𝗗𝗡𝗔-𝗣𝗔𝗜𝗡𝗧 𝗺𝗮𝗸𝗲𝘀 𝗺𝘂𝗹𝘁𝗶-𝘁𝗮𝗿𝗴𝗲𝘁 𝗶𝗺𝗮𝗴𝗶𝗻𝗴 𝘀𝗶𝗺𝗽𝗹𝗲𝗿 𝘁𝗵𝗮𝗻 𝘆𝗼𝘂 𝘁𝗵𝗶𝗻𝗸🔬
In #DNAPAINT, target identity is encoded into the DNA sequence, not in the dye.
That means multi-target imaging doesn’t require more optics, just buffer exchange, called Exchange-PAINT. Key advantage: huge multiplexing potential.

Please check out our newest work on fluorogenic speed imager probes, in which we combine the strengths of speed-optimized imagers and fluorogenic imagers.

#SuperResolution #DNAPAINT #microscopy

www.biorxiv.org/content/10.6...

📸 𝗕𝘂𝗶𝗹𝘁 𝘁𝗼 𝗹𝗮𝘀𝘁: The image below was acquired from a Stable Cell Slide after 𝟰 𝗺𝗼𝗻𝘁𝗵𝘀 of storage.

Want to visualize different targets? Ask about a custom Cell slide.

Perfect for demos, training, or getting started with #DNAPAINT!

The molecular basis of force selectivity by PIEZO2 - Nature PIEZO2 is intrinsically more rigid than PIEZO1, and disparate mechanical stimuli paradoxically evoke opposite conformational and gating responses in each channel.

New #MINFLUX paper investigating protein #structuraldynamics:
@ericmulhall.bsky.social @rose-hill.bsky.social @ardemp.bskyverified.social et al used abberior MINFLUX + #DNAPAINT +electrophysiology to investigate ion channel PIEZO2's mechanosensory selectivity.
link.abberior.rocks/piezo2
@scripps.edu

Missed yesterday’s webinar? Watch the recording now 🔬

🎤 Automated DNA-PAINT and Exchange Imaging with Aplo Flow Fluidics!

🎥 Watch the recording: zurl.co/Xqj0a

#DNAPAINT #SuperResolutionMicroscopy #ExchangeImaging #Fluidics

🚀 New app note: Automated high-throughput DNA-PAINT

📄 Download: zurl.co/HaAEh
🎥 Join today's Webinar: zurl.co/GIFcL

#DNAPAINT #SMLM

🚨 Last chance to register!

🎤 Automated DNA-PAINT & Exchange Imaging with Aplo Flow

🗓 March 3
⏰ 10:30AM ET | 3:30PM GMT

See how automated fluidics improves reproducibility & scalability in DNA-PAINT workflows

🔗 zurl.co/HkHEZ

#DNAPAINT #Microscopy #LifeSciences

🚀 𝗔𝗹𝗿𝗲𝗮𝗱𝘆 𝘄𝗼𝗿𝗸𝗶𝗻𝗴 𝘄𝗶𝘁𝗵 (𝗳𝗹𝘂𝗼𝗿𝗲𝘀𝗰𝗲𝗻𝘁) 𝗽𝗿𝗼𝘁𝗲𝗶𝗻-𝘁𝗮𝗴𝘀? Take your imaging to the nanoscale with our 𝗽𝗹𝘂𝗴-𝗮𝗻𝗱-𝗽𝗹𝗮𝘆 𝗗𝗡𝗔-𝗣𝗔𝗜𝗡𝗧 𝗸𝗶𝘁𝘀.

🔬 Available for:
· GFP
· Halo
· RFP
· ALFA
· TagFP
· mEOS

𝗘𝘅𝗽𝗹𝗼𝗿𝗲 𝗸𝗶𝘁𝘀: www.massive-photonics.com/product-cate...

#DNAPAINT #SMLM

New from ONI! 🎉 Learn how #DNAPAINT enables highly multiplexed, quantitative #superresolution imaging below 20 nm, with practical tips to help you get started and choose the right approach for your experiments.

