Comprehensive identification and co-expression analysis of long non-coding RNAs across eight timepoints of <i>Schistosoma mansoni</i> life cycle BACKGROUND Long non-coding RNAs (lncRNAs) are important regulatory molecules that can be...

New insights into #Schistosoma mansoni biology 🧬
Map of long non-coding RNAs across 8 life-cycle stages, reveals dynamic, stage-specific expression & co-expression networks—MSTRG.5305.1 can potentially target MEGs and tetraspanin, essential for juvenile worm survival. www.scielo.br/j/mioc/a/DPW...

The hidden infections that refuse to go away: How household practices can stop deadly diseases A 13-year study led by the Colorado School of Public Health at the University of Colorado Anschutz reveals why a deadly parasitic infection targeted for elimination in China persisted in some areas…

How household practices can stop deadly #diseases ...

| #Infections | #Schistosomiasis | #Schistosoma | By @cuanschutz.bsky.social via @sciencex.bsky.social

We look forward to seeing you all in Glasgow in April! (It is the week of Easter Monday, so please arrange travel with that in mind!). #parasitology #leishmania #ntds #universityofglasgow #parasites #mycology #trypanosoma #malaria #schistosoma #helminths #toxoplasma #cryptosporidium

We look forward to seeing you all in Glasgow in April! (It is the week of Easter Monday, so please arrange travel with that in mind!).
#parasitology #leishmania #ntds #universityofglasgow #parasites #mycology #trypanosoma #malaria #schistosoma #helminths #toxoplasma #cryptosporidium

Comparative Analysis of <i>Schistosoma japonicum</i> from Pairing-to-Sexual Maturation based on iTRAQ Proteomics <div xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="section"> <a class="named-anchor" id="d1446044e209"> <!-- named anchor --> </a> ...

Comparative Analysis of #Schistosoma japonicum from Pairing-to-Sexual Maturation based on iTRAQ Proteomics. Click the link below to read this #open_access article. #one_health #zoonoses #IDSky #Medsky www.scienceopen.com/hosted-docum...

2 major #Schistosoma species in Africa S. mansoni (GI) & S. haematobium (GU)
-Both species are endemic to Madagascar, where S. mansoni in eastern, central, southern regions & S. haematobium predominant in northwest & west coast. Both species coexist in certain irrigated regions

Drs Jia Shen, Xuesong Li, Geoff Hide, Zhao-Rong Lun & Zhongdao Wu review roles of #trogocytosis in parasite–host interactions. #Entamoeba #Naegleria #Trichomonas #Trypanosoma #Schistosoma

authors.elsevier.com/a/1lCOY5Eb1x...

New research article

Population-level impact of mass drug administration against #schistosomiasis with anthelmintic drugs targeting juvenile schistosomes: a modelling study

www.thelancet.com/journals/lan...

#IDSky #ClinMicro #Schistosoma #MDA #OpenAccess #OA

Forum in our February issue: #Schistosoma #mattheei & #zoonotic #schistosomiasis, by @russstothard.bsky.social Alexandra Juhász & Janelisa Musaya. #Hybrid #Praziquantel #OneHealth @lstmnews.bsky.social

www.cell.com/trends/paras...

Drs Akram Da'dara & Patrick Skelly discuss the #enigmatic #heptalaminate #surface #membrane of #intravascular #schistosomes. #Schistosoma #Tegument #Nutrient #Transporter #Ectoenzyme @tuftsvet.bsky.social

authors.elsevier.com/a/1kZ935Eb1x...

In dem dazugehörigen #Interview mit Professorin Dr. Clarissa Prazeres da Costa sprechen wir mit der Münchner Parasitologin über #Schistosomiasis, #Klimawandel und zukünftige Herausforderungen 👉 www.youtube.com/watch?v=r4fc...
#NTDs #Schistosoma #CGHTUM #GlobalHealth #WNTDD

The relationship between expelled eggs, morbidity and age: Implications for current Schistosoma mansoni elimination policies Direct morbidity assessments are rarely included in monitoring and evaluation of Schistosoma mansoni control programmes. Instead, the number of eggs-per-gram (EPG) of faeces is used as a proxy for mor...

One of our PhD students @rivkamlim.bsky.social just submitted her second PhD chapter for publication, check out the preprint. Here she has interesting results on the relationship between #Schistosoma mansoni expelled eggs and morbidity eur02.safelinks.protection.outlook.com?url=https%3A...

