JAMA editorial published online April 8, 2026, titled "ApoB and Resilient Cost-Effectiveness of Statin Intensity" by Ankur Pandya, PhD, and Jinyi Zhu, PhD. The article discusses statin therapy and ASCVD prevention.

💬 Editorial: Simulation modeling demonstrates #ApoB-guided statin intensification is cost-effective, identifies more clinically meaningful risk, and aligns with 2026 ACC/AHA guidelines.

ja.ma/4cxddfa

Line graph titled 'Cost-Effectiveness of text@1, Non-HDL-C, and LDL-C Goals for Primary Prevention Lipid-Lowering Therapy'. The graph shows cost-effectiveness acceptability curve with 'Optimal probability strategy, %' on the Y-axis and 'Cost-effectiveness threshold (2025 $/QALY gained)' on the X-axis. Lines represent ApoB goal, Non-HDL-C goal, and LDL-C goal.

A computer simulation found #ApoB-guided intensification of lipid-lowering therapy provides the most QALYs and is highly cost-effective compared to #LDL-C or #nonHDL-C targets.

ja.ma/4cxfzKX

Oral #enlicitide lowered LDL-C, #ApoB, & non-HDL-C more than oral non-statin comparators at day 56 in statin-treated adults with a history of a major #ASCVD event or at increased risk for a first event. https://bit.ly/47Ao7hw

#ACC26 #JACC #PCSK9i #CardioSky

And, always tell patients that we humans have 0 need to eat cholesterol. We synthesize it. We’re healthier when we eat exclusively plants & mushrooms 🌱🍄

… and may never need to worry about our LDL-c levels 😎

#ApoB #HeartDisease #cardiology #prevention #CVD #HDL #LDL #Cholesterol #diet #itsTheDiet

I stopped my heart disease from progressing by addressing these 4 markers through targeted nutrition.
I’ve laid out the full "Root Cause" protocol in my book "Reverse Heart Disease."
Stop guessing. Start healing. 👇
 
#HeartHealth #Lpa #Cholesterol #RootCause #ApoB

www.amazon.in/dp/B0G7SB4QCD?

3️⃣ Homocysteine & hs-CRP: These measure "damage" and "inflammation." High numbers mean your artery walls are "rough" and "scratched," making it easy for cholesterol to stick and build a clog. (4/5)
#HeartHealth #Lpa #Cholesterol #RootCause #ApoB #HeartAttackPrevention #ReverseHeartDisease

2️⃣ ApoB: Don't just weigh your cholesterol (LDL-C); count the particles (ApoB). Think of it as the number of "bullets" aimed at your arteries. The higher the count, the higher the risk. (3/5)
#HeartHealth #Lpa #Cholesterol #RootCause #ApoB #HeartAttackPrevention #ReverseHeartDisease

1️⃣ Lp(a): This is genetic "sticky" cholesterol. Standard statins don’t touch it. If your Lp(a) is high, your blood is more likely to form blockages regardless of your diet. You must know this number. (2/5)
#HeartHealth #Lpa #Cholesterol #RootCause #ApoB #HeartAttackPrevention #ReverseHeartDisease

What is really wrong with the NHS? Is the NHS really in crisis because of money — or because we are asking the wrong question altogether? In this video, I argue that the central failure of the NHS is not underfunding alone, but the way...

Some poor communication here on the topic of statins including in the comments - reply posts such as from the author, who I would otherwise rate highly on tax information, are unevidenced statements. Perhaps it's an oversight but if someone makes a claim they should link the evidence. #medsky #APOb

Soo ... i did actually story board this. You figure out limitations real quick. #apob #aiartstory

How should ApoB and Lp(a) be used as core measures to assess cardiovascular risk?

Join experts Allan Sniderman, George Thanassoulis and Michael Pencina as they unpack the power of these biomarkers – and what they mean for prevention strategies.

Listen now👉 bit.ly/3LjJWcC

#ApoB #LipoproteinA

Beyond cholesterol: linking the conformation of... : Current Opinion in Lipidology tential of apoB-containing lipoproteins varies substantially both between and within lipoprotein classes. Recent studies using high-resolution cryo-electron microscopy, crosslinking mass spectrometry,...

Check our brief view on why apoB conformation matters: journals.lww.com/co-lipidolog...
#apoB #atherosclerosis #LDL #lipoproteins #biochemistry #medsky

Related editorial by Sniderman et al. #apoB #Lp(a) #cardiosky academic.oup.com/eurheartj/ad...
bsky.app/profile/eric...