🔗 zurl.co/aaEJ0

New Huisken lab member: We’re excited to welcome Roman Tsukanov (@romantsukanov.bsky.social)! With expertise in super-resolution microscopy using DNA-PAINT, Roman will combine this technology with light sheet fluorescence microscopy. Exciting times ahead!
#SuperResolution #DNApaint #lightsheet #LSFM

Oligomeric assembly of the gatekeeper InvE orchestrates hierarchical type III protein secretion in Salmonella Typhimurium | PNAS Type III secretion systems (T3SS) are critical virulence machines in many Gram-negative bacteria, enabling hierarchical secretion of translocases f...

📄 New paper out!
Please check out our latest publication, where we show how the gatekeeper protein InvE orchestrates hierarchical type III secretion in Salmonella Typhimurium via oligomeric assembly. #T3SS #DNAPAINT

www.pnas.org/doi/10.1073/...

Out now: paper in @natcomms.nature.com applying #DNAPAINT 3D #MINFLUX to study activcation and modulation of the mechano-sensitive ion channel #PIEZO1.

www.nature.com/articles/s41...

Morphological and Hyperphosphorylation Transitions of Nanoscale Tau Aggregates in Alzheimer's Disease Super-resolution microscopy identifies nano-sized tau aggregates (nano-aggregates) and reveals distinct transitions in their morphology and phosphorylation profiles across control, Primary Age-Relate...

𝗧𝗮𝘂 𝗻𝗮𝗻𝗼-𝗮𝗴𝗴𝗿𝗲𝗴𝗮𝘁𝗲 𝘁𝗿𝗮𝗻𝘀𝗶𝘁𝗶𝗼𝗻𝘀 𝗶𝗻 𝗔𝗹𝘇𝗵𝗲𝗶𝗺𝗲𝗿'𝘀 𝗗𝗶𝘀𝗲𝗮𝘀𝗲 𝗿𝗲𝘃𝗲𝗮𝗹𝗲𝗱 𝗯𝘆 𝗗𝗡𝗔-𝗣𝗔𝗜𝗡𝗧

Full study: doi.org/10.1002/advs...

Authors used our anti-mouse and anti-rabbit DNA-PAINT kits for tau visualization in brain tissue sections.

Congratulations to all authors!!

#DNAPAINT #SMLM #MassivePhotonics

🚀 𝗜𝗻𝘁𝗿𝗼𝗱𝘂𝗰𝗶𝗻𝗴 𝗠𝗔𝗦𝗦𝗜𝗩𝗘-𝗥𝗡𝗔-𝗙𝗜𝗦𝗛 𝗣𝗿𝗼𝗯𝗲𝘀 𝗮𝗻𝗱 𝗕𝘂𝗳𝗳𝗲𝗿 𝗞𝗶𝘁𝘀 𝗶𝗺𝗮𝗴𝗶𝗻𝗴 of RNA targets 𝘂𝘀𝗶𝗻𝗴 𝗗𝗡𝗔-𝗣𝗔𝗜𝗡𝗧 𝗺𝗶𝗰𝗿𝗼𝘀𝗰𝗼𝗽𝘆.
🔗: www.massive-photonics.com/product-cate...

#SMLM #DNAPAINT #RNAImaging #RNAFISH #Microscopy #MassivePhotonics

Excited to be the industry partner at King’s SMLM Symposium (26–28 Nov 2025, King’s College London)!

Come explore #STORM, #PALM, #DNAPAINT & #spatialproteomics with the SAFe Platform. Attend our talk on 26 Nov, 11:10 BST.

Register now: estore.kcl.ac.uk/conferences-...

#SMLM #Microscopy

Pushing super-resolution with DNA-PAINT!
The Abbelight Massive Photonics Smart DNA-PAINT Kit makes prep fast, reliable, and high-precision.

Join our webinar on Oct 23 with Prof. Ralf Jungmann, & get a chance to win a kit.

Register here: us06web.zoom.us/webinar/regi...

#DNAPAINT #Microscopy

3D MINFLUX combined with DNA-PAINT resolves the arrangement of Bassoon at active zones Neurotransmitter release and membrane retrieval at active zones require precise spatial and temporal coordination relying on an intricate molecular machinery. However, the exact nano-structural organi...

