Discovery of MARK2 as a physiological kinase for PER2 in the mammalian clock Phosphorylation of PER2 at serine 662 regulates circadian timing, and its serine to glycine G (S662G) mutation causes familial advanced sleep phase syndrome. Liu et al. identify MARK2 as the physiological S662 kinase through biochemical purification. MARK2 stabilizes PER2 to regulate the circadian rhythm, and its loss in mice exhibits phase advancement and period shortening.

Online now! Online now! Discovery of MARK2 as a physiological kinase for PER2 in the mammalian clock #chembiol

De novo design of Ras isoform selective binders Zhang et al. use deep learning-based protein design to create isoform-specific Ras binders that selectively target the disordered C termini. These tools enable precise dissection of Ras isoform functions and uncover distinct Ras dependencies that emerge during RasG12C inhibitor resistance.

Online now! Online now! De novo design of Ras isoform selective binders #chembiol

The March issue of Cell Chemical Biology is now online! Explore the latest research, reviews, and insights in chemical biology. Check it out here: http://dlvr.it/TRb66p

The November issue of Cell Chemical Biology is live! Click here to read: www.cell.com/issue/S2451-...

TRIM28-mediated SUMOylation of G3BP1/2 regulates stress granule dynamics Yuan et al. identify TRIM28 as a key component of stress granules (SGs) using the lcFAX-MS approach established here and define TRIM28-mediated G3BP1/2 SUMOylation as a critical mechanism regulating SG dynamics. TRIM28’s role in regulating SGs, facilitated by lcFAX-MS, provides a promising framework for studying diverse LLPS events.

Online now! Online now! TRIM28-mediated SUMOylation of G3BP1/2 regulates stress granule dynamics #chembiol

STT3A is essential for Wnt signaling and represents a target for cancers driven by RNF43 deficiency Loss of RNF43 leads to aberrant Wnt signaling, promoting aggressive cancers for which effective treatments are lacking. He et al. demonstrate that STT3A is critical for the survival of RNF43-deficient tumors, identifying it as a promising therapeutic target validated through both in vitro and in vivo studies.

Online now! STT3A is essential for Wnt signaling and represents a target for cancers driven by RNF43 deficiency #chembiol

Check out our collection ‪@cp-cellchembiol.bsky.social‬ on molecular mechanism of host-microbiome interaction

Therapeutic targeting of WDR5-MLL1 by EMBOW-derived peptides suppresses leukemia progression Targeting the WDR5-MLL1 interaction offers a promising therapeutic strategy for leukemia. Zhang et al. developed Ac7, an EMBOW-derived peptide that binds WDR5 with nanomolar affinity, disrupts the WDR5-MLL1 interaction, and suppresses leukemia cell growth in vivo with relatively low toxicity.

Online now! Online now! Therapeutic targeting of WDR5-MLL1 by EMBOW-derived peptides suppresses leukemia progression #chembiol

@cp-cellchembiol.bsky.social is now on LinkendIn! Please follow us here: www.linkedin.com/company/1069...

With bsky.app/profile/lewl... we peered into condensates using single fluorogen imaging. Nanoscale hubs form, move, & disassemble on a range of timescales. A structural basis for condensate viscoelasticity. Need to rethink popular ideas. #Condensates≠simple-liquids
www.nature.com/articles/s41...

Calcineurin: An essential regulator of sleep revealed by biochemical, chemical biological, and genetic approaches by Yi Rao and colleagues at @PKU1898, @chinese_brain, Peking-Tsinghua Center for Life Sciences http://dlvr.it/THQXFd

β-hydroxybutyrate is a metabolic regulator of proteostasis in the aged and Alzheimer disease brain by Sidharth S. Madhavan, John Newman @GeriSciDoc, et al at @BuckInstitute @USC @USCLeonardDavis @UCSF @IthacaCollege http://dlvr.it/THQZnx

#Technology Degradome analysis to identify direct protein substrates of small-molecule degraders by @Ma_Jochem, @Krijgsveld_lab, and colleagues at @DKFZ @CeMM_News @UniHeidelberg http://dlvr.it/THQcwD

