Distribution and p300/CBP dependency of cis-regulatory elements are encoded by unique combinations of histone lactylation and acetylation www.biorxiv.org/content/10.64898/2026.04...

Run an MD simulation of any protein in the AlphaFold Protein Structure Database using AF-CALVADOS

Thanks to @sobuelow.bsky.social AF-CALVADOS is now on Colab

colab.research.google.com/github/KULL-...

Join us THIS Friday (10th April, 1 pm BST) for our UK Biomolecular Condensate seminar!! 👇👇

Beautiful work showing the power of #smFRET for uncovering the complexities ensembles in biology, this time for #RNA structures during transcription- congratulations @olivierduss.bsky.social !!

My first PhD student‘s, Kavan Gor, paper on 5-color single-molecule imaging of co-transcriptional RNA folding is out in @science.org Advances!

He finds how RNA modification enzymes, antisense oligonucleotides and ribosomal proteins re-route nascent RNA folding.

See more details in EMBL post below!

Our TDP-43-paraspeckle paper is now published in Nature Cell Biology! 🎉

www.nature.com/articles/s41...

A Nature Research Briefing on this study will follow shortly.

Congratulations to joint first authors Rachel, Cara and Ruaridh👍

#paraspeckle #condensates #TDP-43 #ALS

Come join us for the next monthly on-line seminar (10th April, 1 pm BST) aimed to connect the UK Biomolecular Condensate community (all are welcome to come and listen). Kellie Dean and Naoto Hori are presenting! @physicsoflifeuk.bsky.social

Fantastic work from our @sheffielduni.bsky.social friends @tslab.bsky.social !! Great to see this super story finally out!

Paraspeckle condensation is controlled via TDP-43 polymerization and linked to neuroprotection!

www.nature.com/articles/s41...

Excellent work from Tatyana Shelkovnikova Lab in @natcellbio.nature.com in collaboration @embl.org

Using #SingleMolecule imaging we find that TFs:

-boost co-transcriptional #ribosomal #RNA processing!

-their binding #dynamics fundamentally differ for mRNA (transient) versus rRNA #transcription (stable)!

@biorxivpreprint.bsky.social Anastasiia Chaban @embl.org

www.biorxiv.org/content/10.6...

* I am, admittedly, biased

An intrinsically disordered tug of war that fine-tunes acetylation Acetylation of histones and transcriptional regulators modulates gene expression, but how acetyltransferases define target specificity remains puzzling. In Cell Reports, Gelder et al. have shown how i...

Massive thanks to @jhenninger.bsky.social for the thoughtful preview of @katiegelder.bsky.social's recent story on CBP-IDRs. It’s fantastic to see her findings situated in the broader context of one of biology’s most dynamic fields* #IDRs #transcription #condensates www.cell.com/cell-reports...

CBP-IDRs regulate acetylation and gene expression Gelder et al. demonstrate that intrinsically disordered regions (IDRs) with divergent sequence properties maintain a functional balance between positive and negative regulation of CBP condensates. This intramolecular mechanism tunes CBP’s sensitivity to lysine acetylation; its disruption fundamentally alters chromatin binding, histone acetylation, and gene expression.

CBP-IDRs regulate acetylation and gene expression

Congratulations @eddierollins.bsky.social @alicepyne.bsky.social and the team- this is super(coiling) cool!

Pre-print Alert! Naked mole-rats hold secrets to healthy ageing that may be revealed if we can dissect their cellular mechanisms. Led by Fangze Tong (an amazing MPhil student), we report live-cell findings about NMR autophagy.
@phar.cam.ac.uk @psalmotoxin.bsky.social

biorxiv.org/content/10.6...

So excellent to get this work out from our fantastic collaboration with AstraZeneca. This is a great amount of work led by joint-PhD student Noah Hitchcock!

lnkd.in/ejV6QBrQ

Postdoc position:Computational Biophysics of Disordered Proteins, Lindorff-Larsen group, University of Copenhagen, Denmark https://tinyurl.com/REWIRE-PD Deadline May 3rd, 2026

We are hiring a postdoc in computational biophysics and machine learning studies of intrinsically disordered proteins

We aim to study the function of IDPs by combining CG MD, ML and bioinformatics in collaboration with @tanjamittag.bsky.social & @rhp-lab.bsky.social

tinyurl.com/REWIRE-PD

📣 I'm excited to share our latest preprint!

We adapt and characterise a neurosphere-based CNCC differentiation protocol, and demonstrate utility for quantitative phenotyping and craniofacial disease modelling! 🧫

Read about Array-CNCC here:
www.biorxiv.org/content/10.6...

@uoe-igc.bsky.social

Thanks Faraz!

None of the story would have been possible without super collaborators @dozenoaks.bsky.social @timcraggs.bsky.social, and our team @nicola-carruthers.bsky.social @brychanevans.bsky.social and @bose-lab.bsky.social @mcb-sheffield.bsky.social congrats all! 🥂

Huge shout out to the @cp-cellreports.bsky.social editorial team and to our really constructive reviewers. At its best, peer review feels like a collaboration rather than an arduous process. (7/7)

The paper’s evolution reflects our changing ideas, but also the incredible development of tools to dissect IDRs. We were able to ask questions this year that simply weren't possible when we started. 🛠️ (6/7)

These two adjacent IDRs create a balance: one promotes while the other inhibits condensates.

This balance dictates how CBP responds to lysine acetylation. Disrupting these IDRs changes chromatin localisation, histone acetylation, and ultimately deregulates gene transcription. (5/7)

We’ve known CBP forms puncta for years. Using endogenous tagging, we showed these are fluid-like condensates shaped by the sequence properties of IDRs. Surprisingly, despite CBP having multiple disordered regions, most of this behaviour is driven by just two IDRs, working in tandem (4/7)

So what did we find? We know IDRs are crucial, but many proteins (like CBP) are formed of multiple IDRs, and mosaics of IDRs and structured domains.

In these cases, how do these IDRs work together? Do they all do the same thing? What determines their specific function? (3/7)

In its final form, the paper has evolved vastly from the original preprint. We’ve removed thousands of words and added new functional data - including a deep dissection of the complex relationship between #IDRs and lysine #acetylation. (2/7)

Really pleased to share the *final* version of @katiegelder.bsky.social's super work, profiling the functional roles of #IDRs in CBP. Published today 🎉

🔗https://doi.org/10.1016/j.celrep.2026.117109

#IDRs #condensates #transcription #CBP #generegulation #enhancers (1/7)

This looks incredibly useful. We're already using GCE @bose-lab.bsky.social for fluorescent labelling- looking forward to trying it for Kac too *plans new experiments* 🤔

Fantastic to welcome @fariatrypslab.bsky.social for our @mcb-sheffield.bsky.social seminar today. So much cool work on #condensates and #generegulation, and can't get over how awesome #trypanosomes are!

Still get a little buzz of excitement when the article proofs arrive!