🧪 Biomedical Picture of the Day from the Presynapse -

Nice very interesting idea.

Endoplasmic Reticulum Geometry Dictates Neuronal Bursting via Calcium Store Refill Rates and Exposes Selective Neuronal Vulnerability The ER's continuous tubular network is maintained by ER-shaping proteins whose mutation or dysregulation contributes to neurodegenerative diseases. Here, we show that ER morphology sets the speed of ...

🚨📜Our new paper out in @AdvSciNews:
ER shape matters for neuronal health - disrupting ER continuity halts neuro-firing as it slows Ca2+ store refill, explaining selective neuronal vulnerability to ER problems in neurodegeneration 🧠
a thread to follow advanced.onlinelibrary.wiley.com/doi/10.1002/...

Endoplasmic Reticulum Geometry Dictates Neuronal Bursting via Calcium Store Refill Rates and Exposes Selective Neuronal Vulnerability The ER's continuous tubular network is maintained by ER-shaping proteins whose mutation or dysregulation contributes to neurodegenerative diseases. Here, we show that ER morphology sets the speed of ...

🚨📜Our new paper out in @AdvSciNews:
ER shape matters for neuronal health - disrupting ER continuity halts neuro-firing as it slows Ca2+ store refill, explaining selective neuronal vulnerability to ER problems in neurodegeneration 🧠
a thread to follow advanced.onlinelibrary.wiley.com/doi/10.1002/...

🧪 Collective cognition in weaver ants?

wis-wander.weizmann.ac.il/space-physic...

🚨 #BSRA2026 is LIVE! Registration now open for our 75th Annual Meeting

📍 Oxford (Keble College)

Great science, great people, and some special 75th year surprises 👀

Tag someone who should be there!

🔗 meetinghand.com/e/75th-asm-o...

🧪 ‘Truly spectacular’ drug for sleeping sickness

Excited to share our new preprint on how membranes shape SNARE TMDs! www.biorxiv.org/content/10.6...

Please check out our newest work on fluorogenic speed imager probes, in which we combine the strengths of speed-optimized imagers and fluorogenic imagers.

#SuperResolution #DNAPAINT #microscopy

www.biorxiv.org/content/10.6...

HAIKU DIALOGUE – World of Animals – (Put Me in the Zoo) – long list - The Haiku Foundation

Going to the Zoo in Haiku

thehaikufoundation.org/haiku-dialog...

Functional rescue of a disease-linked ERAD pathway mutation via alternative splicing - The EMBO Journal ER-associated degradation (ERAD) targets misfolded proteins in the endoplasmic reticulum (ER) for proteasomal degradation. Mutations in its most conserved branch involving the SEL1L-HRD1 complex cause...

Huilun Helen Wang, Shengyi Sun, Ling Qi et al. serendipitously discover that mouse models expressing a fatal ERAD pathway mutation in SEL1L are rescued by alternative-splicing-mediated exclusion of the defective region
link.springer.com/article/10.1...

🚨📰Now online in its full form www.nature.com/articles/s41...

🚨📰Now online in its full form www.nature.com/articles/s41...

From the scientist's view: a conversation with Sean Munro YouTube video by MRC Laboratory of Molecular Biology

For our annual alumni newsletter, Sean Munro reflected on his time at the LMB, including how opportunity and curiosity have shaped his group’s research into the Golgi apparatus and his tenure as Head of Division for @cellbiol-mrclmb.bsky.social
Watch the interview: youtu.be/xFGb7_RmO9c

Vitamin B2 metabolism promotes FSP1 stability to prevent ferroptosis - Nature Structural & Molecular Biology Here, Deol et al. use genetic screens in gene-edited reporter cell lines to identify regulators of ferroptosis suppressor protein 1 (FSP1) expression and stability. They show that vitamin B2 metabolis...

1/3 Thrilled to see our paper led by Kirandeep Deol is out in Nature Structural & Molecular Biology! CRISPR screens to uncover a role for vitamin B2 metabolism in stabilizing FSP1 via FAD, revealing a new way vitamins regulate ferroptosis.
www.nature.com/articles/s41...

New preprint out!
In this study, we introduce NanoFLex, a strategy that combines #HaloTag variants with #nanobodies -based immunolabeling to enable rapid, OneStep-IF #lifetime #multiplexing. Possible due to SmartSecondaries fused to #HaloTag from @nanotag.bsky.social: www.biorxiv.org/content/10.6...

More great #bps2026 #SingleMolecule science on Monday! Sam’s poster (B393) identifies IDR function in HP1 protein homologs, and Xiaofeng’s poster (B178) describes combining 2D tracking and 3D simulations to measure how the nucleoid viscosity responds to cellular processes!

Ribosomal RNA expansion segments mediate the oligomerization of inactive animal ribosomes Cells down-regulate protein synthesis when stressed to conserve energy and shift resources toward repair. We found that in some mammalian cells, including neurons, stress also resulted in the formatio...

Out now in @science.org
Ribosomal RNA expansion segments mediate the oligomerization of inactive animal ribosomes | Science www.science.org/doi/10.1126/...

Thanks Felix, for your and Roger’s fantastic contribution. Your bespoke approach to visualisation of ER exit sites was truly invaluable

🙏

Thanks Edward, any time :)

🙏 This study was powered by fantastic collaborations — especially with @abelljonny.bsky.social & @joechambers.bsky.social with contribution form @felixmendu.bsky.social @lasergroup.bsky.social @franbottanelli.bsky.social 🔬🧠

www.nature.com/articles/s41...

Thanks Jonny for the generous creative effort, bottomless appetite to pushing the concept deeper. 🙏

Congrats Pierre and Edward!

Thanks Felix, for your and Roger’s fantastic contribution. Your bespoke approach to visualisation of ER exit sites was truly invaluable

🙏

Congratulations Edward and Pierre! Great work, I'm sure this will be a very useful tool for many in the field, including us :)

🙏 This study was powered by fantastic collaborations — especially with @abelljonny.bsky.social & @joechambers.bsky.social with contribution form @felixmendu.bsky.social @lasergroup.bsky.social @franbottanelli.bsky.social 🔬🧠

www.nature.com/articles/s41...

Our new paper's out: FidlTrack—structure-aware single-particle tracking benchmarks/boost SPT fidelity

With it we resolve with sub-organelle res. e.g. BACE1 amyloidogenic APP cleavage #Alzheimers, ER exit events, map nanobody binding in realtime in ER/organelles 🔬🧠#SingleMolecule

rdcu.be/e3Ris

ER remodelling is a feature of ageing and depends on ER-phagy - Nature Cell Biology Donahue et al. show that ageing is associated with changes in ER morphology. ER-phagy drives age-associated ER remodelling through tissue-specific factors.

☕Donahue et al. show that #aging is associated with changes in ER morphology. ER-phagy drives age-associated ER remodeling through tissue-specific factors. #autophagy #longevity
bit.ly/40dNHEE

Our new paper's out: FidlTrack—structure-aware single-particle tracking benchmarks/boost SPT fidelity

With it we resolve with sub-organelle res. e.g. BACE1 amyloidogenic APP cleavage #Alzheimers, ER exit events, map nanobody binding in realtime in ER/organelles 🔬🧠#SingleMolecule

rdcu.be/e3Ris

Good Morning! This week's selection of articles on #proteostasis thanks to @biomednews.bsky.social -- biomed.news/bims-proteo/...
Highlight: CRISPR screens in iPSC-derived neurons reveal principles of tau proteostasis www.cell.com/cell/fulltex...