New pre-print alert! “𝟯𝗗 𝗠𝗜𝗡𝗙𝗟𝗨𝗫 𝗰𝗼𝗺𝗯𝗶𝗻𝗲𝗱 𝘄𝗶𝘁𝗵 𝗗𝗡𝗔-𝗣𝗔𝗜𝗡𝗧 𝗿𝗲𝘀𝗼𝗹𝘃𝗲𝘀 𝘁𝗵𝗲 𝗮𝗿𝗿𝗮𝗻𝗴𝗲𝗺𝗲𝗻𝘁 𝗼𝗳 𝗕𝗮𝘀𝘀𝗼𝗼𝗻 𝗮𝘁 𝗮𝗰𝘁𝗶𝘃𝗲 𝘇𝗼𝗻𝗲𝘀” Congrats to all authors!!

www.biorxiv.org/content/10.1...

#MINFLUX #DNAPAINT #MassivePhotonics #Microscopy #Bassoon

We present a versatile microfluidics platform that makes multiplexed super-resolution imaging more accessible, reproducible, and high-throughput.

👉 BioRxiv: www.biorxiv.org/content/10.1...

#SuperResolution #DNApaint #Microfluidics #SMLM #OpenScience #multiplexing

Don’t forget to come by our booth at #SeeingIsBelieving2025!! We can't wait to chat 🧬 🔬

📍Booth No. 6

#DNAPAINT #SMLM #Superresolution #Microscopy

Join us & Massive Photonics on 23 Oct 2025 (4–5 PM CET) for a webinar with Prof. Ralf Jungmann, KOL on DNA-PAINT!

Discover how single-molecule #SpatialOmics is reshaping #BioImaging.

🎁 Win a Smart DNA-PAINT Kit!

Register now: us06web.zoom.us/webinar/regi...

#DNAPAINT #Microscopy #SMLM

🍬🔬Proteins are so sweet under the microscope .. 🍬🔬

As Möckl RG, for the first time, we image the single-protein glycosylation in native cell state with super-resolution microscopy, map cell-surface glycoproteins, and uncover their spatial organization.

#MöckIRG
#glycotime
#glycoprotein
#dnapaint

🔬 𝗪𝗵𝗶𝗰𝗵 𝗗𝗡𝗔-𝗣𝗔𝗜𝗡𝗧 𝘀𝗲𝗾𝘂𝗲𝗻𝗰𝗲 𝗶𝘀 𝗿𝗶𝗴𝗵𝘁 𝗳𝗼𝗿 𝘆𝗼𝘂?
Our #DNAPAINT Labeling Kits let you choose the balance of 𝘀𝗽𝗲𝗲𝗱 𝗮𝗻𝗱 𝗿𝗲𝘀𝗼𝗹𝘂𝘁𝗶𝗼𝗻 that fits your research.

⭐DNA-PAINT kits: www.massive-photonics.com/product-cate...
⭐FAST DNA-PAINT kits: www.massive-photonics.com/product-cate...

DNA-PAINT and RESI imaging of ALFA-tagged nuclear pore protein Nup96 using the RESI anti-ALFA kit. For RESI imaging, four Exchange-PAINT rounds were performed using a mixture of anti-ALFA single-domain antibodies carrying docking strands F1, F2, F3, and F4 (10,000 frames per round,100 ms integration time, ~ 80 min total imaging time). Image post-processing was carried out using the open-source DNA-PAINT analysis software Picasso's RESI module. For classic DNA-PAINT, all four imager strands were added to the sample simultaneously.

DNA-PAINT and RESI imaging of ALFA-tagged nuclear pore protein Nup96 using the RESI anti-ALFA kit. For RESI imaging, four Exchange-PAINT rounds were performed using a mixture of anti-ALFA single-domain antibodies carrying docking strands F1, F2, F3, and F4 (10,000 frames per round,100 ms integration time, ~ 80 min total imaging time). Image post-processing was carried out using the open-source DNA-PAINT analysis software Picasso's RESI module. For classic DNA-PAINT, all four imager strands were added to the sample simultaneously.

