Ther Adv Med Oncol: Real‑world pyrotinib beyond progression vs rechallenge in HER2+ mBC (incl. brain mets): PFS2 ~7.2 vs 6.3 mo (NS); OS 31.6 vs 21.0 mo (trend). CNS subgroup also benefited. Read: 【🔗https://buff.ly/xsK4lFw 】 #BreastCancer #HER2 #BrainMets #Oncology

Analysis of 346 BCBM cases from the GEICAM RegistEM registry reveals faster CNS progression and poorer survival in TNBC and HER2+ subtypes, with major differences between de novo vs subsequent brain metastases.
🔗 buff.ly/74yHwuH
#BreastCancer #BrainMets #HER2 #TNBC #RealWorldEvidence

Clinical Trials Target Brain Metastases Veronica Chiang, MD, professor of neurosurgery, is currently leading several clinical trials seeking to improve treatments for brain metastases, or cancers that

Dr. Veronica Chiang shares updates on three #clinicaltrials she is leading that target brain metastases. #brainmets
medicine.yale.edu/news-article...

CME / CE - Physicians' Education Resource Physicians' Education Resource - Newest Continuing Medical Education Live Events, Webcasts & Online Activities

Thrilled to be part of the upcoming Brain & Spine Metastases Conference! Join me and colleagues to explore the latest in brain and spine mets. Use code Ahmed for a discounted rate! Register here: www.gotoper.com/brainspinemets #BMC25 #BrainMets #SpineMets

💡 Clinical Tip: In MBC (esp. HER2+ & TNBC), discuss brain metastasis risk proactively — patient-centered dialogue is key while awaiting trial evidence.
#BreastCancer #BrainMets #MetastaticBC #OncoTwitter #MedicalWatch

👉 Recently published in Clinical Cancer Research: A population-level real-world analysis and single-center validation of melanoma brain metastasis epidemiology following dual-agent immunotherapy 🔗 doi.org/10.1158/1078... #EANOessentials #NeuroOncology #BrainMetastases #brainMets #medsky

CIMARa has 4 goals:
1) Establish an infrastructure to enhance discovery & development of #brainmetstherapies
2) Provide a network of experts to advance & implement clinical trials for patients with #brainmets
3) Harmonize study end-points
4) Develop a common forum for discussion

Hello! Formally introducing CIMARa. Led by CareyAnders
(@dukemets.bsky.social) and @HTawbi_MD
(@mdanderson.bsky.social), we are physicians, scientists, non-profits & advocates who share the goal of improving outcomes for patients with #brainmets through awareness & coordination of research.

Happening now! Join us to learn from this great group of speakers. #CNS #pediatricbraintumor #braintumor #glioma #gbm #neurosurgery #brainmets #brainmetastasis

MDADI MDADI

Fine-tune your strategies for using #HER2 targeting tx in HER2+ #MBC with and without #BrainMets: Get expert insight in this video from @PeerView & @graspcancer.bsky.social featuring Sara A. Hurvitz, MD, FACP, and colleagues. bit.ly/4fk0wD5

Why are our findings significant?

Routine ERBB2 testing in EAC patients could guide early HER2-targeted therapy - and can identify high-risk patients for brain metastasis.

JAK2 alterations may help stratify patients for immunotherapy.

Thanks for reading!

#brainmets #oncology

Really excited to share our lab's first manuscript! I cant be more proud of our team, especially @nora-mae.bsky.social who diligently worked on this project.
It will be a long thread but I promise it's worth it!
#Oncology #BrainMets

.@drsgraff.bsky.social provides a clear overview of treatments for HER2+ MBC with a lot of discussion around those living with #brainmets. ADCs are now indicated for patients with active CNS disease #OncoAlertColloquium #BreastCancer

The late, great Laura Greco had 8 brain surgeries because of #BrainMets. Lung Cancer spreads to the brain more often than any other cancer.
We deserve better.
#LMD #lcsm

For Emma, losing her licence after a #LungCancer diagnosis with #BrainMets felt like losing her independence.

