We would like to bring our EVOLVE consortium with its PhD positions to your attention again! Sharing is also much appreciated.

Currently, there's a lot of interest in quantitative models that would help us understand and predict features of the complex cellular systems that underlie human health and disease - think about virtual cells, for example. On can trace some of these ideas back to the early days of systems biology.

Kickking off the second day our @bcbhubcsic.bsky.social meeting with scientific sesions with Victor Sánchez Gaya, presenting POSTRE, a tool to predict the funcional impact of pstructural variants @hitseq.bsky.social @ibv-csic.bsky.social @csic-vaact.bsky.social

Next, Ana Martinez and Carmen Gil from @cib-csic.bsky.social presenting how to use a consortium
of AI tools for drug design, with múltiple applicatons in the clínic @bcbhubcsic.bsky.social @csic-vaact.bsky.social #2AsambleaBCBHub

Please repost: Postdoc position in antibiotic discovery in a large multidisciplinary project combining high-throughput approaches, microscopy, AI, and hit-to-lead optimization at @umontreal.ca and @mila-quebec.bsky.social. Apply to ML.Antibiotics@gmail.com. See
lnkd.in/dVVk4N3s. #microsky

🚨 The latest study from #NatureCommunications, led by Pasquale Piccolo, systematically evaluated AAV-mediated liver transduction across different fibrosis models.

Hello Nextflow: Intro and setup Enjoy the videos and music you love, upload original content, and share it all with friends, family, and the world on YouTube.

The #Nextflow #Training week has begun! 🎉

New to Nextflow or need a guided intro? Watch the brand new on-demand walkthrough videos for the "Hello Nextflow" course, and learn at your own pace!

hubs.la/Q03b2-Rk0

Quantifying Metagenomic Strain Associations from Microbiomes with Anpan www.biorxiv.org/content/10.1... 🧬🖥️🧪 #Rstats 📦 github.com/biobakery/an...

Common gynaecological disorders linked to raised heart and cerebrovascular disease risk

"They include polycystic ovary syndrome, endometriosis, heavy or irregular periods"

heart.bmj.com/content/earl...

PLOS statement on recent US Executive Orders and scientific integrity - The Official PLOS Blog Since its founding over twenty five years ago PLOS has been dedicated to advancing open science, ensuring that knowledge is accessible to…

PLOS has issued a statement on recent US Executive Orders and scientific integrity.

We are determined to stand firmly behind our mission, our values and our principles, and against any attempt at censorship or undermining of the core principles of scientific inquiry.

plos.io/3D4O8cH

Is this real? I published it again on Brain @brain1878.bsky.social 😆

Truly appreciate the leadership of @rrust.bsky.social on this great project (>300 refs!)🫡👇

The blood–brain barrier: a help & a hindrance

#Aging #Stroke #Neurodegeneration

Crossing #BBB 😎

academic.oup.com/brain/advanc...

A Vaccine For Pancreatic Cancer Continues To Show Promise In a small trial, nearly half of pancreatic cancer patients who received an mRNA vaccine for the disease had no relapse three years later.

In a small trial, nearly half of pancreatic cancer patients who received an mRNA vaccine had no signs of relapse after three years.

Dr. Vinod Balachandran from @mskcancercenter.bsky.social joins us to discuss the results and what they could mean for cancer treatment.

This is figure 1, which gives an overview of Segment Anything for Microscopy.

A paper in Nature Methods presents Segment Anything for Microscopy, a tool for segmentation and tracking in multidimensional microscopy data. https://go.nature.com/3QiRonW

Our gut microbiome and its metabolites have key interactions with our immune response to cancer and success from cancer immunotherapy. Nice perspective @jclinical-invest.bsky.social www.jci.org/articles/vie...

I generally just add scientists to communicate on jobs and things relevant to them. I can add you, it just won't be very relevant.

Tissue-resident memory CD8 T cell diversity is spatiotemporally imprinted www.nature.com/articles/s4...

Top left: intestinal gross tissue was measured in the WT, Vangl2ΔM/ΔM, and MCC950 treated Vangl2ΔM/ΔM mice after DSS treatment (n = 7). Top right: HE staining was used to compare the colonic morphology between health control and IBD patients (upper panel). The expression of VANGL2 in colon of healthy control and IBD patients was detected by immunofluorescence staining (lower panel). Bottom: Schematic diagram of the action of VANGL2 in IBD.

