🧬 ¿Y si el origen de una complicación grave del embarazo estuviera en los primeros pasos de la placenta?
Un estudio del grupo de Vicente Pérez García en el CBM revela un mecanismo genético temprano que podría explicar la preeclampsia precoz.
www.cbm.uam.es/index.php/20...
Manos formando un corazón sobre el vientre de una embarazada.
🤰Un mecanismo genético temprano en la formación de la placenta explicaría una grave complicación del embarazo
🧬Liderado por el @cbm-csic-uam.bsky.social el trabajo identifica que el desajuste de un gen regulador origina alteraciones como la preeclampsia
➡️http://tiny.cc/yxg1101
#BAP1 overexpression induces early onset #preeclampsia–like features in #placental #organoids: ❌blocked extravillous #trophoblast differentiation
❌impaired syncytialization
🔥persistent pro-inflammatory signatures @cbm-csic-uam.bsky.social @csic.es 👏🥳team! www.nature.com/articles/s41...
🚨🚀 New bioRxiv preprint! 🧫 We developed hormonally responsive bovine oviductal organoids producing bioactive fluid 🧬 that enhances sperm capacitation & acrosome reaction 🐄🐄✨🥌🥌
@cbm-csic-uam.bsky.social @cipfvalencia.bsky.social @um.es
Is the placenta in crisis? See our paper in Biological Reviews:
“Placental crises: disruptive selection and maternal under-investment as the foundations of mammalian placental evolution and dysfunction”
Open access doi.org/10.1002/brv.....
Huge credit to @davislaundon.bsky.social who led this work.
Exciting News!
🚀 Registration Open! | Loke CTR Annual Meeting 2026 🎉
📅 16-17 July 2026
📍 St John’s College, Cambridge | 💻 Hybrid conference (in-person & online)
🔬 Epigenetics of embryogenesis and placentation
📌 To find out more and to register
www.trophoblast.cam.ac.uk/ctrconferenc...
A human embryo implantation model from the @Rugg-Gunn Lab
*key for understanding the early extraembryonic-maternal interactions
Congrats to everyone involved! It’s been great to see this project develop. Huge credit to the @babrahaminst.bsky.social authors 🥂🍾
www.cell.com/cell/fulltex...
Very excited to finally share this work! 🥳🎊🎉Huge thanks to my former colleagues, the collaborators and @grazianomartello.bsky.social. See the post below for more info:
En estos días celebramos las 40 Jornadas Científicas del CBM. Renovadas en el año de nuestro cincuentenario, 50 de nuestros IPs presentarán su investigación en charlas y pósters a lo largo de dos días. Estupenda oportunidad de interacción multidisciplinar. www.cbm.uam.es/index.php/ev...
Top: lf5 mutant cells untransformed, or expressing CDKL5-GFP, CDKL5K33R-GFP, CDKL5S162A,T164A,Y166A-GFP, or CDKL5Y166F-GFP, and lf2 mutant cells expressing CDKL5-GFP were stained for flagella (acetylated tubulin, red) and CDKL5 (GFP, green top panels, gray in bottom panels). The cell bodies of all strains are green (or gray) due to autofluorescence. Wild-type CDKL5-GFP concentrates at the basal end of the flagellar shaft (arrows). Note that all of the mutant CDKL5 proteins lack the major enrichment at the basal end of the flagellum but continue to show punctate stain along the flagellar shaft. Scale bar, 5 µm. Z projection of slices taken at 0.5-µm intervals. Bottom: Larger version of the first image in the top row.
CDKL5 Deficiency Disorder (CDD) leads to seizures & intellectual disability. This study shows that #Chlamydomonas CDKL5 kinase is activated by the LF2/CDK20 kinase; CDKL5 in turn regulates #intraflagellar transport via protein abundance & phosphorylation #cilia @plosbiology.org 🧪 plos.io/45490eP
Earlybird deadline extended 🚨Join us at the Frontiers in Stem Cell Innovation (FISCI) Conference on the 5th –6th February 2026 in Cambridge.
Up to 50% off ends 16th January: www.eventbrite.co.uk/e/frontiers-...
