The emergence of the artificial intelligence virtual cell heralds a profound paradigm shift in oncology. This shift moves from traditional reductionist dissection of biological components to a generative, systems-level paradigm.
doi.org/10.59717/j.x...
#oncology #artificialintelligence #VirtualCell

Helmholtz Munich Launches Collaboration on AI-Driven Kidney Disease Research

Mapping the Kidney at Single-Cell Resolution 🤖

#HelmholtzMunich and #Novartis Biomedical Research are launching a four-year collaboration to advance #KidneyDisease research with #AI-driven modeling, #VirtualCell simulations, & large-scale perturbation analysis.

👉 t1p.de/yf554

#CellAtlas

200+ live for our series kickoff! 🚀

Huge thanks to everyone who joined our Virtual Biology Community Meetup yesterday.

Missed it? Catch the replay: 📺 youtu.be/ptMy4yhZT8Q

#virtualbiology #decodingbiology #virtualcell #virtualizeexperiments #aiforbiology #drugdiscovery

🚀 Recursion has been laying the foundation for a virtual cell from day one – including massive-scale, proprietary biological & chemical datasets, AI models & one of the industry’s most powerful supercomputers. Learn about our progress & what's next: www.recursion.com/news/since-i... #virtualcell

🎉 Daniel Cohen, President of Valence Labs (@valenceai.bsky.social),
Recursion’s AI research engine, has been named a “Rising Leader” by Citeline. #TechBio #AI #ML #research #virtualcell

👉Read more: insights.citeline.com/in-vivo/lead...

rbio1-training scientific reasoning LLMs with biological world models as soft verifiers Reasoning Models are typically trained against verification mechanisms in formally specified systems such as code or symbolic math. However, in open domains like biology, we do not generally have acce...

Check out the pre-print here www.biorxiv.org/content/10.1.... Not sure if the other authors beyond @tkaraletsos.bsky.social are on bsky #CellBiology #AI #GeneSky #genomics #VirtualCell

🔥 REGISTER NOW: Westlake Symposium on AI Proteomics & Virtual Cell!
🔗https://docs.qq.com/form/page/DTUxvaW5RSFJBeUx4
🗓️ Oct 8-9, 2025
📍 Westlake University, Hangzhou, China
📧zhuhuinan@westlake.edu.cn
Join global pioneers at the intersection of AI+Life Science! #AIProteomics #VirtualCell #AIinScience

IC50 is a deep rabbit hole On harmonizing data, because ground truth in biology is unlike text

The reason doing #ML in #biology is much harder than doing ML on text is that "ground truth" is very different.
In the post below I'll show you the first 5 things we check when curating one single data point to teach the right idea to the #AI. #compbio #virtualcell

blog.turbine.ai/p/ic50-is-a-...

Tahoe-100M

Single-cell transcriptomic perturbation atlas🤠

~100 M cells
~50 Cancer cell lines/spheroids (any normal cell for toxicity?)
~1100 small-molecule agents
52k cell-drug interactions
Mosaic platform

#OpenScience #VirtualCell
bioRxiv 2025
www.biorxiv.org/content/10.1...

Virtual Cell Challenge: Toward a Turing test for the virtual cell Virtual cells are an emerging frontier at the intersection of artificial intelligence and biology. A key goal of these cell state models is predicting cellular responses to perturbations. The Virtual ...

The big problem with this notion of #VirtualCell www.cell.com/cell/fulltex... is the axiom that a cell is the outcome of the interactions between the genes it harbors. Any cell biologist will tell you that this is empirically wrong. #Cells are masters of their genes not the other way around.

Scaling Large Language Models for Next-Generation Single-Cell Analysis Single-cell RNA sequencing has transformed our understanding of cellular diversity, yet current single-cell foundation models (scFMs) remain limited in their scalability, flexibility across diverse ta...

Glad to see multi-cell, multi-modal model attempted.

C2S-scale extends Cell2Sentences (C2S), a previous #virtualcell model, to 27B parameters, training on a 1B token Multi-modal dataset with a context length of 8192 (this needs to increase too).

www.biorxiv.org/content/10.1...

TEDDY: A Family Of Foundation Models For Understanding Single Cell Biology Understanding the biological mechanism of disease is critical for medicine, and in particular drug discovery. AI-powered analysis of genome-scale biological data hold great potential in this regard. T...

Reflecting on #virtualcell: Given that no cell is an island, what's the chance of inferring biology looking at just a single cell's transcriptome? As a recent preprint (arxiv.org/abs/2503.03485) said, "After all, we do not have healthy or diseased annotations for individual cells." #singlecell

🔗 Read more: academic.oup.com/nar/article/53…
PMID:39778870, Nucleic Acids Res 2025

#CellTypeTree #TreeOfLife #CrossSpecies #evolution #VirtualCell

How to build the virtual cell with artificial intelligence: Priorities and opportunities Advances in AI and omics enable the creation of AI virtual cells (AIVCs)—multi-scale, multimodal neural network models that simulate molecules, cells, and tissues across diverse states. This vision outlines their design and collaborative development, promising to transform biological research through high-fidelity simulations, accelerating discoveries, and fostering interdisciplinary open science collaborations.

The Cell article highlights an ambitious research initiative leveraging #AI to decode complex human biological systems. Another great example of AI reshaping #biomedical research and enabling scientific discoveries once deemed impossible. #CellBiology #VirtualCell #AcademicSky