IN-CODE Symposium 2026: “Inhibitory neurons – from synapses & microcircuits to behavior”.
Join us in Freiburg, Germany, on October 8–9, 2026!!!
Learn more and register here: sfb-trr384.de/symposium/
#neuroscience #interneurons
In this recent study, Felix Preuss et al. observed that inhibitory circuit motifs of cortical #somatosensory layer 5 SST #interneurons are uniform within layers but specific across layers 💡 🔬
📜 Read the #Research here: physoc.onlinelibrary.wiley.com/doi/10.1113/...
Fewer Kv1 channels in the axon initial segment make human neurons easier to activate than mouse neurons. Credit Ádám Tiszlavicz.
How can #neurons fulfil similar roles while exhibiting distinct properties between species? This study shows how geometry & K+ channel expression in the AIS can support rapid #ActionPotentials in human #interneurons, despite slow somatic membrane responses @plosbiology.org 🧪 plos.io/4rONF2G
Fewer Kv1 channels in the axon initial segment make human neurons easier to activate than mouse neurons. Credit Ádám Tiszlavicz.
How can #neurons fulfil similar roles while exhibiting distinct properties between species? This study shows how geometry & K+ channel expression in the AIS can support rapid #ActionPotentials in human #interneurons, despite slow somatic membrane responses @plosbiology.org 🧪 plos.io/4rONF2G
Fewer Kv1 channels in the axon initial segment make human neurons easier to activate than mouse neurons. Credit Ádám Tiszlavicz.
How can #neurons fulfil similar roles while exhibiting distinct properties between species? This study shows how geometry & K+ channel expression in the AIS can support rapid #ActionPotentials in human #interneurons, despite slow somatic membrane responses @plosbiology.org 🧪 plos.io/4rONF2G
Changes in neural selectivity caused by PV cell activation reflect behavioral performance in easy but not difficult discriminations. Left: Optogenetic stimulation timings for entire and early window conditions aligned to stimulus onset (STIM ON) or offset (STIM OFF) (top), schematic of optogenetic method combined with 2-photon imaging (middle), schematic of laser activating only ChrimsonR-expressing PV cells while GCaMP7s reports the activity of all neurons (bottom). Top right: Example frames of in-vivo imaging plane showing GCaMP7s-expressing neurons when illuminated with 920 nm wavelength (left), and ChrimsonR-tdTomato-expressing neurons when illuminated with 1,040 nm wavelength (right). Arrow shows example PV cell. Scale bar, 50 µm. Bottom right: Average response of two example neurons to optogenetic laser illumination during the entire stimulus duration (0–2 s). The activity to the visual stimulus of the identified Pyr cell is suppressed, whereas the PV cell is increased. Shading, SEM.
PV #interneurons provide inhibition to neural circuits, but what's their role in #visual processing? @jasperpoort.bsky.social &co show in mice that activating these neurons during specific task phases & contexts enhances stimulus selectivity & visual discrimination @plosbiology.org 🧪 plos.io/4p3XJmD
Changes in neural selectivity caused by PV cell activation reflect behavioral performance in easy but not difficult discriminations. Left: Optogenetic stimulation timings for entire and early window conditions aligned to stimulus onset (STIM ON) or offset (STIM OFF) (top), schematic of optogenetic method combined with 2-photon imaging (middle), schematic of laser activating only ChrimsonR-expressing PV cells while GCaMP7s reports the activity of all neurons (bottom). Top right: Example frames of in-vivo imaging plane showing GCaMP7s-expressing neurons when illuminated with 920 nm wavelength (left), and ChrimsonR-tdTomato-expressing neurons when illuminated with 1,040 nm wavelength (right). Arrow shows example PV cell. Scale bar, 50 µm. Bottom right: Average response of two example neurons to optogenetic laser illumination during the entire stimulus duration (0–2 s). The activity to the visual stimulus of the identified Pyr cell is suppressed, whereas the PV cell is increased. Shading, SEM.
PV #interneurons provide inhibition to neural circuits, but what's their role in #visual processing? @jasperpoort.bsky.social &co show in mice that activating these neurons during specific task phases & contexts enhances stimulus selectivity & visual discrimination @plosbiology.org 🧪 plos.io/4p3XJmD
Changes in neural selectivity caused by PV cell activation reflect behavioral performance in easy but not difficult discriminations. Left: Optogenetic stimulation timings for entire and early window conditions aligned to stimulus onset (STIM ON) or offset (STIM OFF) (top), schematic of optogenetic method combined with 2-photon imaging (middle), schematic of laser activating only ChrimsonR-expressing PV cells while GCaMP7s reports the activity of all neurons (bottom). Top right: Example frames of in-vivo imaging plane showing GCaMP7s-expressing neurons when illuminated with 920 nm wavelength (left), and ChrimsonR-tdTomato-expressing neurons when illuminated with 1,040 nm wavelength (right). Arrow shows example PV cell. Scale bar, 50 µm. Bottom right: Average response of two example neurons to optogenetic laser illumination during the entire stimulus duration (0–2 s). The activity to the visual stimulus of the identified Pyr cell is suppressed, whereas the PV cell is increased. Shading, SEM.