Covalent targeting of splicing in T cells by Kevin A. Scott, Hiroyuki Kojima, Nathalie Ropek, Ekaterina V. Vinogradova @katenokv and colleagues at @RockefellerUniv @TPCB_NYC @WeillCornell @MSKCancerCenter @scrippsresearch http://dlvr.it/THQfvX

SynPull: An advanced method for studying neurodegeneration-related aggregates in synaptosomes using super-res microscopy by @shekhar7_kedia, Emre Fertan, @JohnDanial15, David Klenerman @KlenermanLab et al. at @Cambridge_Uni http://dlvr.it/THYqLx

Our upcoming #TPD webinar features an intriguing talk "Ub or Not Ub: Decoding Ubiquitin-Dependent and Independent Degradation Pathways" by Itay Koren (Bar-Ilan University). Tomorrow at noon EST - www.danafarbertargetedproteindegradation.org

Interesting talk by Paul Hensbergen from the LUMC at #NPP2025. He talked about his work in collaboration with the @smitslab.bsky.social on studying Clostridioides difficile with (glyco)proteomics. Exciting insights into glyosylation of the flagellum. pubs.acs.org/doi/10.1021/...

Read this insightful Voices where @judith-behnsen.bsky.social and others share their perspectives on how advances in chemical biology approaches provide new opportunities for mechanistic and functional investigation of the microbiome. www.cell.com/cell-chemica...

β-hydroxybutyrate is a metabolic regulator of proteostasis in the aged and Alzheimer disease brain Madhavan et al. identify and characterize the selective regulation of protein solubility by the ketone body β-hydroxybutyrate (βHB) across a range of models. βHB exposure rescues cell-based and C. ele...

Our latest work: a new link between metabolism and proteostasis, relevant to Alzheimer's disease. Out today in Cell Chemical Biology as open access! Stay tuned for more discussion of what we found and what it means... @buckinstitute.bsky.social @cellpress.bsky.social
www.cell.com/cell-chemica...

Read @cp-cellchembiol.bsky.social 's latest Focus Issue on Chemical Biology of the Microbiome here: www.cell.com/issue/S2451-...

Online now! Targeting N-Myc in neuroblastoma with selective Aurora kinase A degraders by @jtang162, @DanHarki, and colleagues at @UMN_MedChem @UMNews @UTHealthSA @HHMINEWS @UCSanDiego http://dlvr.it/THDH9Z

Learn more about Molecular Mechanisms in RNA Biology with this joint collection of the latest Reviews and Perspectives from @CellChemBiol and @MolecularCell http://dlvr.it/TH4dtW

HPV Infections: Friend and Foe

An interesting finding that some types of HPV infection might be preventing cancer (as opposed to the ones that can cause it).

Also features G.K. Chesterton and a brief cameo by RFK Jr.

Computational Care

DiffDock, a new diffusion-based ligand docking program, made s big splash earlier this year. But it’s apparently not all it’s claimed to be:

Thank you @mishtudey.bsky.social and the other organizers for a fantastic symposium. The talks covered broad areas of chemical biology-from targeted protein degradation and molecular glues to sensor development and immuno-oncology. They also represented a nice blend of academic and industry efforts.

Thanks so much for participating and the exciting talk.

Got the chance to put together the "Click of Chemical Biologists" starter pack v1 and v2 over the Thanksgiving Break. Feel free to ping me on who else I might be missing!
V1: go.bsky.app/3P5i7nJ
V2: go.bsky.app/Cr4ej7

First paper of our lab today @natureportfolio.bsky.social by Nussi!

We provide a real-time movie on how #transcription and #translation cooperate using #single-molecule FM: we find long-range #ribosome/ RNAP communication mediated by #RNA looping!

@embl.org #RNAbiology #RNASky

t.co/a24Xxcxdo0

It was a great pleasure to present @CellSymposia #CSchembio2024 our work on intracellular biodegraders in beautiful San Francisco!! Thanks to the organisers for this opportunity! @mariesorbara.bsky.social