For #FluorescenceFriday
Bicolored sebaceous glands, showing differential lectin reactivity, in the foxn1-null (nu/nu) skin.
#epidermis
#glycosylation
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Hashtag
#Glycosylation
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My lab in Kiel, Germany, studies the regulation of #glycosylation in the #Golgi apparatus and we are still looking for a motivated PhD student. Please spread the word/get in touch! #glycotime #SPPL3
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#MendelianRandomization #ImmunoglobulinG #BladderCancer #ProstateCancer #UrologicalNeoplasms #KidneyCancer #Glycosylation
www.archivesofmedicalscience.com/Exploring-th...
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Incredible work just published yesterday using the ZenoTOF 7600
@sciex.bsky.social #Glycosylation #PTMs
pubs.acs.org/doi/10.1021/...
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🚨One week left to register for our next GTA webinar with Dr. Mousseau!
Register now: canadianglycomics.ca/training/web...
#Glycotime #Glycomics #Glycoscience #AlzheimersDisease #Glycosylation
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⏰ Reminder: Join the GTA-organized #webinar with Dr. Darrell Mousseau (usask ) on how patient-derived brain organoids are being used to study #Alzheimers disease and ALS, including #glycosylation changes linked to microglial function.
Register: canadianglycomics.ca/training/web...
#Glycotime
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#Glycans probably have more "copies/cell" than #proteins and changes in #glycosylation could potentially be remarkable biomarkers for diseases as well as targets for therapeutics. This post explores the abundance of glycans on the cell surface and it is worth a read to recognize these #biomolecules.
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Ten more days to apply! We are still looking forward to applications from students eager to study #SPPL3 and other proteases and their role in the regulation of #Golgi #glycosylation. #glycotime
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Have you heard of sugar alcohols / artificial sweeteners, such as erythritol, sorbitol, mannitol and xylitol? Learn more about these interesting small sugars and where they are found in our latest blog post, research.bidmc.org/ncfg/blog/23...
#glycotime #glycosylation #science #artificialsweeteners
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📰 New & Featured | #Glycosylation site-specific ADCs (#gsADCs) harness the #Asn297 N-glycosylation site on the #IgG Fc for precise drug loading.
⚙️Workflow: glycosidase trim (e.g. endo S2) ➜ azide install via #GalT(#Y289L) ➜ cyclooctyne click → stable, uniform #ADCs.
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Our proteomics experts Sibylle Pfammatter and Christian Panse attended HUPO 2025 in Toronto, presenting 3 posters on #glycosylation, #phosphorylation & integrative #PTM analysis. Great reconnecting with the community! #HUPO2025
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Iron-catalyzed & 1,2-cis selective #glycosylation for aminoglycoside synthesis⚡ Broad scope, reiterative use & scalable to multigrams! Mechanistic insights reveal a unique atom-transfer strategy in our #Synpacts by Hao Xu & co-workers
#iron #catalysis
👉 buff.ly/woziH9i
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Spotlight @jcb.org: Anant Menon @weillcornell.bsky.social discusses recent advances by Li, Suzuki et al. (rupress.org/jcb/article/...), identifying a DLO-pyrophosphatase (Llp1), which maintains DLO quality control in eukaryotes. rupress.org/jcb/article/...
#lipid #Organelles #Glycosylation
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Spotlight: Anant Menon @weillcornell.bsky.social discusses recent advances by Li, Suzuki et al. (rupress.org/jcb/article/...), identifying a DLO-pyrophosphatase (Llp1), which maintains DLO quality control in eukaryotes. rupress.org/jcb/article/...
#Biochemistry #lipid #Organelles #Glycosylation
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Most people think that #glycosylation is only extracellular. But there is increasing evidence for the existence of intracellular proteins also being glycosylated. Check out this blog post to learn more about this topic!
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🤯 Did you know proteins inside cells can be glycosylated?! 🔬 Our latest blog post dives into the surprising world of intra-cellular protein glycosylation & its vital role in biology!
👉 research.bidmc.org/ncfg/blog/21...
