Discovery Continuum Seminar Drug discovery and development can sometimes feel like having a growing list of unprocessed samples with turnaround times that continue getting shorter. Join us for ...

🚨PHILADELPHIA🚨 @sciex.bsky.social is hosting a Discovery Continuum Event in King of Prussia on 4/30/26!
Registration and agenda can be found here: sciex.com/events/bioph...

Discovery Continuum Seminar Drug discovery and development can sometimes feel like having a growing list of unprocessed samples with turnaround times that continue getting shorter. Join us for ...

🚨PHILADELPHIA🚨 @sciex.bsky.social is hosting a Discovery Continuum Event in King of Prussia on 4/30/26!
Registration and agenda can be found here: sciex.com/events/bioph...

Scanning DIA on the ZenoTOF 8600 system enables ultra-sensitive and quantitative proteomics from single cells to post-translational modifications in a compact platform Mass spectrometry-based proteomics increasingly demands platforms that combine quantitative rigor with the discovery capabilities of accurate mass systems. Here we present the ZenoTOF 8600 system, a compact mass spectrometry system that integrates enhanced ion capture and transmission optics with an optical detection system, Zeno trap-enhanced MS/MS, electron-activated dissociation, and scanning quadrupole data-independent acquisition (ZT Scan DIA). We show that ZT Scan DIA outperforms conventional variable-window DIA (Zeno SWATH DIA) in both identifications and quantitative reproducibility, and demonstrate the platform’s versatility across proteomics applications: thousands of protein groups from bulk samples at up to 500 samples per day, single-cell proteomics yielding up to 4,700 proteins, accurate ratio recovery in mixed-species quantitative benchmarks, low-attomole targeted quantitation, and detection of disease-relevant phosphorylation in a Parkinson’s disease cellular model using complementary CID and EAD fragmentation. The instrument’s compact footprint makes it attractive for settings where both analytical breadth and operational robustness are required.

Why choose between sensitivity and discovery?

ZenoTOF 8600 system = triple quad–class sensitivity + accurate mass QTOF.

One platform. No compromises. 🔥

Learn more: buff.ly/tvralVM

#proteomics #QTOF

The rise of GLP-1 therapeutics is pushing peptide bioanalysis to new limits.

Experts Todd Stawicki and Shane Needham (SCIEX), discuss how high-resolution MS is helping labs deliver greater sensitivity, selectivity, and speed.

🔗 https://ow.ly/ELi350Yqcz9

#MassSpectrometry #GLP1 #Bioanalysis

Higher throughput and coverage than O-Link or Illumina Protein Prep - on a SCIEX? Yikes. Okay, so if there is legitimate instrument competition across the board, I think there should be some seriously competitive pricing...

Hot dog- here comes Sciex with a statement study - proteomicsnews.blogspot.com/2026/03/high...

Join IonOpticks and Dr Tim Heymann (@mannlab.bsky.social Max Planck Institute) for our webinar on March 27, combining advanced MS with optimised separations. Learn how workflows on Orbitrap Astral and ZenoTOF 8600 enable reproducible, high-performance proteomics. Registration opens Friday March 13.

Scanning DIA on the ZenoTOF 8600 system enables ultra-sensitive and quantitative proteomics from single cells to post-translational modifications in a compact platform Mass spectrometry-based proteomics increasingly demands platforms that combine quantitative rigor with the discovery capabilities of accurate mass systems. Here we present the ZenoTOF 8600 system, a compact mass spectrometry system that integrates enhanced ion capture and transmission optics with an optical detection system, Zeno trap-enhanced MS/MS, electron-activated dissociation, and scanning quadrupole data-independent acquisition (ZT Scan DIA). We show that ZT Scan DIA outperforms conventional variable-window DIA (Zeno SWATH DIA) in both identifications and quantitative reproducibility, and demonstrate the platform's versatility across proteomics applications: thousands of protein groups from bulk samples at up to 500 samples per day, single-cell proteomics yielding up to 4,700 proteins, accurate ratio recovery in mixed-species quantitative benchmarks, low-attomole targeted quantitation, and detection of disease-relevant phosphorylation in a Parkinson's disease cellular model using complementary CID and EAD fragmentation. The instrument's compact footprint makes it attractive for settings where both analytical breadth and operational robustness are required.

(BioRxiv All) Scanning DIA on the ZenoTOF 8600 system enables ultra-sensitive and quantitative proteomics from single cells to post-translational modifications in a compact platform: Mass spectrometry-based proteomics increasingly demands platforms that combine quantitative… #BioRxiv #MassSpecRSS

Characterizing the ZenoTOF 8600 in collaboration
@sciex.bsky.social . Scanning DIA on a compact platform — ~10K protein groups in bulk to single-cell proteomics & Parkinson's-relevant phosphosite detection with complementary CID & EAD fragmentation.
biorxiv.org/content/10.64898/2026.03.12.711261v1

Spectral Quality-Guided Optimization of Hybrid EAciD Fragmentation on the ZenoTOF 7600 System Enables Efficient Characterization of the Serum N-Glycoproteome The analysis of N-glycopeptides using mass spectrometry comes with numerous challenges, one of which is the unique fragmentation features associated with glycopeptides. Generally, low energy collision...

