From drug discovery, to rare disease, to precision oncology and more, at The Festival of Genomics and Biodata you can hear about the areas where proteomics and #proteogenomics are shaping the way life scientists work. Find out more here: hubs.la/Q03JMxrd0 #FOG2026

SpecQuality: A Tool for Reliable Spectral Quality Assessment in Proteomics and Proteogenomics Proteogenomics integrates genomics and mass spectrometry (MS) data to understand complex biological systems, disease mechanisms, and potential biomarkers. However, the high volume and noise in MS data...

SpecQuality: A Tool for Reliable Spectral Quality Assessment in #Proteomics and #Proteogenomics | Journal of the American Society for Mass Spectrometry pubs.acs.org/doi/10.1021/...

PgxSAVy: A tool for comprehensive evaluation of variant peptide quality in proteogenomics – catching the (un)usual suspects Variant peptides resulting from single nucleotide polymorphisms (SNPs) can lead to aberrant protein functions and have translational potential for disease diagnosis and personalized therapy. Variant…

Research: www.csbj.org/article/S200...
Computational and Structural Biotechnology Journal (CSBJ)

#alzheimersresearch #bioinformaticstool #csir #elsevier #india #instituteofgenomicsandintegrativebiology #personalisedmedicine #proteinvariants #proteogenomics #usa

The proteogenomic landscape of the human kidney and implications for cardio-kidney-metabolic health - Nature Medicine Based on 337 human kidney and plasma samples, the authors generate the first kidney pQTL dataset and explore novel risk loci that are relevant for cardio-kidney-metabolic health.

Comprehensive #Proteogenomics (pQTL) of human kidneys discerning genetically regulated protein changes in #KidneyFunction and #CardioKidneyMetabolicDisease (CKM) offer targetable mechanism www.nature.com/articles/s41... @ksusztak.bsky.social‬ #TranslationalScience

A proteogenomic approach to identifying a gene signature associated with HOXB13 G84E carrier status in prostate cancer tumours
Aref, A. T., Balleine, R. L. et al.
Paper
Details
#Proteogenomics #HOXB13G84E #ProstateCancerGenetics

🔬 BioMCP: Open-source MCP server for biomedical research AI - connects to clinical trials, PubMed & genomic variants APIs.
Overview video: youtu.be/bKxOWrWUUhM
#BiomedicalAI #OpenSource #MCP #proteogenomics

🧬 Cracking the code of hidden peptides! moPepGen algorithm unveils molecular mysteries in cancer proteomes. Genomic detective work just got a major upgrade! 🕵️‍♀️ #Proteogenomics #CancerResearch https://emmecola.github.io/genomics-daily

MultiStageSearch: An Iterative Workflow for Unbiased Taxonomic Analysis of Pathogens Using Proteogenomics The global SARS-CoV-2 pandemic emphasized the need for accurate pathogen diagnostics. While genomics is the gold standard, integrating mass spectrometry-based proteomics offers additional benefits. However, current proteomic and genomic reference databases are often biased toward specific taxa, such as pathogenic strains or model organisms, and proteomic databases are less comprehensive. These biases and gaps can lead to inaccurate identifications. To address these issues, we introduce MultiStageSearch, a multistep database search method that combines proteome and genome databases for taxonomic analysis. Initially, a generalist proteome database is used to infer potential species. Then, MultiStageSearch generates a specialized proteogenomic database for precise identification. This database is preprocessed to filter duplicates and cluster identical open reading frames to reduce genomic database biases. The workflow operates independently of strain-level NCBI taxonomy, enabling the identification of strains not represented in existing taxonomies. We benchmarked the workflow on viral and bacterial samples, demonstrating its superior performance in strain-level taxonomic inference compared to existing methods. MultiStageSearch offers a flexible and accurate approach for pathogen research and diagnostics, overcoming incomplete search spaces and biases inherent in reference databases.

New publication alert. :-) We published our new tool MultiStageSearch: An Iterative Workflow for Unbiased Taxonomic Analysis of Pathogens Using Proteogenomics in Journal of Proteome Research pubs.acs.org/doi/10.1021/...

#TeamMassSpec #Bioinformatics #Proteomics #Proteogenomics #Pathogens

Study sheds light on how inherited cancer mutations drive tumor growth – BioNews Central The analysis of the genomes of over 1,000 cancer patients revealed that inherited cancer mutations lead to dysfunctional proteins that disrupt physiological functions, offering insights into individual cancer risk and potential strategies for prevent

A #ProteogenomicAnalysis of over 1,000 #CancerPatients revealed that #inherited #CancerMutations lead to dysfunctional proteins that disrupt physiological functions, providing insights into individual #CancerRisk and strategies for #prevention, #EarlyDetection, and #treatment.
#Proteogenomics

New study finds that germline variants - often overlooked in #cancer care - can shape tumor behavior and influence treatment response.
A step toward truly personalized #oncology. www.mountsinai.org/about/newsro... #PrecisionMedicine #Proteogenomics #Genomics #Genetics @zeynephg.bsky.social

👀 #proteogenomics

Who’s off to Festival of Genomics at the end of Jan? Would be very keen to connect with people into long-read RNA-seq, and proteogenomics! Even better if you’re a virologist too! 🧬🦠
#FOG2025 #omics #transcriptomics #proteomics #proteogenomics #bioinformatics