PV #interneurons provide inhibition to neural circuits, but what's their role in #visual processing? @jasperpoort.bsky.social &co show in mice that activating these neurons during specific task phases & contexts enhances stimulus selectivity & visual discrimination @plosbiology.org 🧪 plos.io/4p3XJmD
On my way to @bernsteinneuro.bsky.social o.bsky.social
Looking forward to a fantastic conference!
p.s. interested in #interneurons #inhibition #oscillations #hippocampus and #dendrites ? Come to meet me on Tuesday's evening poster session!
#bernsteinneuro #bccn #bernsteinconference #bernstein2025
PUBLICATION | Syngap1 regulates the synaptic drive and membrane excitability of Parvalbumin-positive #interneurons in auditory #cortex
elifesciences.org/reviewed-pre...
#MedSky #Neuroskyence
This new work takes the next step: from what (smart dendrites) to why (to control oscillations). A huge thank you to my mentors DietmarSchmitz & Matthew Larkum. Hope this work sparks new ideas & experiments! #Dendrites #Hippocampus #Interneurons #AcademicChatter
Molecular Glue of the Brain: Cell Adhesion Molecules and Synaptic Stability
#Neuroscience #BrainScience #Synapses #NeuronalCircuits #Neuroplasticity #DendriticSpines #Interneurons #CognitiveHealth #Neurobiology #NeuralConnections #Neuropsychiatry #BrainFunction
youtube.com/shorts/dz-Wr...
A new study by Shayna Singh et al. examines properties of rhythmogenic currents in spinal Shox2 #interneurons across #postnatal development 🧠 🔬
📜 Read the #Research here: physoc.onlinelibrary.wiley.com/doi/10.1113/...
2/10 The cortex contains two main classes of neurons: excitatory “go” pyramidal cells and inhibitory “no-go” #interneurons
Congrats to Aurore Gazala for winning the Eve Marder Best Paper Prize for “Subfield-specific interneuron circuits govern the hippocampal response to novelty in male mice” (Nat Comm, 2024) - awarded in person by Eve Marder at the IN-CODE retreat in Potsdam! @acazala.bsky.social #interneurons
Congratulations to Gamze Güney from #mdcBerlin’s Poulet Lab for winning the poster prize at the IN-CODE Retreat in Potsdam! 🏆🧠
Her poster “Thermal encoding by GABAergic interneurons in the posterior insular cortex” impressed with a wealth of data and a clear presentation! #interneurons #neuroscience
Enjoying the IN-Code retreat organized by @mbartos.bsky.social in beautiful Potsdam. Great talks about the impact of interneurons on the neural code. @uni-freiburg.de @biologyunifreiburg.bsky.social @uniklinik-fr.bsky.social #neuroscience #interneurons
🧠 Thrilled that Dietmar Schmitz #Charité joined the latest episode of BRAIN PONDERINGS! 🎙️
Discover how GABAergic #interneurons shape #memory & #brain rhythms in this must-listen episode. 🧬🔬
🎧 Listen now: BRAIN PONDERINGS - Dietmar Schmitz
shorturl.at/D3K65
#Neuroscience #BrainResearch #NeuroCure
Key point: Analysis of cortical samples from HMG patients reveals abnormal development of Pvalb interneurons, which acquire cytomegalic features.
doi.org/10.1111/epi....
#epilepsy #ILAE #corticaldevelopmentaldisorders #interneurons #mTORpathway #neocortex
@physrep.bsky.social
This new paper on effects of pre-operative #sleep fragmentation in mice reports aggravation of post-operative #cognitive dysfunction, with alterations to #hippocampus #interneurons and GABAergic metabolites.
doi.org/10.14814/phy...
#Neurophysiology #Cerebrovascular #Neurons
Our work showing how inhibitory #interneurons of the #hippocampus regulate the #synchrony of pyramidal cell #ensembles is now published in
@plos.bsky.social PLOS Biology
journals.plos.org/plosbiology/...
Summary below👇
