Vitamin B2 metabolism promotes FSP1 stability to prevent ferroptosis - Nature Structural & Molecular Biology Here, Deol et al. use genetic screens in gene-edited reporter cell lines to identify regulators of ferroptosis suppressor protein 1 (FSP1) expression and stability. They show that vitamin B2 metabolis...

1/3 Thrilled to see our paper led by Kirandeep Deol is out in Nature Structural & Molecular Biology! CRISPR screens to uncover a role for vitamin B2 metabolism in stabilizing FSP1 via FAD, revealing a new way vitamins regulate ferroptosis.
www.nature.com/articles/s41...

Riboflavin metabolism shapes FSP1-driven ferroptosis resistance - Nature Cell Biology After performing a focused CRISPR–Cas9 screen, Skafar et al. identify riboflavin (vitamin B2) as a regulator of FSP1 stability that modulates phospholipid peroxidation and ferroptosis sensitivity in c...

Happy to share the final version of the study where we describe a central role for vitaminB2 in regulating membrane redox state - some new cool experiments were added since the preprint was posted - pls check this out

thttps://www.nature.com/articles/s41556-025-01856-x

Our preprint "#miR940 suppresses #ferroptosis by controlling expression of key regulatory genes" is now available.

A true collaborative effort 🤩
Thanks to the team and all collaborators.

Full preprint:
www.biorxiv.org/content/10.6...

@helmholtzmunich.bsky.social
@columbiauniversity.bsky.social

Können alte Virusreste Alzheimer auslösen? YouTube video by Alzheimer Forschung Initiative

Dr. Vincendeau @m-vincendeau.bsky.social von @helmholtzmunich.bsky.social untersucht in ihrem AFI-Projekt, welche Virusreste im Erbgut mit Alzheimer in Zusammenhang stehen könnten und welche Mechanismen dadurch ausgelöst werden.

▶️ Mehr Infos zum Projekt gibt es im Video

Können alte Virusreste eine Alzheimer-Erkrankung auslösen? <h3>Was wird erforscht?</h3> <p>Alzheimer ist die häufigste Form der Demenz und betrifft weltweit mehrere Millionen Menschen. Wie die Krankheit entsteht, ist bislang nicht vollständig geklärt. Neueste...

Thanks to @afi-ev.bsky.social for funding our project @helmholtzmunich.bsky.social ! Excited to delve into new aspects of Alzheimers research!

www.alzheimer-forschung.de/forschung/fo...

Induced ubiquitination bypasses canonical ERAD to drive ER protein degradation Heterobifunctional proteolysis-targeting chimeras (PROTACs) have emerged as a powerful strategy to degrade disease-relevant proteins, enabling targeting of previously "undruggable" proteins. Current d...

New preprint out! We show that PROTAC-induced ubiquitination can bypass canonical ERAD to degrade ER membrane proteins. Wonderful collaboration w/ @dannomura.bsky.social and huge credit to grad student superstar Sydney Tomlinson!
www.biorxiv.org/content/10.1...

Fantastic. Congrats 🤩!

FSP1-mediated lipid droplet quality control prevents neutral lipid peroxidation and ferroptosis - Nature Cell Biology Lange et al. identify a lipid droplet quality control pathway in which FSP1 safeguards stored neutral lipids from lipid peroxidation, thereby preventing the induction of ferroptosis.

Excited to share our study out in @natcellbio.nature.com! Led by @mikelangelipid.bsky.social, we identify the first #LipidDroplet lipid quality control pathway: LD-localized FSP1 protects stored lipids from oxidative damage and prevents LD-initiated #ferroptosis.
www.nature.com/articles/s41...

I was honored to give the L. Carroll King Memorial Lectures at Northwestern University, sponsored by the Chemistry Department.

Professor King was a pioneering researcher and #teacher who joined Northwestern’s faculty in 1942. He was active in advancing ideas about chemical #education

😂

I’m excited to lead this new journal that will focus on how cells interact with their environment. We are assembling a top tier editorial board, key partnerships, and looking to be the primary forum for the rapidly growing field of spatial biology.

Check out our new paper 🎉. Thanks to everyone who was involved 🙏🏻.

ASBMB names 2026 award winners Check out their lectures at the annual meeting in March in the Washington, D.C., metro area.

Humbled and honored to receive the 2026 Avanti Award in Lipids from ASBMB! Grateful to my exceptional lab, mentors, and collaborators for their support and inspiration. Excited to keep pushing the boundaries of lipid biology and therapeutics!
www.asbmb.org/asbmb-today/...

Tenure track position alert! Assistant Professor of Molecular Therapeutics in MCB @UCBerkeley. Apply and come be our colleague! 🎉
aprecruit.berkeley.edu/JPF05098

Hot off the presses! Was an honor to team up with Scott Dixon @stanforduniversity.bsky.social on this Nature Cancer review. We reflect on hurdles that have slowed translation of ferroptosis-directed therapies and share ideas on what it will take to bring these therapies to the clinic. rdcu.be/eBbqV

Multiple oestradiol functions inhibit ferroptosis and acute kidney injury - Nature 17β-oestradiol establishes an anti-ferroptotic state in female kidney tubules.