Spectral Quality-Guided Optimization of Hybrid EAciD Fragmentation on the ZenoTOF 7600 System Enables Efficient Characterization of the Serum N-Glycoproteome #AC pubs.acs.org/doi/10.1021/...

News in Proteomics Research blog post | EAciD optimization for glycopeptides on a ZenoTOF! proteomicsnews.blogs...

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#proteomics #prot-other

UHPLC–MS/MS Quantification of Human Cytosolic Aldehyde Oxidase: Heat‐Assisted In‐Solution Protein Denaturation and Digestion Rationale The quality of protein denaturation and digestion is critical in determining the performance of a UHPLC–MS/MS method in absolute protein quantification. Previous UHPLC–MS/MS methods on hum...

UHPLC–MS/MS Quantification of Human Cytosolic Aldehyde Oxidase: Heat‐Assisted In‐Solution Protein Denaturation and Digestion #RCM analyticalsciencejournals.onlinelibrary.wiley.com/doi/10.1002/...

Development of a MS binding assay to analyze the interactions of drugs with the ifenprodil binding site of NMDA receptors with GluN2B subunit Negative allosteric modulators interacting with the ifenprodil binding site of NMDA receptors with GluN2B subunit are of particular interest for the t…

Development of a MS binding assay to analyze the interactions of drugs with the ifenprodil binding site of NMDA receptors with GluN2B subunit #JPBA www.sciencedirect.com/science/arti...

Non-targeted screening of per- and polyfluoroalkyl substances: Advanced methods, challenges, and environmental health Per- and polyfluoroalkyl substances (PFAS), a class of synthetic fluorine-containing organic compounds, pose a serious threat to the ecological enviro…

Non-targeted screening of per- and polyfluoroalkyl substances: Advanced methods, challenges, and environmental health #EcoEnvironHealth www.sciencedirect.com/science/arti...

Register: sciex.li/xoemx7

The Delaware Valley Mass Spec Discussion Group is BACK!!
Join us at Villanova University on 3/17 for networking and a presentation by John Kellie with AstraZeneca.
#MassSpectrometry #Philadelphia #ACS

SCIEX is proud to be a part of US HUPO and help drive inspiration and innovation in proteomics! Join us at booth 19, catch the latest proteomics research at Monday’s lunch seminar, and visit our posters to learn more about the ZenoTOF 8600 system.

#USHUPO #USHUPO2026

Sialic Acid Linkage Identification in Glycosylated Peptides Using Multitandem Collision-Induced and Electronically Excited Dissociation Mass Spectrometry In our previous publication [Anal. Chem. 2023, 95, 7458–7467], we demonstrated the use of electron capture dissociation for Sa linkage analysis in N-glycans; however, its application was challenging b...

Incredible work just published yesterday using the ZenoTOF 7600
@sciex.bsky.social #Glycosylation #PTMs
pubs.acs.org/doi/10.1021/...

Sialic Acid Linkage Identification in Glycosylated Peptides Using Multitandem Collision-Induced and Electronically Excited Dissociation Mass Spectrometry pubs.acs.org/doi/10....

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#proteomics #prot-paper

Sialic Acid Linkage Identification in Glycosylated Peptides Using Multitandem Collision-Induced and Electronically Excited Dissociation Mass Spectrometry In our previous publication [Anal. Chem. 2023, 95, 7458–7467], we demonstrated the use of electron capture dissociation for Sa linkage analysis in N-glycans; however, its application was challenging because its diagnostic capabilities depended on the size of the glycans and peptide backbones. In this work, we propose a universal method for analyzing Sa linkages in N-glycans and O-glycans that is applicable to both glycopeptides and free glycans. Specifically, electronically excited dissociation (EED) is applied to the antennary SaGalHexNAc fragments that collision-induced dissociation (CID) produces from glycopeptides and glycoproteins. We found that EED on the fragments produced the Z2• fragment when Sa was linked in α(2,3) in N-glycans, but it was negligibly weak in the cases with α(2,6) linkages. This method was expanded to O-glycans, though the discrimination between the two Sa linkages was not as prominent as that of N-glycans. We introduced four synthesized authentic glycan standards: SaGalHexNAc-OH in the free glycan forms in two Sa-Gal linkages and HexNAc: GlcNAc and GalNAc established the calibration of the Sa-linkage diagnostics in both sialylated N- and O-glycans. We confirmed that the water-lost products by CID from the free form standards have the same structures as the CID products from the native glycans and glycopeptides, which is followed by EED. The established methods were successfully applied to native glycopeptides and glycoproteins, including egg yolk glycopeptide, bovine fetuin, and human erythropoietin.