ApoB-containing lipoproteins: count, type, size, and risk of coronary artery disease AbstractBackground and Aims. Apolipoprotein B concentration reflects the number of atherogenic lipoproteins and is recognized as a key lipid risk marker. W

'Lipid-related atherosclerotic risk is most accurately reflected by the total count of apoB-P and is largely unaffected by the major particle type (VLDL, LDL) or size. Elevated count of Lp(a) adds additional risk'
#apob #lpa apo(b) apolipoprotein b #ldl #cholesterol
academic.oup.com/eurheartj/ad...

ApoB-containing lipoproteins: count, type, size, and risk of coronary artery disease AbstractBackground and Aims. Apolipoprotein B concentration reflects the number of atherogenic lipoproteins and is recognized as a key lipid risk marker. W

🫀 Our new study is now out in #EHJ @escardio.bsky.social

📣 Measuring both #apoB and #LipoproteinA provides the most accurate assessment of cardiovascular risk in primary prevention

doi.org/10.1093/eurh...

over my head
#cvprev #lipids #ldl-c #apob #cholesterol
but i can say keeping apo(b) at 60 for 30+yrs is a wise decision

Measure Apo B If We Believe What We Say About Precision Medicine

#CardioSky #cvPrev #ApoB
www.ahajournals.org/doi/10.1161/...
@ahajournals.bsky.social @erinmichos.bsky.social @psatishmd.bsky.social @drlipid.bsky.social @vietheartpa.bsky.social @michaeldshapiro.bsky.social

apo(b) LDL LDLR interface
.
#lipoprotein #ldl #ldl-c #apob #lipidology #medsky #cardiosky

Heterogeneity of Apolipoprotein B Levels Among Hispanic or Latino Individuals Residing in the US This cohort study describes the distribution of apolipoprotein B (apoB) in the Hispanic Community Health Study/Study of Latinos cohort and characterizes associations of baseline sociodemographic and c...

Una cuarta parte de los individuos de la comunidad latina o hispana de EEUU con riesgo intermedio o alto de enfermedad CV aterosclerótica tienen una apolipoproteína B elevada #apoB #hispanic #latino #ASCVD jamanetwork.com/journals/jam...

Heterogeneity of Apolipoprotein B Levels Among Hispanic or Latino Individuals Residing in the US This cohort study describes the distribution of apolipoprotein B (apoB) in the Hispanic Community Health Study/Study of Latinos cohort and characterizes associations of baseline sociodemographic and c...

Apolipoprotein B levels vary significantly among 16,000+ Hispanic/Latino individuals; associations found with sociodemographic factors and ASCVD risk. #ApoB #HispanicHealth PMID:39745752, JAMA Cardiol 2025 doi.org/10.1001/jama...

Apolipoprotein B-containing lipoproteins in atherogenesis - Nature Reviews Cardiology In this Review, Borén and colleagues present insights into the role of apolipoprotein B-containing lipoproteins in atherogenesis, with an emphasis on the mechanisms leading to atherosclerotic plaque i...

#apob and atherogenesis

'Subendothelial retention of LDL and other #apolipoprotein B-containing lipoproteins is the primary trigger for the development of atherosclerosis'

#lipids #LDL #lipidology #lipoprotein #cvprev #medsky #lpa

apob < 45 seems appealing

www.nature.com/articles/s41...

Role of apolipoprotein B in the clinical management of cardiovascular risk in adults: An Expert Clinical Consensus from the National Lipid Association Summary of key points

'5.
#ApoB and #non-HDL-C stratify atherosclerotic cardiovascular disease (ASCVD) risk more accurately than #LDL-C before and during treatment with lipid-lowering therapy (LLT).
Discordance between apoB and LDL-C, apoB and non-HDL-C... is common' #lipidology
www.lipidjournal.com/article/S193...

Role of apo B in clinical management of CV risk in adults: Expert Clinical Consensus from NLA

#CardioSky #cvPrev #MedSky #apoB
@nationallipid.bsky.social @foundationofnla.bsky.social @lipidjournal.bsky.social @erinmichos.bsky.social @drmarthagulati.bsky.social
www.lipidjournal.com/article/S193...

thank you

for the 'very high' risk category, the target apo(b) is 60 according to image on their website

i would have thought #apob 45 would be more appropriate for that category:

#lipoprotein #lipids #cholesterol #triglycerides #HDL #apob

lp(a) is 6x's more atherogenic albeit small total percentage.

it can be elevated with normal #ldl-c and normal #apob apo(b).

minimum measure once in lifetime

lp(a) can be normal then become elevated after menopause!--causing 'silent' disease

glad 4 specific meds soon #cvprev #lipids #cardiosky

apo(b) 'broadly equivalent to LDL-P because each LDL particle, independent of density, contains exactly one apoB and the vast majority (≥90%) of apoB is carried on LDL particles' apob, #lipids #lipodoligy some believe apob is a better test for ASCVD risk than #ldl-c #apob