Search for the role of a Huc-type [NiFe]-hydrogenase of the soil thermophile Parageobacillus thermoglucosidasius
#microbiology #hydrogenase #hydrogen
@frontiersin.bsky.social
doi.org/10.3389/fmic...

HydSL hydrogenase of Thiocapsa bogorovii may participate in sulfur respiration
#hydrogenase #sulfur
doi.org/10.1016/j.bb...

Correlating Protein Dynamics and Catalytic Activity of a Model Hydrogenase Using Paramagnetic and Biological Nuclear Magnetic Resonance Spectroscopy.
Buchko, Garry W et al.
Paper
Details
#ProteinDynamics #NMR #Hydrogenase

A widespread hydrogenase supports fermentative growth of gut bacteria in healthy people - Nature Microbiology A previously uncharacterized microbial enzyme is responsible for the production of molecular hydrogen in the gut, which drives the growth of other bacteria and has implications for human health.

A widespread hydrogenase supports fermentative growth of gut bacteria in healthy people
#hydrogenase #GutMicrobiome #microbes
@natmicrobiol.nature.com
www.nature.com/articles/s41...

Structural and Spectroscopic Insights into Catalytic Intermediates of a [NiFe]‐hydrogenase from Group 3 Hydrogenases catalyze reversible H2 production and are potential models for renewable energy catalysts. Here, the full redox landscape of a group 3 [NiFe]-hydrogenase from methanothermococcus thermol....

Structural and Spectroscopic Insights into Catalytic Intermediates of a [NiFe]-hydrogenase from Group 3
#hydrogenase #hydrogen
chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/...

Coming up on Thursday, October 23, 2025 🕒 3–4 pm CEST: Online #BeilsteinTalk “Tungsten aldehyde #oxidoreductase – a new type #hydrogenase” with Maciej Szaleniec from the Jerzy Haber Institute of Catalysis and Surface Chemistry Polish Academy of Sciences 🇵🇱 […]

[Original post on hessen.social]

Coming up on Thursday, October 23, 2025 🕒 3–4 pm CEST: Online #BeilsteinTalk “Tungsten aldehyde #oxidoreductase – a new type #hydrogenase” with Maciej Szaleniec from Jerzy Haber Institute of Catalysis and Surface Chemistry, Polish Academy of Sciences 🇵🇱 […]

[Original post on hessen.social]

Save the date: 📅 October 23, 2025 🕒 3–4 pm CEST

Online #BeilsteinTalk “Tungsten aldehyde #oxidoreductase – a new type #hydrogenase” with Maciej Szaleniec from the Polish Academy of Sciences, Krakow 🇵🇱.

Registration is FREE 🔗 […]

[Original post on hessen.social]

Synthesis, Properties, and Electrochemical Proton Reduction of a Homoleptic Tetrathiolato Ni-Site Model of [NiFe]-Hydrogenase | Inorganic Chemistry pubs.acs.org/doi/10.1021/... Harrop and co-workers @InorgChem #nickel #tetrathiolato #NiFe #hydrogenase

Reconstitution of [Fe]-Hydrogenase with Model Complexes Reveals Functional Roles of Methyl Groups in the Metallocofactor While [Fe]-hydrogenase represents a promising biological alternative to noble-metal hydrogenation catalysts, difficulties in its production and genetic manipulation significantly hinder both mechanistic investigations and practical applications. Semisynthetic [Fe]-hydrogenases, assembled from recombinant apoenzymes and synthetic FeGP cofactor mimics, address these limitations, yet early-generation semisynthetic [Fe]-hydrogenases suffer from low activity due to incomplete pyridinol ligand features on the FeGP cofactor mimics. Here, we investigate the roles of 3- and 5-methyl substituents on the FeGP cofactor’s pyridinol ligand by designing and characterizing model complexes 2–4. Reconstitution studies demonstrate that the 3-methyl group boosts catalytic activity (a 35-fold increase over nonmethylated analogs) and reconstitution kinetics, while the 5-methyl group enhances oxidative stability. The optimized variant, jHmd-4, achieves specific activities of 38.5 (forward) and 33.5 U·mg–1 (reverse), reaching 8% of native enzyme activity─the highest reported for semisynthetic systems to date. This breakthrough establishes a tunable platform for developing efficient biohydrogenation catalysts, while providing key insights into metalloenzyme engineering.

Reconstitution of [Fe]-Hydrogenase with Model Complexes Reveals Functional Roles of Methyl Groups in the Metallocofactor
@pubs.acs.org
#chemistry #hydrogen #hydrogenase
pubs.acs.org/doi/10.1021/...

Hydrogenase-Driven Coenzyme Regeneration for Efficient C1 Compound Reduction | Newswise A team of researchers from Beijing Bioprocess Key Laboratory at Beijing University of Chemical Technology, in collaboration with the Institute of Biotechnology at Rheinisch-Westfälische Technische Hoc...

Hydrogenase-Driven Coenzyme Regeneration for Efficient C1 Compound Reduction
www.newswise.com/articles/hyd...
#science #compoundreduction #hydrogenase

📽️ New video: What is a #hydrogenase and how does it work?

🧪 Hydrogenases are very cool biocatalysts that can split hydrogen! #UniSysCat researchers want to learn from it since #hydrogen is the #energy carrier of the future.

➡️ Check out what they already found out: www.youtube.com/watch?v=JqLw...

ISABC 2025 has been an amazing conference full of exciting talks on hydrogenases and bioinorganic chemistry! 🧪⚗️ Inspired by the science and so grateful for the chance to connect with old friends and meet new ones. @kasanmaschefflab.bsky.social @fau.de #ISABC #Hydrogenase #Bioinorganic #Chemistry

Wasserstoffproduzierender und sauerstoffstabiler Biokatalysator renewable-carbon.eu/news/?p=164230 #bakterien #biokatalysator #bioökonomie #enzym #hydrogenase #RenewableCarbon

Oxygen-stable biocatalyst from a thermophilic bacterium could boost hydrogen production In the absence of air, microorganisms produce hydrogen using an enzyme called [FeFe]-hydrogenase, one of the most efficient hydrogen-producing biocatalysts known and a promising tool for green…

Oxygen-stable #biocatalyst from a #thermophilic #bacterium could boost #hydrogen production ...

| #hydrogenase | #microbes | #energy | #Thermosediminibacter | Via @sciencex.bsky.social

Exploring protonation sites with cation-responsive polyethylene glycol (PEG) tethers in [FeFe]-hydrogenase mimics Mimics of [FeFe]-hydrogenases having two [(μ-adt)Fe2(CO)6] moieties linked through 1,2,3-triazole rings with polyethylene glycol (PEG) chains [(–OCH2CH2O–)4 (7) and (–OCH2CH2O–)5 (8)] are able to coor...

🔓Don't miss the #OpenAccess #research article by Miguel A. Sierra et al.
👉Exploring protonation sites with cation-responsive polyethylene glycol (PEG) tethers in [FeFe]- #hydrogenase mimics
#Chemsky #Inorganic #ICF_research
doi.org/10.1039/D5QI...

Vier Forschende nebeneinander auf dem Tempelhofer Feld in Berlin, über ihnen schwebt ein Hydrogenase-Modell.

🔬🔋Enzyme für die #Energiewende: Ein natürliches Molekül könnte helfen, #Wasserstoff als saubere Energiequelle zu nutzen. Im Exzellenzcluster @unisyscat.bsky.social erforschen Wissenschaftler*innen aus der Berlin University Alliance deshalb das Geheimnis der #Hydrogenase.
📷Berlin University Alliance