Sialic Acid Linkage Identification in Glycosylated Peptides Using Multitandem Collision-Induced and Electronically Excited Dissociation Mass Spectrometry #JASMS pubs.acs.org/doi/10.1021/...

#glycotime

There's still time to register ahead of Thursday's happy hour! #Philadelphia #Academic #Research #MassSpec sciex.com/Hidden/amer-...

Researcher Recess

🚨Philadelphia Researchers🚨
@sciex.bsky.social is hosting a Researcher Recess on 2/19 at White Dog Cafe in University City including:
-Delicious food & refreshing drinks
-Fun games and networking
-A chance to win exciting prizes

Save your spot here: sciex.com/Hidden/amer-...
#MassSpectrometry

LFQ Benchmark Dataset - Generation Beta: Assessing Modern Proteomics Instruments and Acquisition Workflows with High-Throughput LC Gradients www.biorxiv.org/cont...

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#proteomics #prot-preprint

Pushing proteomics forward: Prof. Matthias Mann on SCIEX ZenoTOF 8600 system at HUPO 2025 Join Prof. Matthias Mann, Ph.D. from the Max Planck Institute as he shares his first-hand experience with the SCIEX ZenoTOF 8600 system—a next-generation, high-sensitivity, compact, and quantitative…

Watch Prof. Matthias Mann from the Max Planck Institute discuss the ZenoTOF 8600 at #HUPO2025. His presentation covers the transformative impact of this technology on protein analysis, focusing on enhanced sensitivity, quantitation, and real-world applications!

𝗪𝗵𝘆 𝗻𝗼𝘁 𝗷𝗼𝗶𝗻 𝗮 𝗻𝗲𝘄 𝗰𝗼𝗺𝗺𝘂𝗻𝗶𝘁𝘆 𝘁𝗵𝗶𝘀 𝘆𝗲𝗮𝗿❓ Check out the #BioACollective: Your Mass Spec Bioanalysis Community on #LinkedIn 👉 bit.ly/4kML0TU

#BioACommunity #Bioanalysis #MassSpectrometry #Biopharma #Pharma #SCIEX #MeetTheBioACommunity

Researcher Recess

🚨Philadelphia Researchers🚨
@sciex.bsky.social is hosting a Researcher Recess on 2/19 at White Dog Cafe in University City including:
-Delicious food & refreshing drinks
-Fun games and networking
-A chance to win exciting prizes

Save your spot here: sciex.com/Hidden/amer-...
#MassSpectrometry

𝗡𝗲𝘄 𝘆𝗲𝗮𝗿, 𝗻𝗲𝘄 𝗵𝗮𝗯𝗶𝘁𝘀? Join the #BioACollective: Your Mass Spec Bioanalysis Community to share ideas and meet like-minded people.

Join us on #LinkedIn today 👉 bit.ly/4kML0TU

#BioACommunity #Bioanalysis #MassSpectrometry #Biopharma #Pharma #SCIEX #MeetTheBioACommunity

Veloxity Labs Acquires SCIEX Accurate Mass Spectrometer, the ZenoTOF 8600 System, to Accelerate Peptide and Complex Bioanalysis The first bioanalytical CRO in the United States to bring the ZenoTOF 8600 system online; expands capacity and adds selectivity/sensitivity headroom for GLP-1 receptor agonists and broader peptide…

#DidYouHear? US-based CRO Veloxity Labs continues to expand its bioanalytical capabilities with the ZenoTOF 8600 system 👀

This marks a meaningful step forward in complex bioanalysis.

🔗 www.biospace.com/press-releas...

#MassSpec #Bioanalysis #Peptides #Proteomics #SCIEX #ZenoTOF8600

Multistage Tandem Mass Spectrometry Using an Electron-Activated Dissociation Device with a Linear Ion Trap and Structural Identification of Cardiolipins We have developed an electron-activated dissociation (EAD) device with product isolation functionality for multistage tandem mass spectrometry (MSn). The EAD portion is a branched magneto-radio freque...

pubs.acs.org/doi/10.1021/...

Beyond the Usual PFAS Suspects Mass spectrometry-driven non-targeted screening is revealing previously undetected PFAS in food, water, and the environment

Craig Butt from SCIEX explains how SWATH DIA mass spec is helping uncover the unknowns.
🔗 Read more: theanalyticalscientist.com/issues/2025/...
#PFAS #MassSpec #SCIEX #ScienceForGood #DanaherNews