π¨ new paper alert π¨
Anatomical connectivity does not always predict functional connectivity in disease β a cautionary tale from the cerebellum
Steady-state Purkinje cell activity has limited predictive power for cerebellar output in disease
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Dmitry Fedorov from @achucarro.bsky.social and colleagues provide new insights into the principles underlying #LHb bursting and propose an idealized multiple-timescale dynamical model to capture these complex #behaviours π§ π¬
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Via a randomized crossover trial, Cameron M. Ehnes from @ualberta.bsky.social et al. examined the effect of #sildenafil on resting and exercise diffusing capacity in trained and untrained individuals π΄ π«
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In an All of Us Research Program analysis, Zachary M. Chan from @pittdeptofmed.bsky.social and colleagues observed that heart rate phase is an indicator of chronotype-relevant #circadian shifts associated with human disease π« ποΈ
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In this recent study, Jingwu Pan from @domucla.bsky.social and colleagues investigated ephaptic coupling and the sourceβsink effect of #cardiac #conduction π« π¬
Read the #Research hereποΈ
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From the group of @j-t-gonzalez.bsky.social (in @jphysiol.bsky.social ): low CHO availability augments exercise-induced ACC phosphorylation (pACC), while CHO ingestion suppresses itβindependent of lipid availability. AMPK unchanged. π¬πββοΈπ¬ physoc.onlinelibrary.wiley.com/doi/10.1113/...
In this recent study, Giulia Tomagra and colleagues observed that Ξ±-Synuclein oligomers slow down action potential firing and enhance #dopamine release by increasing Cav2.2 currents in midbrain dopaminergic #neurons π§ π¬
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Atiyeh Mohammadshirazi et al. observed that #pharmacological manipulation of the immediate effects of spinal trauma in neonatal rats reveals a crucial role for #TRPV4 receptors π¬ π§
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#Oxygen and #glucose supplementation increases rates of linear #growth and cell proliferation in growth-restricted fetal sheep π‘οΈ π
Read the study by Mariangel Varela from @uarizona.bsky.social and colleagues here ποΈ
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Souhail Djebari from @uclm.es and co-authors observed that posterior parietal cortex oscillatory activity reflects persistent spatial #memory impairments induced by early hippocampal #amyloidosis in male mice π§ π
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ποΈ EDITOR'S CHOICEποΈ
Skiles from @utah.edu et al. show that an altered immune cell response and accumulation of senescent macrophages may disrupt tissue remodelling during recovery in aged muscle π¬
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Kevin O. Murray (@colorado.edu) and colleagues present translational studies of chronic #supplementation with a mitochondria-targeted #antioxidant to improve physical function with #ageing βοΈ π
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The latest issue is now liveπ
Featuring cover art from Dowling et al. observing that, when combined with a high-fat diet, exercise drives robust proteomic adaptations in skeletal muscle, resulting in the additive enrichment of mitochondrial proteins
π physoc.onlinelibrary.wiley.com/toc/14697793...
Koen Kole and Maarten H.P. Kole from @nin-knaw.bsky.social observed that robust activity-dependent #mitochondrial calcium dynamics at the #AIS is dispensable for action potential generation π¬ π§
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π£ Call for Papers! π£
On the regulation of #fibroblast function in physiology and disease ποΈ
π Organised by Dr. Mario Manresa
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#Cytokines #Fibroblast #Mesenchymalcells #Metabolites #Regulation
In this recent study of comparable motor unit responses to #strength training in young and older adults, Andrea Casolo and colleagues observed that #ageing does not impair motor #neuron adaptations π§ ποΈ
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'Low-dose lithium, oestrogen deficiency and the sarcoplasmic reticulum: Are they connected?'
Joachim Nielsen from @sdu.dk offers this #Perspective on the recent work of Marcella et al. (2026) π
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In this recent study, Sarah A. Angus from @uwaterloohealth.bsky.social and colleagues observed that females exhibit greater #cardiac volume reductions with expiratory muscle loading during submaximal #exercise compared to males π«
π Read it here:
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Yoshiaki Furusawa and colleagues observed that 6-Methylsulfinylhexyl isothiocyanate activates carbonic anhydrase-dependent HCO3β/H+/Na+/Ca2+ transport via SLC4AsβNHEβNCXβPMCA axis in #odontoblasts π¦· π¬
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#Research by Jackson Derby from @boystown-ihn.bsky.social and colleagues found that #testosterone modulates multispectral oscillatory activity serving performance of #motor sequences in typically developing youth π§ βοΈ
π π physoc.onlinelibrary.wiley.com/doi/10.1113/...
This recent study by Peter McDonald and colleagues observed that dry and humid #heat acclimation induces similar #adaptations and cross-acclimation benefits in trained male cyclists βοΈπ‘οΈ
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'Conflicting adaptations in an inhibitory feedback circuit' π§ π
Gregor A. Bergmann from @sheffielduni.bsky.social et al. observed that #neurons sometimes adapt their activity locally in a way that counteracts broader adaptations in the network ποΈ
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'Vasoactive signalling or vascular remodelling? Sex variances in mechanisms of #cerebrovascular ageing'
Read this recent #JournalClub by Harrison T. Levine & Ian W. Appelbe of @rcsi.bsky.social examining the study by Snow and colleagues βοΈ
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'History #bias and its perturbation of the stimulus representation in the macaque #prefrontal cortex' π§ π»οΈ
Read the #research by Danilo Benozzo and colleagues ποΈ
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Yanping Xu of @osuwexmed.bsky.social and colleagues conducted this study into #gait analysis for functional evaluation in a surgical hindlimb suspension model of muscle #atrophy π»οΈ βοΈ
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'Metabolic adaptation without #microbiome remodelling: Rethinking early hostβmicrobiome dynamics'
Ika N. Kadariswantiningsih, Ruthvika Jayanthi & Ekram Arima present this #JournalClub on the work of Davies et al. (2025)βοΈ
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'Crossing the tipping point: Probing the significance and biological drivers of the #mechanobiological shift from #tendon adaptation to #pathology'
NataΕ‘a Pollak and co-authors discuss the work of Lin et al. (2025) βοΈ
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This recent study by Weijian Chen & Makoto Kanzaki observes that #intramuscular neutrophil-derived immunometabolic niches locally boost #insulin-responsive GLUT4 translocation after muscle contraction π¬ ποΈ
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Michele Nigro, Andrea Montanino & Eduardo Soudah from @cimne.com
present a #computational model for #retinal haemodynamics under gravitational and postural variationsποΈ π»οΈ
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'A therapeutic trade-off: The paradoxical effects of #melatonin treatment on vascular #endothelial function in fetal growth-restricted offspring'
Charlie Ambrose, Greta Trogen & Sanna Darvish from @colorado.edu examine the work of Rock et al. βοΈ
π physoc.onlinelibrary.wiley.com/doi/10.1113/...