70% of #ALK+ pts get 🧠 mets, yet many don't get clear guidance on driving.

That’s why our DVLA Advisory Panel created this @pifonline.bsky.social certified guide #LCSM

📌 shorturl.at/k20oo

…or develop ways to deliver non-CNS-penetrant drugs to the central nervous system.

🔑 #OncSky #MedSky
We MUST include people w/ #brainmets, & as appropriate active untreated brain mets, in #Oncology #clinicaltrials. Preventing/treating CNS mets will be the final frontier in #bcsm.

/END

Breast cancer brain metastases genomic profiling identifies alterations targetable by immune-checkpoint and PARP inhibitors - npj Precision Oncology npj Precision Oncology - Breast cancer brain metastases genomic profiling identifies alterations targetable by immune-checkpoint and PARP inhibitors

#OncSky #bcsm

👉Remember this, esp in isolated #brainmets or isolated CNS progression
👉Determine if we can reliably detect same alterations in CSF (or innovate to make 🧠 biopsy ⬇️ invasive)
👉Prioritize CNS penetrant agents w/ 👌 safety for #drugdevelopment

/3

www.nature.com/articles/s41...

#MedSky #OncSky

NEW & IMPORTANT Genomic profiling performed on 822 #breastcancer #brainmets (BCBM) + thousands of local breast tumors & non-brain mets (unpaired).

🔑 HRD & #ImmunoOnc-predictive biomarkers are significantly more common in BCBM.

🔑 There were some diffs by #bcsm subtype.

/1

Now at #esmobreast24 it’s #BrainMets. Should we routinely screen? I know most MBC patients would say 👍🏻. Dr Emilie Le Rhun provides @myESMO guidelines. Brain mets are more common in HER2+ & TNBC, but can also occur in ER+. Brain mets also tend to occur sooner in TNBC.

via @NYTimes
watching a fascinating story on ⁦@60Minutes⁩ about Dr Ali Razai and the use of focused ultrasound to open the blood brain barrier to improved delivery of drugs to people with Alzheimer’s- this could be so impactful in #BrainMets...

.@MalladiLab talking about his lab’s work on #brainmets, in mouse models #MBCRC22

Tucatinib (Tukysa) in the HER2 Climb trial really changed the paradigm by allowing people with active #BrainMets to enroll. This is so important due to the high incidence of brain mets in HER2+ #MetastaticBreastCancer @cure_today #bcsm

Dr @AyalAizer should we be screening people with MBC for #brainmets routinely? There is trial in progress (will look later and add link to head later) #bcsm

what about drugs other than tucatinib for #brainmets in HER2+ MBC? Lots of encouraging data, and ongoing trials. #bcsm

Tucatinib is tyrosine kinase inhibitor that is super exciting, especially for those with active #brainmets. #bcsm

very interesting @UCSFBreastForum talk by Dr Claire Robertson, a materials scientist, on brain mets. Different subtypes of #breastcancer metastasize to different areas of the brain (white/yellow are more frequent sites) #brainmets #metastatic #bcsm

.@cure_magazine HER2CLIMB was THE story of 2019, given the response in people with #brainmets. Everyone with brain mets who did NOT get tucatinib had progression, but ~ 25% who got tucatinib had not progressed at 1 year! And it also lowered the risk of dying by 1 year!!!! #BCSM

#SABCS20 can we make any conclusions at this time whether tucatinib or netatinib should be used in people with #brainmets? This panel says can't really say since no head-to-head comparison, need to look at side effects profile and what may be more tolerable to each person. #bcsm

BUT ASCENT shows very little improvement of PFS in people with #brainmets treated with sacituzimab vs physician's treatment of choice. #sabcs20 #bcsm

#SABCS20 what about sacituzimab in #brainmets? 2/10 of the original patients with brain mets are still responding, with shrinkage of their brain mets. #bcsm