🚀 New Product Launch! 🚀
Ready to push your imaging to 𝘀𝘂𝗯-𝗻𝗮𝗻𝗼𝗺𝗲𝘁𝗲𝗿 𝘀𝗽𝗮𝘁𝗶𝗮𝗹 𝗿𝗲𝘀𝗼𝗹𝘂𝘁𝗶𝗼𝗻? Introducing our newest 𝗥𝗘𝗦𝗜 𝗞𝗶𝘁 𝗳𝗼𝗿 𝗔𝗟𝗙𝗔-𝘁𝗮𝗴𝗴𝗲𝗱 𝗽𝗿𝗼𝘁𝗲𝗶𝗻𝘀!
🔗 www.massive-photonics.com/product-cate...

#SMLM #RESI #DNAPAINT #Microscopy #nuclearpore

Start revealing cellular structures with nanoscale precision today!

#SMLM #Microscopy #DNAPAINT #MassivePhotonics

🚀 New to DNA-PAINT? We make getting started simple.

Check out our 𝗽𝗹𝘂𝗴-𝗮𝗻𝗱-𝗽𝗹𝗮𝘆 #DNAPAINT 𝗹𝗮𝗯𝗲𝗹𝗶𝗻𝗴 𝗮𝗻𝗱 𝗶𝗺𝗮𝗴𝗶𝗻𝗴 𝗸𝗶𝘁𝘀:
✅ Seamless integration into immunostaining workflows
✅ Wide range of kits designed for various targets
✅ Includes all labeling & imaging reagents needed

🔗 massive-photonics.com

📢 Don’t forget to stop by our booth at #SMLMS2025!

We’re excited to share how our #DNAPAINT solutions and labeling kits can help you unlock nanoscale insights 🔬🧬

📍WP Building Foyer, near the windows

📢 We're heading to Single Molecule Localization Microscopy Symposium 2025 in Bonn!

📍 Stop by our booth in the foyer of the WP building to say hello and discuss how our DNA-PAINT kits and solutions enable multiplexed nanoscale imaging.

#SMLM #SMLMS2025 #DNAPAINT

We showcase multiplexed 3D #SMLM imaging of microtubules, vimentin, and actin in U2OS cells 🧬💡

A massive collaborative effort - special thanks to Samrat Basak @samratb.bsky.social for driving the project!

#FLIM #FLPAINT #FLSMLM #MIETPAINT
#DNApaint #MIET #Cytoskeleton

DNA-PAINT samples/images generated using our secondary binder kits: 🔹 Paxillin & Vimentin – Massive-sdAB-FAST 2-Plex Kit 🔹 Tom20 & HSP60 – Massive-AB 2-Plex Kit 🔹 Tom20 – Massive-sdAB 1-Plex Kit 🔹 Tubulin –= Massive-sdAB-FAST 1-Plex Kit AB = antibody | sdAB = single-domain antibody

I𝗺𝗺𝘂𝗻𝗼𝗹𝗮𝗯𝗲𝗹𝗶𝗻𝗴 𝘆𝗼𝘂𝗿 𝘀𝗮𝗺𝗽𝗹𝗲𝘀 𝘂𝘀𝗶𝗻𝗴 𝗽𝗿𝗶𝗺𝗮𝗿𝘆 𝗮𝗻𝘁𝗶𝗯𝗼𝗱𝗶𝗲𝘀? Take your imaging to nanoscale resolution with our 𝗽𝗹𝘂𝗴-𝗮𝗻𝗱-𝗽𝗹𝗮𝘆 𝗗𝗡𝗔-𝗣𝗔𝗜𝗡𝗧 𝘀𝗲𝗰𝗼𝗻𝗱𝗮𝗿𝘆 𝗯𝗶𝗻𝗱𝗲𝗿 𝗸𝗶𝘁𝘀.

🔗 www.massive-photonics.com/product-cate...

#DNAPAINT #SuperResolution #SMLM #Microscopy

🚨 2 × PhD positions @EPFL! 🚨
Help us push the boundaries of fluorescence microscopy - DNA nanotech, custom optics & spatial omics in Lausanne 🇨🇭. Start Jan 2026. Send CV + motivation + 2 refs → fschueder@ethz.ch
#PhD #Hiring #microscopy #SuperResolution #SpatialOmics #DNAPAINT #FLASHPAINT