ENPP1 inhibitor with ultralong drug-target residence time as an innate immune checkpoint blockade cancer therapy Tumor-selective ENPP1 inhibitor is highly sought after for cancer immunotherapy to activate anti-cancer innate immunity without systemic inflammation. Wang et al. achieved this with STF-1623, which has ultralong tumor residence time but fast systemic clearance. When combined with ionizing radiation or immune checkpoint blockade, STF-1623 shows unprecedented efficacy without apparent side effects.

Online now: ENPP1 inhibitor with ultralong drug-target residence time as an innate immune checkpoint blockade cancer therapy

The source of dietary fat influences anti-tumour immunity in obese mice - Nature Metabolism This study shows that animal-based high-fat diets accelerate tumour growth and impair anti-tumour response to melanoma in obese mice, whereas plant-based high-fat diets do not.

This was a labor of love requiring lots of teamwork over years, repeating in 3 locations! Thanks to all the lab over the years, giving their time generously to this team project, & our wonderful collaborators. The source of fat matters for anti-tumor immunity 🐄🐖🧈🌴🫒🥥
www.nature.com/articles/s42...

Systemic inflammation impairs myelopoiesis and interferon type I responses in humans - Nature Immunology Stunnenberg et al. use a model of lipopolysaccharide injection in humans to characterize the transcriptomic landscape of bone marrow and blood immune cells during the hyperinflammatory and immunosuppr...

#WeekendRead! #InterferonPower! Stunnenberg Pickkers Kox, Keramati &co show @natimmunol.bsky.org that 2 LPS injections in volunteers mimic the proinflammatory & immunosuppressive phases of #sepsis & found that IFNb treatment restores immune responsiveness in the suppressive phase!

Acute exposure to high-fat diet impairs ILC3 functions and gut homeostasis Xiong et al. report that short-term, high-fat diet exposure rapidly alters the gut microbial and immune environment, disrupting tissue homeostasis. IL-22 production by group 3 innate lymphoid cells (I...

#WeekendRead! #NotAllFatIsEqual! @lexiong.bsky.social Seillet &co show @cp-immunity.bsky.social that #diet saturated fatty acids rapidly impair (while unsaturated fatty acids favor via lipid droplets) IL22 production by ILC3 supporting dysbiosis & gut permeability, exacerbating inflammation!

Eosinophil innate immune memory after bacterial skin infection promotes allergic lung inflammation Staphylococcus aureus skin infection induces eosinophil innate immune memory to exacerbate allergen-induced airway inflammation.

A new #ScienceImmunology study in mice suggests that bacterial skin infections can imprint eosinophils with innate immune memory and enhance allergic inflammation in the lungs.

Signs of life on a distant planet? Not so fast, say these astronomers Bold claims of ‘biosignature’ molecules trigger an outpouring of scepticism.

A team of scientists made headlines last night with claims that they had found the “strongest hints yet of biological activity outside the Solar System”. They have met floods of scepticism.

https://go.nature.com/3Gsyr03

Innate immune training of osteoclastogenesis promotes inflammatory bone loss in mice We previously demonstrated that long-term trained immunity (TRIM) involves adaptations that imprint innate immune memory in long-lived myelopoiesis pr…

www.sciencedirect.com/science/arti...

Regulation of osteoclast-mediated bone resorption by lipids. Fang Luo et al. Bone 9 Feb 2025 tinyurl.com/26f73sx2 …extensive fine review … lipid signaling pathways regulate osteoclast-mediated bone resorption

Multi-omics analysis of innate and adaptive responses to BCG vaccination reveals epigenetic cell states that predict trained immunity The response to vaccination and immune stimuli varies widely between individuals. To dissect population variation in immune function, Moorlag, Folkman, ter Horst, Krausgruber, et al. perform multi-omi...

Multi-omics analysis of innate and adaptive responses to BCG vaccination reveals epigenetic cell states that predict trained immunity: Immunity www.cell.com/immunity/ful...

Trained immunity in chronic inflammatory diseases and cancer - Nature Reviews Immunology Besides its beneficial effects against infection, trained immunity has recently been implicated in inflammation-related disorders and is being exploited in cancer immunotherapy. These advances may ena...

NEW Review: Trained immunity in chronic inflammatory diseases and cancer
by George Hajishengallis, Mihai Netea & Triantafyllos Chavakis
Explores the concept of 'maladaptive' TRIM - the potential to increase severity of or susceptibility to chronic inflammation and cancer.
#immunosky #immunology

First-in-class ultralong-target-residence-time p38α inhibitors as a mitosis-targeted therapy for colorectal cancer - Nature Cancer Rudalska et al. describe a novel class of p38α inhibitors with increased target residence time. They explore the drugs’ specificity, pharmacokinetics and toxicity profile and show that they are effica...

🌟Check out new online content: study from Daniel Dauch's lab:
doi.org/10.1038/s430...