So far in March, we've featured papers on:

• how inflammatory #ILC2 migrate
• engineering #CAR-TCells to restore #checkpoint sensitivity
• capturing the earliest events of #TCell #development
• how certain dietary antigens recognized by #Tregs help mediate #OralTolerance

New content every week!

Are peanut allergies actually declining? | The-14 New research shows peanut allergies in US infants are declining, likely due to early introduction guidelines, offering hope for preventing severe food allergies

Are peanut allergies actually declining?
#Health #PeanutAllergy #FoodAllergies #HealthResearch #InfantHealth #EarlyIntroduction #AllergyPrevention #USStudy #MedicalNews #The14Media #ChildHealth #OralTolerance #PublicHealth #Allergies
the-14.com/are-peanut-a...

RORγt+ antigen-presenting cells mediate food tolerance - Nature Reviews Immunology Five recent papers identify the RORγt+ antigen-presenting cells that induce food-antigen-specific regulatory T cells and establish food tolerance.

Not one, not two .... but FIVE recent papers highlighting a role for RORgt+ antigen-presenting cells in the gut in establishing tolerance to food antigens
#oraltolerance #immunosky #foodallergy

Identification of antigen-presenting cell–T cell interactions driving immune responses to food The intestinal immune system must concomitantly tolerate food and commensals and protect against pathogens. Antigen-presenting cells (APCs) orchestrate these immune responses by presenting luminal ant...

LIPSTICs-mediated new evidence on the role of APCs in #oraltolerance and how their functions adapt during allostatic conditions such as helminth infection.

Identification of antigen-presenting cell–T cell interactions driving immune responses to food | Science 🧪

www.science.org/doi/10.1126/...

The renaissance of oral tolerance: merging tradition and new insights - Nature Reviews Immunology Oral tolerance describes how the oral administration of harmless antigens (such as dietary proteins) leads to systemic immune unresponsiveness to these antigens. Its failure can lead to conditions suc...

#Oraltolerance
Great review mainly focusing on adults where maintening oral tolerance is important for health www.nature.com/articles/s41...
What about #earlylife, when the induction of oral tolerance is key to #development?
A newborn's perspective on immune response to food
doi.org/10.1111/imr....

Come find me at poster #49 at #ASI2024 if you’re interested in gut #eosinophils and their response to an enteric #Salmonella infection 🐭

Or read about it here: doi.org/10.1128/iai....

& stay tuned, another poster from me coming later this week #oraltolerance 🍳🥜