Paleoparasitological analysis of a 15th–16th c. CE latrine from the merchant quarter of Bruges, Belgium: Evidence for local and exotic parasite infections | Parasitology | Cambridge Core Paleoparasitological analysis of a 15th–16th c. CE latrine from the merchant quarter of Bruges, Belgium: Evidence for local and exotic parasite infections

#paleparasitology #Schistosoma mansoni eggs found in 15th century latrine www.cambridge.org/core/journal...

I’m new here, so why don’t I show you some of my study animals! 🪱 The little white speck in the foreground is a #cercaria of #Schistosoma, a #parasite infecting hundreds of millions of people, mostly in Africa!
Behind is a #Biomphalaria freshwater snail - it’s intermediate host 🐌

Altered purinergic P2X7 and A2B receptors signaling limits macrophage-mediated host defense in schistosomiasis

www.sciencedirect.com/science/arti... #OpenAccess #ImmunoSky #MicroSky #Schistosoma

New research article in The Lancet Microbe

Epidemiology of periportal fibrosis and relevance of current #Schistosoma mansoni infection within the context of repeated mass drug administration in rural Uganda: a population-based, cross-sectional study

www.thelancet.com/journals/lan...

#IDSky

Nature-Inspired Gallinamides Are Potent Antischistosomal Agents: Inhibition of the Cathepsin B1 Protease Target and Binding Mode Analysis Schistosomiasis, caused by a parasitic blood fluke of the genus Schistosoma, is a global health problem for which new chemotherapeutic options are needed. We explored the scaffold of gallinamide A, a natural peptidic metabolite of marine cyanobacteria that has previously been shown to inhibit cathepsin L-type proteases. We screened a library of 19 synthetic gallinamide A analogs and identified nanomolar inhibitors of the cathepsin B-type protease SmCB1, which is a drug target for the treatment of schistosomiasis mansoni. Against cultured S. mansoni schistosomula and adult worms, many of the gallinamides generated a range of deleterious phenotypic responses. Imaging with a fluorescent-activity-based probe derived from gallinamide A demonstrated that SmCB1 is the primary target for gallinamides in the parasite. Furthermore, we solved the high-resolution crystal structures of SmCB1 in complex with gallinamide A and its two analogs and describe the acrylamide covalent warhead and binding mode in the active site. Quantum chemical calculations evaluated the contribution of individual positions in the peptidomimetic scaffold to the inhibition of the target and demonstrated the importance of the P1′ and P2 positions. Our study introduces gallinamides as a powerful chemotype that can be exploited for the development of novel antischistosomal chemotherapeutics.

#medchem #schistosoma #cathepsin

Nature-Inspired Gallinamides Are Potent Antischistosomal Agents: Inhib. of the Cathepsin B1 Protease Target and Binding Mode Anal. (Mareš) - ACS Infect Dis: doi.org/10.1021/acsi...

@iocbprague.bsky.social

New research article in The Lancet Microbe

Diagnostic tests for human #Schistosoma mansoni and Schistosoma haematobium infection: a systematic review and meta-analysis

www.thelancet.com/journals/lan...

#schistosomiasis #diagnostics #MicroSky #IDSky #OpenAccess #OA

#Schistoscope: An #automated #OpenSource #microscope with #AI for detection of #Schistosoma haematobium #eggs in resource-limited settings:

-based on #RaspberryPi 4, #PiCam & #Arduino

doi.org/10.3390/mi13...
#DIYbio #lab #instruments #NTDs #parasites #imaging #PoC #diagnostics

🎓PhD position available @ihpe_lab with @RonaldoAug and Jérôme Boissier @upvd1

🔬 Unveiling the Dark Secrets of Roommate #Parasites: A Study on the Coinfection of #Plasmodium and #Schistosoma in Murine Models at a #Biological and #Molecular Level

🗓 Deadline: Nov 1, 2023.

x.com/RonaldoAug/sta…

Precioso huevo de #Schistosoma con el miracidio a punto de salir que ha logrado captar esta mañana nuestro residente @daniemmee! 🤩

x.com/cosasdemicro/s…

🔬😍😍😍
@microRyC @ParasiteGal @dios_caballero
#WeLoveParasitology
#Schistosoma
#Bilharziosis