Pharmacologic activation of autophagy without direct mTOR inhibition as a therapeutic strategy for treating dry macular degeneration #flubendazole #MECFS #LongCovid

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"The benzimidazole derivative #flubendazole is a widely used anthelmintic available over the counter in Europe."

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www.aging-us.com/article/2029...

"In contrast to mTOR inhibitors, these compounds preserved RPE health, and one inducer, the FDA-approved compound #flubendazole (FLBZ), reduced the secretion of apolipoprotein that contributes to extracellular deposits termed drusen."

Pharmacologic activation of autophagy without direct mTOR inhibition as a therapeutic strategy for treating dry macular degeneration | Aging Aging | doi:10.18632/aging.202974. Qitao Zhang, Feriel Presswalla, Robin R. Ali, David N. Zacks, Debra A. Thompson, Jason ML. Miller

Pharmacologic activation of autophagy without direct mTOR inhibition as a therapeutic strategy for treating dry macular degeneration #flubendazole #MECFS #LongCovid

www.aging-us.com/article/2029...

Anthelmintic Drugs as Emerging Immune Modulators in Cancer #flubendazole #STAT3 #MECFS #LongCovid

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www.ncbi.nlm.nih.gov/pmc/articles...

while #flubendazole, which belongs to the benzimidazole family, exerted similar effects on #STAT3, affecting #PD1 expression."

Anthelmintic Drugs as Emerging Immune Modulators in Cancer Despite recent advances in treatment approaches, cancer is still one of the leading causes of death worldwide. Restoration of tumor immune surveillance represents a valid strategy to overcome the acqu...

www.mdpi.com/1422-0067/24...

"In detail, Tao et al. show that #flubendazole inhibits the activation of IκBα kinases (IKK), resulting in decreased phosphorylation of the NF-κB p65 subunit in squamous esophageal carcinoma cells."

Anthelmintic Drugs as Emerging Immune Modulators in Cancer Despite recent advances in treatment approaches, cancer is still one of the leading causes of death worldwide. Restoration of tumor immune surveillance represents a valid strategy to overcome the acqu...

www.mdpi.com/1422-0067/24...

"Another important anthelmintic drug that can target the immune response, even in the context of cancer, is #flubendazole."

Anthelmintic Drugs as Emerging Immune Modulators in Cancer Despite recent advances in treatment approaches, cancer is still one of the leading causes of death worldwide. Restoration of tumor immune surveillance represents a valid strategy to overcome the acqu...

Anthelmintic Drugs as Emerging Immune Modulators in Cancer #flubendazole #STAT3 #MECFS #LongCovid

www.mdpi.com/1422-0067/24...

"The benzimidazole derivative #flubendazole is a widely used anthelmintic available over the counter in Europe."

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The anthelmintic flubendazole blocks human melanoma growth and metastasis and suppresses programmed cell death protein-1 and myeloid-derived suppressor cell accumulation - PubMed The incidence of melanoma is increasing faster than any other cancer. In recent years, treatment of melanoma and a range of other deadly cancers has involved immunotherapy with programmed cell death p...

pubmed.ncbi.nlm.nih.gov/31128215/

"The benzimidazole derivative #flubendazole is a widely used anthelmintic available over the counter in Europe."

Flubendazole induces mitochondrial dysfunction and DRP1-mediated mitophagy by targeting EVA1A in breast cancer Breast cancer is still one of the most common malignancies worldwide and remains a major clinical challenge. We previously reported that the anthelmintic drug flubendazole induced autophagy and apopto...

www.ncbi.nlm.nih.gov/pmc/articles...

"The resultant excessive #mitophagy contributed to mitochondrial damage and dysfunction induced by #flubendazole, thus inhibiting breast cancer cells proliferation and migration."

Fluvermal - Vermifuge Humain Fluvermal est un médicament vermifuge pour éliminer les parasites intestinaux humaines comme les oxyures, les ascaris, les trichocéphales ou les ankylostomes.

Fluvermal ( #flubendazole)

moncoinsante.com/mcs/en/vario...

Fluvermal - Vermifuge Humain Fluvermal est un médicament vermifuge pour éliminer les parasites intestinaux humaines comme les oxyures, les ascaris, les trichocéphales ou les ankylostomes.

Fluvermal ( #flubendazole) (France)

www.pharmaciedesdrakkars.com/fluvermal