Permanent Lipid Lowering: Redefining the Analytical Horizon 🧬🩺
Latest in Clinical Chemistry: A roadmap for Laboratory Medicine in the era of CRISPR therapeutics. 🧪✨

#ScienceUpdate #CRISPR #LabMed #Lipidology #Bioengineering #ANGPTL3

The Journal of Clinical Lipidology is growing!📈

Our 2025 CiteScore climbed to 6.8, a reflection of the high-quality research and dedicated community behind every issue.

#Lipidology #ClinicalResearch

We know Inclisiran is a game-changer for lowering LDL. But does it work equally well for Heterozygous (HeFH) and the rare, severe Homozygous (HoFH) form?

doi.org/10.1097/MS9.0000000000002982

#WeiPublications #CardioSky #Lipidology #MedSky #Cardiology #Genetics #Inclisiran #FOAMed

Deferiprone therapy improves the oxidative status of LDL in patients with β-thalassaemia/HbE - Drugs in Context This study assesses the protective effect of deferiprone on the oxidative status of low-density lipoproteins in patients with β-thalassaemia/haemoglobin E.

💊 Deferiprone therapy improves the oxidative status of LDL in patients with β-thalassaemia/HbE

Tran et al.

#drugsincontext #hematology #ldl #lipidology #pharmacology #MedSky #PharmSky @medsky.social @me.pharmsky.app

www.drugsincontext.com/deferiprone-...

Remarkable, groundbreaking progress for cardiometabolic science and medicine!!! #FGF21R #GLP1 #APOC3 #ANGPTL3 #PCSK9 #mAb #siRNA #ASO #CRISPRCas9
Shoutout to ♥️ basic and clinical scientists moving this forward for our patients! @ahascience.bsky.social #AHA25 #PrevCards #Lipidology

🔬 New finding: High Lipoprotein(a) is linked with elevated arachidonic acid levels.

Read more 👉 https://ow.ly/uIF950XcOJz

#CardioResearch #LipoproteinA #Lipidology #CardioSky #MedSky

📖 Read the full paper here:
🔗 www.jacc.org/doi/10.1016/...

👏 Huge credit to all INTERASPIRE Investigators for this global contribution to cardiovascular prevention!

#LipoproteinA #Lp_a #CVDPrevention #CardioTwitter #Lipidology #JACC #GlobalHealth

CE Breakfast Symposium at #NLASessions

Excited to be a part of #NLASessions! We're bringing an exciting #CE breakfast symposium on CETP inhibitors on Fri 5/30. Register here: vindicoce.com/NLA

#ASCVD #lipid #lipidology #cardiovasculardisease #dyslipidemia #MedSky @nationallipid @Lipidjournal @Foundationofnla @erinmichos.bsky.social

@drmarthagulati.bsky.social @erinmichos.bsky.social

i am thinking LDL particle number elevation, including elevated small particle number, will increase plaque formation still, 38yo female, exercises, normal weight, +family hx cvd

#cvprev #lipids #ldl-c #lipidology #womenshearthealth

what else may one do to improve NMR LDL particle number?
.
on crestor 10, zetia 10
.
#LDL-c went from 193 to 69
.
#cvprev #lipidology #cholesterol #lipoprotein

apo(b) LDL LDLR interface
.
#lipoprotein #ldl #ldl-c #apob #lipidology #medsky #cardiosky

Apolipoprotein B-containing lipoproteins in atherogenesis - Nature Reviews Cardiology In this Review, Borén and colleagues present insights into the role of apolipoprotein B-containing lipoproteins in atherogenesis, with an emphasis on the mechanisms leading to atherosclerotic plaque i...

#apob and atherogenesis

'Subendothelial retention of LDL and other #apolipoprotein B-containing lipoproteins is the primary trigger for the development of atherosclerosis'

#lipids #LDL #lipidology #lipoprotein #cvprev #medsky #lpa

apob < 45 seems appealing

www.nature.com/articles/s41...

Role of apolipoprotein B in the clinical management of cardiovascular risk in adults: An Expert Clinical Consensus from the National Lipid Association Summary of key points

'5.
#ApoB and #non-HDL-C stratify atherosclerotic cardiovascular disease (ASCVD) risk more accurately than #LDL-C before and during treatment with lipid-lowering therapy (LLT).
Discordance between apoB and LDL-C, apoB and non-HDL-C... is common' #lipidology
www.lipidjournal.com/article/S193...