#glycans #glycosylation #posttranslationalmodification #glycotime
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Stress Alters Brain Sugar Molecules, Triggering Depression
Chronic stress reduces sialylation and the enzyme St3gal1 in the mouse prefrontal cortex, leading to depressive-like behavior; restoring St3gal1 reverses the symptoms. Read more: getnews.me/stress-alters-brain-suga... #glycosylation #depression
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Dolichol-linked oligosaccharide (DLO) is the precursor for asparagine-linked protein #glycosylation. In @jcb.org, Sheng-Tao Li, Tadashi Suzuki et al. identify a DLO-pyrophosphatase (Llp1), which is involved in DLO homeostasis/quality control. rupress.org/jcb/article/...
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Dolichol-linked oligosaccharide (DLO) is the precursor for asparagine-linked protein #glycosylation. Sheng-Tao Li, Tadashi Suzuki et al. identify a DLO-pyrophosphatase (Llp1), which is involved in DLO homeostasis/quality control. rupress.org/jcb/article/...
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Excited to share our new ChemPhysChem paper 🎉
🔗 doi.org/10.1002/cphc...
MD simulations reveal how glycan fluctuations impact water networks & proton shuttle dynamics in this cancer-linked enzyme.
#CompChem #MolecularDynamics #EnzymeCatalysis #Glycosylation
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Meet the BioF:GREAT Team at The Society for Glycobiology's Annual Meeting in San Diego this November and be part of the future of glycoscience! Register for SfGlycobiology here:
www.glycobiology.org/annual-meeting
See you there!
#SfGlycobiology #glycotime #biotech #glycotime #glycosylation
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📚 A Review for your weekend reading!
🦠 Protein O-glycosylation in the Bacteroidota phylum
👉 buff.ly/HO2RBlj
🖊️ @mateuslab.com @andrenmateus.bsky.social
#Glycosylation #Microbiome
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Published in Precision Clinical Medicine, a review integrates molecular biology, glycoproteomics, and clinical evidence to show how changes in glycosylation drive immunological, metabolic, and oncogenic pathways in the kidney.
#Glycosylation
Details: doi.org/10.1093/pcmedi/pbaf017
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Congratulations to Professor Jiaoyang Jiang on receiving a prestigious Vilas Faculty Mid-Career Investigator Award! Her groundbreaking work on protein #glycosylation & enzymes OGT & OGA is opening doors to future treatments for #cancer, Alzheimer’s & more. pharmacy.wisc.edu/2025/06/08/s...
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Meet SHIELD! ✋
Today: The Synthetic Organic Chemistry Group at Radboud University is developing new chemical biology approaches to study glycosylation in context of viral infections.
www.ru.nl/en/departmen...
#Glycosylation #ViralInfections #SHIELDproject #SyntheticChemistry #RadboudUniversity
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New #glycosylation strategy alert! Wang, Guo & Shu's #titanium-catalyzed radical method allows selective late-stage #glycosylation of bioactive molecules 🧪 – a powerful tool for #medicinalchemistry and drug development!
👉 buff.ly/3d5JzcX
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Proud of Kaisa Pakari @kpakari.bsky.social to receive the 2025 Schmeil young researcher award for her #PhD thesis. She established 🐟 models to address disorders of #glycosylation #CDG by advancing #baseediting range for precise genome editing @wittbrodtlab.bsky.social @cos.uni-heidelberg.de
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#Medsky🧪 #IDsky #immunosky #publichealth in this small study , the findings point to a 🔑 shift in IgG #glycosylation of #COVID patients & vaccinated individuals over time that can predict disease severity & 💉 responsiveness,
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GDP-fucose transporter SLC35C1: a potential regulatory role in cytosolic GDP-fucose and fucosylated glycan synthesis
➡️ buff.ly/0h7HMY7
#Fucose #Glycans #Glycosylation
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Developing #glycoproteomics reveals the role of posttranslational #glycosylation in the physiological and pathological processes of male reproduction #iMetaOmics onlinelibrary.wiley.com/doi/10.1002/...
#biotech
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