Your Cholesterol Numbers: The Good, the Bad, the Triglycerides A Yale Medicine cardiologist explains how to understand your cholesterol screening numbers.

“ #Lipoprotein (a), or Lp(a), is a sticky, genetically inherited form of bad #cholesterol that contains #LDL. “Over the last decade, we’ve learned that Lp(a) is an independent risk factor for #HeartDisease & #stroke,” Dr. Giaimo says.”: buff.ly/7AbHGU7

from @YaleMed.bsky.social

Lipoprotein apheresis results in plaque stabilization and prevention of cardiovascular events: comments on the prospective Pro(a)LiFe study - Clinical Research in Cardiology Supplements Elevated lipoprotein(a) (Lp(a)) has emerged as an important independent cardiovascular risk factor, and causal association has been accepted with adverse outcome in atherosclerotic disease. Lipoprotei...

Reinhard Klingel from Apherese ForschungsInstitut - AFI | Apheresis Research Institute reporting long term follow up of #lipoprotein #apheresis at the 23rd #apheresis therapy seminar. For more details read the accompanying paper link.springer.com/article/10.1...

🆕 Editor's Choice!

This month's featured paper is on plasma #lipoprotein and #osteoarthritis risk

Lipoprotein subclasses play diverse roles in health and disease there is so much more to learn about its impact on knee #osteoarthritis

Read more from Li et al - www.oarsijournal.com/article/S106...

Nr. 5 September/Oktober 2025 - Gute Pillen - Schlechte Pillen Was bedeutet Lipoprotein für die Herzgesundheit? Welche Wirkstoffe können Schlafstörungen verursachen? Und: Wieso versteckt sich Natrium in Brausetabletten?

Seit gestern ist Heft 5 in diesem Jahr online und auf dem Postweg zu euch🎈Unsere Themen: #Lipoprotein a, #Melatonin, #Grippesaison, #Migräne und vieles mehr. Hier geht´s zu den Artikeln:

A repurposed heart arrhythmia drug shows promise in killing antibiotic-resistant bacteria A new study from Emory University addresses the growing global crisis of antibiotic-resistant infections. Many of these drug-resistant bacteria are spread through hospitals, and there are few…

Repurposed #heart #arrhythmia #drug shows promise in killing #antibiotic-resistant #bacteria ...

| #antibioticresistance | #microbes | #drugresistance | #fendiline | #lipoprotein | Via @sciencex.bsky.social‬

🎉 The HAS Summer School has just kicked off!!
🧑‍🎓Time to dive deep into #lipoprotein metabolism with Prof Alexandros Tselepis and the epidemiology of secondary #dyslipidemias with Prof Demosthenes Panagiotakos!

#HellenicAtherosclerosisSociety #HAS2025

Due to donor shortages, #liver #transplantation may require use of fatty livers. This #proteomic and #lipoprotein profiling study reports on machine # perfusion under #hyperthermia (40 C) as a potential strategy to improve functionality and use of #fattyliver grafts.

Lipoprotein(a) This JAMA Insights discusses lipoprotein(a), including factors associated with elevated lipoprotein(a) levels, how to manage them, and atherosclerotic cardiovascular disease risk.

#Lipoprotein (a)

#CVD @jama.com

jamanetwork.com/journals/jam...

Lepodisiran — A Long-Duration Small Interfering RNA Targeting Lipoprotein(a) | NEJM Elevated lipoprotein(a) concentrations are associated with atherosclerotic cardiovascular disease. The safety and efficacy of lepodisiran, an extended-duration, small interfering RNA targeting hepa...

Lepodisiran, RNA pequeño de interferencia de duración extendida dirigido a la síntesis hepática de lipoproteínas, reduce las concentraciones séricas de lipoproteína(a) entre 60 y 180 d después de su administración #lepodisiran #lipoprotein www.nejm.org/doi/full/10....

what else may one do to improve NMR LDL particle number?
.
on crestor 10, zetia 10
.
#LDL-c went from 193 to 69
.
#cvprev #lipidology #cholesterol #lipoprotein

A study published in Bone Research, provides compelling new evidence of LRP1’s essential role in bone development. The study demonstrates that LRP1 deficiency in skeletal progenitor cells leads to profound skeletal malformations.
#LRP1 #Lipoprotein
Details: doi.org/10.1038/s414...

