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Bottom line:
* mRNA clearance is tempo-tuned to species and env. conditions
* 3′UTR motifs and poly(A) tails govern scalable mRNA decay
* QUANTA provides a quantitative framework to study mRNA turnover (and not just in embryos)
#mRNAdecay #zebrafish #mzt #compbio #devbio

Ribosomes modulate transcriptome abundance via generalized frameshift and out-of-frame mRNA decay Zhang et al. identify a regulatory mechanism for how cells adapt to nutrient scarcity through widespread −1 ribosomal frameshifts, culminating in accelerated mRNA decay. This process, dependent on cod...

#mRNADecay #Ribosome #Frameshift #Scerevisiae #NMD #CodonOptimality
Ribosomes modulate transcriptome abundance via generalized frameshift and out-of-frame mRNA decay: Molecular Cell www.cell.com/molecular-ce...

tRNA modifications tune m6A-dependent mRNA decay tRNA modifications functionally interact with m6A to regulate mRNA decay.

Cool! #m6A #tRNA #mRNADecay #RNA
tRNA modifications tune m6A-dependent mRNA decay: Cell www.cell.com/cell/fulltex...

Interesting!
#mRNADecay #DisorderedRegion #Yeast

Regulation of co-translational mRNA decay by PAP and DXO1 in Arabidopsis - BMC Plant Biology Background mRNA decay is central in the regulation of mRNA homeostasis in the cell. The recent discovery of a co-translational mRNA decay pathway (also called CTRD) has changed our understanding of th...

🚨 New discovery! 🚨 The exoribonuclease DXO1 joins XRN4 in co-translational mRNA decay, a key process in plant development & stress response. 🌱🔬
📖 Read more in #BMCPlantBio: bmcplantbiol.biomedcentral.com/articles/10....
#PlantScience #RNA #Arabidopsis #mRNAdecay

The ribosome as a platform to coordinate mRNA decay Abstract. Messenger RNA (mRNA) homeostasis is a critical aspect of cellular function, involving the dynamic interplay between transcription and decay proce

Exicted to share our latest review in @narjournal.bsky.social on how the ribosome coordinates mRNA decay with a focus on structural advances in the field.

#ribosome #mRNAdecay #translation

The ribosome as a platform to coordinate mRNA decay Abstract. Messenger RNA (mRNA) homeostasis is a critical aspect of cellular function, involving the dynamic interplay between transcription and decay proce

#Ribosome #mRNADecay #RNA

academic.oup.com/nar/article/...

Cytoplasmic mRNA decay and quality control machineries in eukaryotes - Nature Reviews Genetics In this Review, Dowdle and Lykke-Andersen discuss advances in our understanding of the machinery and mechanisms involved in the control of cytoplasmic mRNA decay and comment on implications for the de...

Nice!
#RNAdecay #mRNAdecay #QualityControl #Cytoplasm #RNAsky #RNA

www.nature.com/articles/s41...

Circular RNAs trigger nonsense-mediated mRNA decay Boo and Shin et al. uncover that the EJC deposited onto circRNAs after back-splicing is spatially located near the 3′ UTR of mRNA through circRNA-mRNA interaction. The EJC on circRNA triggers NMD of the mRNA. Mechanistic studies reveal the roles of circNMD in apoptosis and its therapeutic potential for mRNA downregulation.

#circRNA #NMD #EJC #mRNADecay #RNA

www.cell.com/molecular-ce...

Decapping activators Edc3 and Scd6 act redundantly with Dhh1 in post-transcriptional repression of starvation-induced pathways

#mRNA #Decapping #mRNADecay #Translation #Scerevisiae #GeneExpression

elifesciences.org/reviewed-pre...