Long-Term Cognitive Safety of Achieving Very Low LDL Cholesterol with Evolocumab Concerns persist regarding the cognitive safety of achieving very low levels of low-density lipoprotein (LDL) cholesterol. Although short-term studies are reassuring, the long-term cognitive effect...

ldl-c 30's to 50's

not linked to dementia

#lipidology #cvprev #cardiosky #ldl-c #lipids #cholesterol #lipoproteins

evidence.nejm.org/doi/full/10....

Zerlasiran—A Small-Interfering RNA Targeting Lipoprotein(a) This phase 2 randomized clinical trial evaluates the optimal dose, dosing interval, and safety of zerlasiran, a small-interfering RNA targeting hepatic synthesis of apolipoprotein(a), to treat patient...

some have lp(a) > 500 nmol, 6X's more atherogenic, can cause severe aortic calcification and CAD

Zerlasiran reduces #lpa by 80%?

#lipids #lipidology #lipoprotein #cvPrev #cardiosky

jamanetwork.com/journals/jam...

Non-HDL-C should approximate apo(b)
.
i will update when my apo(b) comes back
#lipids #lipidology #HDL #LDL-c #lipoprotein

NewAmsterdam Pharma Announces Positive Topline Data from Pivotal Phase 3 BROADWAY Clinical Trial Evaluating Obicetrapib in Patients with Atherosclerotic Cardiovascular Disease and/or Heterozygous Fami... -- Achieved primary endpoint of LS mean reduction vs placebo in LDL-C on top of maximally tolerated lipid modifying therapies at day 84 with statistically significant reduction (p0.0001) -- -- 21% obs...

Heterozygous familial hypercholesterolemia ( #HeFH)

phase 3 trial, lowered #LDL-c by another 33%?

10 mg obicetrapib
#cvprev #cardiosky #lipids #lipidology

ir.newamsterdampharma.com/news-release...

Lipoprotein(a) throughout life in women Lipoprotein (a) [Lp(a)] is a lipoprotein with multiple deleterious characteristics and is a recognized cardiovascular (CV) risk factor. The pro-athero…

some women post menopause go on to have an elevated lp(a) even with normal ldl-c and it is missed
.
to me, that is a gigantic, most unfair, inequity #cardiosky #lipids #lpa #lipidology #cvprev
.
one can start here:
www.sciencedirect.com/science/arti...

'Obicetrapib, a unique medication, should get rapid FDA approval to help lower LDL-C, apoB and CV-risk in FH patients' #cvprev #cardiosky #lipidology #ldl-c

NewAmsterdam Pharma Announces Positive Topline Data from Pivotal Phase 3 BROADWAY Clinical Trial Evaluating Obicetrapib in Patients with Atherosclerotic Cardiovascular Disease and/or Heterozygous Fami... -- Achieved primary endpoint of LS mean reduction vs placebo in LDL-C on top of maximally tolerated lipid modifying therapies at day 84 with statistically significant reduction (p0.0001) -- -- 21% obs...

👉Read more: ir.newamsterdampharma.com/news-releases/news-release-details/newamsterdam-pharma-announces-positive-topline-data-pivotal-1

#Cardiology #Lipidology #ASCVD

🚨 Big news in lipidology! 🚨

@newamsterdampharma.bsky.social's Phase 3 BROADWAY trial results for Obicetrapib are in:

✅ 33% LDL-C reduction at day 84 (vs placebo)
✅ 21% reduction in MACE after 1 year

A promising advance for patients with #ASCVD & HeFH!
#Cardiology #Lipidology

learn more about lp(a) by listening to this lecture: #lpa #lipids #CvPrev #lipidology

bsky.app/profile/drli...

Ezetimibe in the management of homozygous familial hypercholesterolaemia Homozygous familial hypercholesterolaemia (HoFH) is a severe lipid disorder leading to accelerated atherosclerotic cardiovascular disease (ASCVD). Thi…

ezetimibe aka zetia,

lowers ldl-c about 19%

in homozygous familial hypercholesterolaemia (HoFH)

#lipids #ldl-c #lipidology #cardiosky
www.sciencedirect.com/science/arti...