choroid plexus maturation and improved social behaviour.
#ChoroidPlexus #ASD (10/12)

11/ Huge thanks to co-authors Alex Hochstetler and Maria K. Lehtinen. The ChP is small but mighty, & we hope this review inspires new research into its pathophysiology and therapeutic promise.

What excites you most about the ChP? Let’s discuss! 🧠✨

#Neuroscience #Pathophysiology #ChoroidPlexus #CSF

#ChoroidPlexus #CerebrospinalFluid #CSF #LongCovid #hEDS

Is this what links The Trifecta? #EDS #POTS #MCAS

Beautiful! Super appreciate your descriptions. I love learning about the #choroidplexus

New paper led by Roberta Magliozzi at the University of Vienna we collaborated. We report #choroidplexus inflammation correlates with #fibrinogen in the CSF & subependymal periventricular areas with #microglia activation in progressive MS.

onlinelibrary.wiley.com/doi/10.1111/...

Potential routes of SARS-CoV-2 entry into the brain via the olfactory pathway. Once SARS-CoV-2 is inhaled into the nasal cavity, the virus spreads to the central nervous system along the retrograde axons of the olfactory nerve via the olfactory epithelial receptors ACE2 and TMPRSS2

Possible pathways by which SARS-CoV-2 enters the brain through other neural invasions. In addition to infection through the olfactory route, SARS-CoV-2 can also be transmitted through direct or indirect contact with the eyes and oral mucosa. SARS-CoV-2 may enter cells through receptors such as ACE2 on the nasal cavity, eyes, respiratory epithelium, lung parenchyma, and gut and in turn affect multiple cranial nerves (including trigeminal, optic, and vagus nerves). SARS-CoV-2 may infect nerve endings, be transported retrogradely, and spread to other brain regions via synapses

Possible mechanism of SARS-CoV-2 infection of the brain via the haematogenous route. Pulmonary infection with SARS-CoV-2 leads to vascular endothelial damage and increase capillary permeability, allowing virus transfer from the lungs to the pulmonary microcirculation. After reaching the BBB, SARS-CoV-2 may enter the CNS through direct interaction with ACE2 receptors or by altering tight junction proteins formed by BBB endothelial cells. Infection with SARS-CoV-2 increases circulating concentrations of proinflammatory cytokines (IL-1, IL-1β, TNF-α, IL-6, IL-12, etc.), thrombin, fibrinogen, and plasmin, and induced hypoxia to disrupt the BBB may lead to paracellular passage of SARS-CoV-2 as a means of entry into the CNS. In addition, infected leukocytes can carry SARS-CoV-2 across the BBB to infect the CNS through a “Trojan horse” mechanism

which together drive microvascular injury & BBB impairment jneuroinflammation.biomedcentral.com/articles/10.... In addition, the blood-cerebrospinal fluid barrier at the #choroidplexus was also impaired after infection..