🚨Preprint! #Placental #organoids developing #preeclampsia (PE)?🤯Boosting #BAP1 induced key traits of early-onset PE:
❌impaired syncytialization & EVT differentiation
🔥persistent pro-inflammatory signals
🤒broad placental dysfunction
🚀🥦🎉team!
@cbm-csic-uam.bsky.social
www.biorxiv.org/content/10.1...
🚨 New preprint!
We built a single-cell atlas of 14 multilayered epithelia and revealed a conserved transcriptomic program guiding tissue architecture and fate composition. Our work brings decades of tissue-specific studies together into a unified evo-devo framework.
www.biorxiv.org/content/10.1...
· #AcademicSky ·
The European Research Council is launching €7m Plus Grants for ambitious, long‑term research — open to researchers at any career stage but limited to about 30 awards; current ERC grantees and applicants are ineligible, reports @clanicholson.bsky.social.
🧬 PhD Position: Evolutionary & Comparative Genomics 🕷️
Join us at @uni-goettingen.de for a 3-year PhD (65% TV-L E13).
We will investigate the genomic & phenotypic impact of gene duplication across 233 arthropod genomes!
More infos 👇 and s.gwdg.de/eDrAAY
#Evolution #Genomics #Bioinformatics
Beta-Blockers after Myocardial Infarction with Normal Ejection Fraction | New England Journal of Medicine www.nejm.org/doi/full/10....
Looking to pursue cutting-edge research in early development, maternal-fetal interaction, or placental biology? See 👇
- Funded PhD www.trophoblast.cam.ac.uk/phd-students...
- Next Generation Fellowship www.trophoblast.cam.ac.uk/next-generat...
- MPhil www.mphil.bio.cam.ac.uk/mphil-pathwa...
2 weeks left to apply! Fully-funded 4-year PhD studentships for home or overseas students, applications open till 4 November. 🔗 Please like and share to spread the word! www.trophoblast.cam.ac.uk/phd-students...
Take a look at projects for 2025/26 www.trophoblast.cam.ac.uk/opportunitie...
Very happy to share I've written a review on placental vascular formation in mice and humans, now published in @dev-journal.bsky.social.
journals.biologists.com/dev/article/...
@idrm.ox.ac.uk Funded by the @thebhf.bsky.social
✳️ Join us for this week's interesting #CiMUSSeminar with guest speaker @vpglab.bsky.social from @cbm-csic-uam.bsky.social.
Dr. Vicente Pérez explores novel therapies for pregnancy disorders & cancer
Hosted by PI @mobilegenomes.bsky.social mes.bsky.social
#RedeCIGUS #FondosEuropeos @usc.gal
orange and cyan microscopy image of cartilage tissues
Using #CRISPR/Cas9 to genetically modify cells to produce extracellular matrices with altered compositions.
elifesciences.org/reviewed-pre...
Check out these feather buds on the chicken embryo's wing! Our latest study @plosbiology.org reveals that temporary inhibition of sonic hedgehog signalling transforms feathers into simple, protofeather-like structures—similar to those of their dinosaur ancestors🔬🦖🧪
journals.plos.org/plosbiology/...
A study in Nature Communications shows that Zika virus NS1 induces tunneling nanotubes in placental cells, which facilitate viral spread and transport of mitochondria in placental cells. The findings could be used to develop therapeutic strategies targeted against this transmission mode. 🧪
Our new paper linking Tregs, uNK cells & uterine vasculature “Treg cells promote decidual vascular remodeling and modulate uterine NK cells in pregnant mice” super effort from Alison Care, Shanna Hosking, Lachlan Moldenhauer and all the team! insight.jci.org/articles/vie...
Applications are open for our Caregiver Travel Grant 2025! Apply now for a chance to receive flexible funding to cover caregiving expenses while attending an in-person scientific conference! Apply: www.mothersinscience.com/caregiver-tr... 📅 Deadline: March 31, 2025 #WomenInSTEM #STEMM #AcademicMama
Excited to share our most recent work in Cell Stem Cell, led by @georgiaplea.bsky.social, characterising determinants of DNA methylation patterning in human trophoblast stem cells! A great collaboration with @vpglab.bsky.social.
tinyurl.com/93mchcd2
@loke-ctr.bsky.social @cam-repro.bsky.social