Happy to start at Bluesky with a post on our recent manuscript at @nature.com:

www.nature.com/articles/s41...

Great collaboration with cool scientists such as @theprattgroup.bsky.social, @fedorovalab.bsky.social and many who do not (yet) have a Bluesky account.

Congrats James! 🎉🥂

📢 Our August issue is online!

🎨 The cover highlights a Feature Review from Stephanie Rosswag de Souza, @gzaffagnini.bsky.social, and @bokelab.bsky.social on how proteostasis functions in cellular dormancy across a number of examples, from yeast to adult quiescent stem cells and vertebrate oocytes.

Don't miss out on other great Review content!
📝 A Review from @angelifriedmann.bsky.social, @k-hadian.bsky.social, et al details the metabolic code of ferroptosis
📝 @damelab.bsky.social et al describe how prokaryotes and viruses possess histone-mediated chromatin organization

(1/n)

Riboflavin metabolism shapes FSP1-driven ferroptosis resistance Membrane protection against oxidative insults is achieved by the concerted action of glutathione peroxidase 4 (GPX4) and endogenous lipophilic antioxidants such as ubiquinone and vitamin E. Deficienci...

🚨Preprint alert 🚨

We identify riboflavin (vitamin B₂) as a key modulator of ferroptosis sensitivity via stabilizing FSP1 & recycling lipid-soluble antioxidants.

www.biorxiv.org/content/10.1....

pls check @olzmannlab.bsky.social

www.biorxiv.org/content/10.1...

#ferroptosis #FSP1 #antioxidants

Fantastic lab with exciting science!
Strong recommendation.
Apply 👇🏻

A new postdoc position in our group will open early next year — looking for candidates with a proven track record & relevant experience.

If #CRISPRscreens, #syntheticlethality, #smallmolecules & #celldeath excite you, let’s talk! DMs welcome.

pls share 🙏

Thanks to James Olzmann and Scott Dixon for organizing a fantastic #faseb #ferroptosis meeting in Scottsdale AZ! Lots of great science as ferroptosis continues to impact diverse biology and diseases. Can’t wait for the next one! @olzmannlab.bsky.social

Fellowships Job: Postdoctoral Research Fellow - Jones Lab Chemistry at Dana-Farber Cancer Institute in 450 Brookline Ave, Boston, MA Postdoctoral Research Fellow - Jones Lab Chemistry job

We're hiring postdoctorate fellows in covalent chemical biology - pass the word. careers.dana-farber.org/job/11940/po...
careers.dana-farber.org/job/11941/po...

Online now - the Review "The metabolic code of #ferroptosis: nutritional regulators of cell death" from @angelifriedmann.bsky.social @k-hadian.bsky.social and colleagues.

#LipidPeroxidation #Nutrients #Metabolites #Vitamins #Lipids

Read it here 👉 authors.elsevier.com/sd/article/S...

The metabolic code of ferroptosis: nutritional regulators of cell death Ferroptosis is a distinctive form of regulated cell death driven by iron-dependent phospholipid peroxidation. Its initiation and suppression are finel…

New review together with
@k-hadian.bsky.social group-

Have fun reading!
#ferroptosis #nutrition #celldeath

www.sciencedirect.com/science/arti...

Porträtfoto von Virologin Dr. Michelle Vincendeau vom Helmholtz Munich

Virologin Michelle Vincendeau @m-vincendeau.bsky.social hat uns ein paar Fragen zu ihrer Forschung mit #Organoiden beantwortet und beschreibt, wie sie damit den Einfluss bestimmter Viren auf die Gehirnentwicklung untersucht. 🧠
#HERVs @www.helmholtz-munich.de
👉 www.infectnet.org/web/blog-pos...

Helmholtz Munich Helmholtz Munich, is a member of the Helmholtz Association of German Research Centres

👩‍🔬 Die Münchner Virologin Dr. Michelle Vincendeau @m-vincendeau.bsky.social erforscht mit Gehirn-Organoiden die Rolle von Humanen Endogenen Retroviren ( #HERVs ) bei der Gehirnentwicklung und der Entstehung von neurodegenerativen Erkrankungen. 🧠
👉 www.helmholtz-munich.de/en/viro/rese...

ÖAW: Georg Winter Life Science Direktor des AITHYRA-Instituts Biochemiker verstärkt Akademie-Institut für KI in der Biomedizin +++ ÖAW-Präsident Faßmann: „AITHYRA schon jetzt Anziehungspunkt für exzellente Forschende“

Bei unserem neuen Life Science Institut #AITHYRA gibt es den nächsten Meilenstein: Georg Winter wird neben @mmbronstein.bsky.social Direktor. Damit ist das Führungsteam komplett. Welcome on Board, Georg! www.oeaw.ac.at/news/oeaw-ge...

So true! 😊