Oral Muvalaplin for Lowering of Lipoprotein(a) This randomized clinical trial assesses the effect of muvalaplin on lipoprotein(a) concentrations in patients with high baseline lipoprotein(a) levels and cardiovascular risk factors.

Muvalaplin reduce la lipoproteína(a) usando pruebas de lipoproteína(a) intacta y apolipoproteína(a), siendo bien tolerada #muvalaplin #lipoprotein jamanetwork.com/journals/jam...

apo(b) LDL LDLR interface
.
#lipoprotein #ldl #ldl-c #apob #lipidology #medsky #cardiosky

Apolipoprotein B-containing lipoproteins in atherogenesis - Nature Reviews Cardiology In this Review, Borén and colleagues present insights into the role of apolipoprotein B-containing lipoproteins in atherogenesis, with an emphasis on the mechanisms leading to atherosclerotic plaque i...

#apob and atherogenesis

'Subendothelial retention of LDL and other #apolipoprotein B-containing lipoproteins is the primary trigger for the development of atherosclerosis'

#lipids #LDL #lipidology #lipoprotein #cvprev #medsky #lpa

apob < 45 seems appealing

www.nature.com/articles/s41...

image of medical animation using 3d model and scene assets

#Lipid & #Lipoprotein particles attribute to #atherosclerosis and underlying #Cardiovascular #disease. #Medical #animations entirely depend upon #3dmodels and simulations for #science #presentations and marketing collateral of the #pharma & #drug #industries. #3dsmax info@creativesnext.com
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Zerlasiran—A Small-Interfering RNA Targeting Lipoprotein(a) This phase 2 randomized clinical trial evaluates the optimal dose, dosing interval, and safety of zerlasiran, a small-interfering RNA targeting hepatic synthesis of apolipoprotein(a), to treat patient...

Zerlasiran, RNA de interferencia dirigido a síntesis hepática de apolipoproteína(a), es bien tolerada y reduce concentración de lipoproteína(a) en más de 80% durante 36 sem de tratamiento en pacientes con enfermedad CV aterosclerótica #ASCVD #zerlasiran #lipoprotein jamanetwork.com/journals/jam...

Zerlasiran—A Small-Interfering RNA Targeting Lipoprotein(a) This phase 2 randomized clinical trial evaluates the optimal dose, dosing interval, and safety of zerlasiran, a small-interfering RNA targeting hepatic synthesis of apolipoprotein(a), to treat patient...

some have lp(a) > 500 nmol, 6X's more atherogenic, can cause severe aortic calcification and CAD

Zerlasiran reduces #lpa by 80%?

#lipids #lipidology #lipoprotein #cvPrev #cardiosky

jamanetwork.com/journals/jam...

#lipoprotein #lipids #cholesterol #triglycerides #HDL #apob

Non-HDL-C should approximate apo(b)
.
i will update when my apo(b) comes back
#lipids #lipidology #HDL #LDL-c #lipoprotein

Lipoprotein(a) and cardiovascular disease One in five people are at high risk for atherosclerotic cardiovascular disease and aortic valve stenosis due to high lipoprotein(a). Lipoprotein(a) concentrations are lowest in people from east Asia, ...

check #lpa at menopause!

'Concentrations are more than 90% genetically determined and 17% higher in post-menopausal women than in men'

#lipoprotein #lipids #cardiosky #cvprev

for now, some use rosuvastatin and ezetimibe

www.thelancet.com/journals/lan...

Zerlasiran—A Small-Interfering RNA Targeting Lipoprotein(a) This phase 2 randomized clinical trial evaluates the optimal dose, dosing interval, and safety of zerlasiran, a small-interfering RNA targeting hepatic synthesis of apolipoprotein(a), to treat patient...

Zerlasiran, RNA pequeño de interferencia dirigido a la síntesis hepática de apolipoproteína(a), reduce la concentración de lipoproteína(a) en más del 80% a las 36sem de tratamiento en pacientes con enfermedad CV aterosclerótica jamanetwork.com/journals/jam... ASCVD #zerlasiran #lipoprotein