What is the mechanistic link between the NLRP3 #inflammasome, #autophagy & inflammatory #bowel disease (IBD)? This study shows that VANGL2 reduces #IBD progression by recruiting the ubiquitin ligase MARCH8 to regulate NLRP3 activation via OPTN-mediated autophagy 🧪 @plosbiology.org plos.io/42FTqFO

Principal Investigator positions at ELLIS Institute Finland | ELLIS Institute Finland Now recruiting new PIs in artificial intelligence and machine learning

I have big news: @ellis.eu has launched its 2nd major research center, @ellisfinland.bsky.social! I have agreed to start as founding director & the first call for PI positions is open. This is a major opportunity for outstanding researchers, join us! ellisinstitute.fi/PI-recruit

📣

PhD Research Fellow in Bioinformatics and Gene Regulation (274506) | University of Oslo Job title: PhD Research Fellow in Bioinformatics and Gene Regulation (274506), Employer: University of Oslo, Deadline: Friday, February 28, 2025

🚨 PhD in Bioinformatics & Gene Regulation 🚨

Join the Bioinformatics in Life Science (BiLS) initiative through a multidisciplinary project to unravel gene regulation from DNA to proteins, co-supervised by E. Valen @jonnings.bsky.social and me!

www.jobbnorge.no/en/available...

In @science.org today, the discovery of the neuroimmune itch-scratch circuit. And why scratching can makes things worse
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...

The feasibility of patching a severely damaged heart with stem cells as a bridge to transplant, actualized in a 46-year-old woman @nature.com

www.nature.com/articles/s41...

www.nature.com/articles/d41...

Schematic of a newly identified inter-organ communication system, showing that hepatic metabolic zonation mediated by Rspo3 plays an important role in maintaining metabolism in remote organs, such as adipose tissues and skeletal muscles, as well as locally in the liver through the inter-organ coordination consisting of neuronal and non-neuronal communication. However, in the setting of obesity, the impaired Rspo3 function in the liver leads to the disturbance of this Rspo3-mediated physiological inter-organ mechanism, paradoxically resulting in progression of pathophysiological features such as glucose intolerance, insulin resistance, fatty liver, and deterioration of organ quality. BAT, brown adipose tissue; Rspo3, R-spondin3; WAT, white adipose tissue.

#Liver #metabolism is divided between pericentral & periportal zones, but what are the broader consequences of this zonation? This study shows that proper liver zonation, regulated by R-spondin3, contributes to systemic glucose metabolism & body composition 🧪 @plosbiology.org plos.io/3PR0E2a

Marigold: a machine learning-based web app for zebrafish pose tracking - BMC Bioinformatics Background High-throughput behavioral analysis is important for drug discovery, toxicological studies, and the modeling of neurological disorders such as autism and epilepsy. Zebrafish embryos and lar...

We hope other labs find it as useful as we do! Given that it's free, we also hope it can be used in teaching labs, which are often low resourced. Congratulations to all authors! #zebrafish 🧠🧪🧬 bmcbioinformatics.biomedcentral.com/articles/10....

Modern GWAS can identify 1000s of significant hits but it can be hard to turn this into biological insight. What key cellular functions link genetic variation to disease?

I'm very excited to present our new work combining associations and Perturb-seq to build interpretable causal graphs! A 🧵

We are hiring!

We have a fully-funded 2-year T32 post-doc slot to study spatial biology in lung regeneration.

Background in data visualization useful but not required.

If you’re interested or know of anyone, please get in touch or pass along!

RaredonLab.com

Description & teasers attached:

Proximal Ascending aorta is made of #SmoothMuscleCell of dual lineage origins
Luminal side: Wnt1+ #CardiacNeuralCrest
Abluminal side: Mef2c+ #SecondHeartField

Their transcript profiles by scRNAseq + snATACseq👇

#AortaEd
#ATVB 2024 @ahajournals.bsky.social
www.ahajournals.org/doi/10.1161/...

📣 We are hiring!
Join Yoshiji Lab at McGill University Dept of Human Genetics in Montreal, Canada!
yoshiji-lab.org/joinus
✅Fully Funded Positions
• 2 MSc Students
• 1 PhD Student
• 1 Postdoc
✅Goal: Using human genetics and multi-omics for drug target discovery and precision medicine

Divalent siRNA for prion disease www.biorxiv.org/content/10.1101/2024.12....

Noncanonical role of ALAS1 as a heme-independent inhibitor of small RNA–mediated silencing microRNAs (miRNAs) and small interfering RNAs (siRNAs) are 21- to 22-nucleotide RNAs that guide Argonaute-class effectors to targets for repression. In this work, we uncover 5-aminolevulinic acid synt...

In this week's @science.org from @lucksmith.bsky.social and colleagues @mskcancercenter.bsky.social | Noncanonical role of ALAS1 as a heme-independent inhibitor of small RNA–mediated silencing
#RNA #microRNA #miRNA #siRNA #argonaute🧬🧪
www.science.org/doi/10.1126/...