Day 1 of the EMBO U-ExM Workshop at EMBL Heidelberg #EMBOExM
Great to see this workshop finally kicking off, engaged discussions, talks, and our first gelation and expansion already underway.
Many thanks to our sponsors for their support!
Looking forward to the next days !!
Ahh, this brings back great memories 🙂 Trichonympha is such a fascinating organism, its centrioles are truly stunning. Beautiful work, looking forward to reading the manuscript!
We are looking for outstanding scientists to develop ambitious research programs in molecular and cellular biology, with special interest in multidisciplinary projects and computational biology.More info: www.i2bc.paris-saclay.fr #MolecularBiology
#CellBiology #ComputationalBiology #TeamLeaders#I2BC
@cellarchlab.com The soundtrack was missing 😂
While XL/MS provided several candidates for microtubule binding proteins, the subciliary localization was further verified by @marinebrunet.bsky.social w U-ExM. This combo identified several new microtubule binding proteins including DNAJB6, which is abundant in the transition zone and axoneme
It’s done!! Molecular architecture of the ciliary base in mammalian multiciliated cells! A study 13 years in the making 👴, thanks to collab with @stearnslab.bsky.social + @centriolelab.bsky.social & visionary work by @computingcaitie.bsky.social, who integrated native #cryoET with #XLMS & #UExM 🧪🧶🧬🔬
I am excited to share our most recent work collaborating with @centriolelab.bsky.social and @stearnslab.bsky.social to look at the ciliary base of mammalian multiciliated cells w/ cryo-ET, XL/MS, and U-ExM www.biorxiv.org/content/10.6...
Just over two weeks until our 55th @bscb-official.bsky.social @gensocuk.bsky.social @ukcilianetwork.bsky.social e-symposium Tuesday April 21st 2026 15:00-17:45 BST! Join us for 6 talks from the latest rising talent!! Free & open to all.
Register: www.eventbrite.co.uk/e/bscb-genso...
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Since last year, I've been making a RELION GUI that supports viewing, navigating and running jobs in a way completely compatible with the original RELION pipeline. Now it's working nicely for both SPA and tomography! Please try it out - github.com/hanjinliu/hi...
Striking microtubule-actin compartmentalization. A cell so big must organize things I guess!
🤩
#Cilia are beautiful!
That's it, that's the tweet.
Oh, and Happy #FluorescenceFriday 🔬
Excited to share our work on the structure and function of cytoplasmic lattices within mouse embryos. A collaborative effort with @niakanlab.bsky.social and work led by @kashishsingh.bsky.social and @inaharasimov.bsky.social . It is now out on BioRxiv: www.biorxiv.org/content/10.6...
A Practical Guide to Ultrastructural Expansion Microscopy (U-ExM) in Trypanosoma brucei pubmed.ncbi.nlm.nih.gov/41627760/
An amazing example of actin imaging with our expansion microscopy probe for actin HAK-actin™.
These are U-ExM expanded platelets stained with HAK-Actin (magenta bottom), (anti-integrin αIIb magenta top), and fibrin (fibrinogen-A488, green).
Movie from preprint www.biorxiv.org/content/10.6...
🧪
Credit: Mylan Ansel
Expansion microscopy of a loricate choanoflagellate, generated by Mylan Ansel in our lab 🤩
(yes, the lorica expands. No, we don't understand how either)
Arp2/3-dependent actin assembly shapes endosomes and promotes intracellular trafficking in fission yeast
The work from Alejandro Melero @ameleroc.bsky.social and Miguel Basante-Bedoya just out in Current Biology.
www.sciencedirect.com/science/arti...
@biology-unige.bsky.social
Our paper on disease mechanisms in synucleinopathies, led by Tetiana Serdiuk, is out at Molecular Systems Biology.
#proteomics #structuralproteomics #neurodegeneration #Parkinsons #alphasynuclein #structuralbiology #ethz
@imsb-eth.bsky.social @molsystbiol.org
Happy #FluorescenceFriday all!
Checkout these beautiful basal bodies in airway #multiciliated cells expanded via U-ExM 😍
Images captured by the super talented @maneesha07.bsky.social on a #Nikon NSPARC 🔬.
You are finishing your PhD and looking to continue in science?
The Martin lab @biology-unige.bsky.social has an open postdoctoral position in cell biology to study cell-cell fusion. For more information, please consult mocel.unige.ch/research-gro....
Thanks for reposting!
🧬 The Department of Biology at @univ-amu.fr will soon recruit a lecturer in Molecular Genetics & Genomics (Eukaryotes).
🧪 Apply with an eligible team: Bertrand; Delacour; Kodjabachian; Libé-Philippot; Mann; Schaeffer; Thomas.
Details: lnkd.in/eFS8qQpU
Our Lab is searching a postdoc for an exciting ERC-funded project that will start this summer. Apply if you’re passionate about multi-omics, cutting-edge computational approaches, and exploring biological questions across the animal 🪼 🪱 🐞 🦎 🦋 🕷️ tree of life www.biozentrum.unibas.ch/open-positio...
The best stories are the personal ones. So before we get to the new preprint, stay awhile and listen
#MobileLabs #TREC
But beyond the #Science ! This was undoubtedly the best #Human #experiment for me ! Putting enthusiastic scientists all together to find ways to better explore #Biodiversity in context ! & we have now hundreds of samples to look forward to !
way too many people to tag though in a post 😅
Cheers 😁
Excited to share our new preprint exploring how Paramecium achieves diverse flow functions, i.e. feeding and swimming, simultaneously. This work was spearheaded by our ExM expert, PhD student Daphne Laan @daphnelaan.bsky.social :
www.biorxiv.org/content/10.6...
For those on the job market, University of Toronto 🇨🇦 is hiring a tenure-track Assistant Professor in Zebrafish Models of Genetic and Metabolic Pathologies 🐟 Yes, they want #zebrafish!
🔗 jobs.utoronto.ca/job/Toronto-...
3D printing is way too much fun 😄
Just made myself a Titan Krios G5 pen holder 🧊🔬
Now the only thing missing… is McGill getting the real one! 😉
A new version of TubuleJ is available at github.com/dchretien35/...
It allows straightening of various kinds of fibers, and facilitates analysis of cryo-EM images of microtubules.
#CryoEM #microtubules
