New study from @ivanzheng.bsky.social and colleagues in the Dang lab @ragoninstitute.bsky.social reveals a spatial TH2-STAT6 immune checkpoint in pulmonary #granulomas that suppresses extracellular clearance of #Cryptococcus, promoting persistent infection. rupress.org/jem/article/...

None of this happens without an incredible team. Huge thanks to all authors and collaborators on this paper, and most importantly my mentor Dr. Eric Dang.
And thank you to editor Gaia @gaiajexpmed.bsky.social for the thoughtful handling of this work.

Alternatively activated monocyte-derived myeloid cells promote extracellular pathogen persistence in pulmonary fungal granulomas During latent pulmonary cryptococcal infection, Zheng et al. show that TH2-driven STAT6 signaling in monocyte-derived myeloid cells suppresses extracellula

Our paper is out in JEM @jem.org today. We show that Th2-driven STAT6 signaling in monocyte-derived myeloid cells actively suppresses extracellular fungal clearance during latent granulomatous cryptococcal infection. rupress.org/jem/article/...

Absolutely important finding showing that how epithelial cells coordinate the anti fungal immune response. Congrats to Kathleen and Tobias!!

Beautiful work, congrats!

Excited to announce a save the date for the upcoming Keystone Fungal Pathogenesis meeting! Jan 12-15 2026, mark your calendars! 🗓 Program and deadlines in link below
#microsky #immunosky #KSFungalPath26 🧪
www.keystonesymposia.org/conferences/...

Last week the 2025 GRC Immunology of Fungal Infections concluded. Thanks to @lableibundgut.bsky.social and @fungalspore.bsky.social for chairing this extraordinary meeting. See you in 2027

GRC fungal immunology is such a fantastic community. As a brand new member, I’ve received ton of help including suggestions for career development and my current project. I can’t easily imagine a senior PI coming to a postdoc and offering help proactively. I hope I can contribute in the future.

Fascinating! Congrats Peter and the whole team.

Mgl2+ cDC2s coordinate fungal allergic airway type 2, but not type 17, inflammation in mice Nature Communications - Fungal spores can promote immune responses of both type 2 (IL-4 / IL-5 / IL-13) and type 17 (IL-17). Here the authors characterise the subsets of cDC2 associated with type 2...

Delighted to see our study on #DendriticCell control of #fungal #allergic airway #inflammation finally out in the wild! Spearheaded by @drpetercook.bsky.social, with so many fantastic collaborators - thanks to all! #ImmunoSky 🧪
rdcu.be/d68MU @lydiabeckeriii.bsky.social @edinburgh-uni.bsky.social

C-LTMRs evoke wet dog shakes via the spinoparabrachial pathway Many hairy mammals perform rapid oscillations of their body, called wet dog shakes, to remove water and irritants from their back hairy skin. The somatosensory mechanisms that underlie this behavior are unclear. We report that Piezo2-dependent ...

“Wet dog shakes”—a common reflex behavior shared among many hairy mammals and designed to expel water and irritants from their coats—happens when particular mechanoreceptors are activated, researchers studying mice report in Science.

Learn more:

Thanks for your reply. Absolutely fascinating if virome/microbiota are involved.

Amazing work and commendable integrity. I have a question: what are your thoughts on the source of those Z-DNA/RNAs in damaged GI track? Do you think it’s simply due to the epithelial injury? And the body perceives them as some potential virus so to assemble complex to defend?

Merry Christmas.

Inflammation switches the chemoattractant requirements for naive lymphocyte entry into lymph nodes Lymph node swelling is a well-known symptom of infection. A shift in the chemoattractant code controls lymphocyte recruitment from blood into inflamed lymph nodes, allowing lymphocytes to accumulate so that even rare antigen-specific cells can encounter their activating antigen.

The power of oxysterols. Dr. Jason Cyster’s work is always fascinating.
www.cell.com/cell/fulltex...

A gut commensal protozoan determines respiratory disease outcomes by shaping pulmonary immunity The underlying mechanisms used by the intestinal microbiota to shape disease outcomes of the host are poorly understood. Here, we show that the gut co…

🎊 🙌🏼🙌🏼 Congratulations to Kyle Burrows and @theonlylabever.bsky.social

A gut commensal protozoan determines respiratory disease outcomes by shaping pulmonary immunity": www.sciencedirect.com/science/arti...

Our Editors’ Choice of articles published in #Science #Immunology this year is out now! This free sample collection will be available online to read until the end of February 2025!

bit.ly/SciImm_free

A taste of antiquity and a beauty of classical elegance.

So much fun in our Christmas party!

Science’s 2024 Breakthrough of the Year is lenacapavir, an injectable drug that demonstrated remarkable success at preventing HIV infection with one shot every 6 months. The drug attaches to the lattice-like capsid proteins that shield the virus’s genetic material—a mechanism that could inspire other antivirals. Lenacapavir could help end the HIV/AIDS epidemic, but that will hinge on access for those who need it most.

Science’s 2024 Breakthrough of the Year is lenacapavir, an injectable drug that demonstrated remarkable success at preventing HIV infection with one shot every 6 months.

Learn more about this year's #BOTY and other big advances in science: scim.ag/3BrCtUn

The story by Zhong and Zheng et al., where the cover came from, is about how microbiome affects the behavior of honeybees through metabolism alteration.

Recent favorite cover from Cell Host&Microbe @cellpress.bsky.social. I love the combination of science and art. Especially the picture is by traditional Chinese ink painting, quite fascinating.

Our annual "Best of JEM" series highlights some of the most exciting studies from the last 12 months. We present you with research in basic #immunology, #immunotherapy and tumor immunology, inborn errors of immunity, #neurodegeneration, & #inflammation: https://buff.ly/4iwWcCJ

🧬

The inflammatory microenvironment of the lung at the time of infection governs innate control of SARS-CoV-2 replication Recent or ongoing respiratory inflammation in the lung regulates antiviral immune responses to SARS-CoV-2.

🙏 to @niaidnews.bsky.social, first author @pauljbaker.bsky.social and my amazing lab team, our collaborators @kerryhilligan.bsky.social @danbarberphd.bsky.social 🙏to editor extraordinaire @hannah-isles.bsky.social and the reviewers who guided us along the way 9/9
www.science.org/doi/10.1126/...

*buy

lol, I hope I could help. Could you but insurance for the shipment by FedEX so that at least you could get refund if package missing?

Omg, that was horrible! I wonder if you could ship them by yourself then.