Chimeric autoantibody receptor T cells clonally eliminate B cells producing autoantibodies against IFN-γ Interferon-γ chimeric autoantibody receptor T cells broadly deplete autoreactive B cells against interferon-γ.

ICYMI: earlier this month in #Science #Immunology, Ping Chih-Ho & Cheng Lung-Ku labs engineered #CAART cells bearing truncated #IFNg mutant bait to eliminate #Bcells expressing anti-IFN neutralizing #autoantibodies (nAIGAs) in both mouse models & in ex vivo cultures of PBMCs from patients w/ nAIGAs!

"Paradise, The Morning After," needle felted (11"x17", 2019) - Depiction of the aftermath of the Camp Fire, wildfire that burned Paradise, CA

(In Private Collection)

Art by:
@meredithme.bsky.social #ecologyart #protestart #CAart #needlefelted #woolart

"Paradise, The Morning After," needle felted (11"x17", 2019) - Depiction of the aftermath of the Camp Fire, wildfire that burned Paradise, CA

(In Private Collection)

@blueskyartists.bsky.social #ecologyart #protestart #CAart #needlefelted #woolart

Chimeric autoantibody receptor T cells deplete NMDA receptor-specific B cells Anti-NMDA receptor (NMDAR) autoantibodies cause NMDAR encephalitis, the most common autoimmune encephalitis, leading to psychosis, seizures, and auton…

1/ Excited to share our latest research on Chimeric Autoantibody Receptor (CAAR) T cells targeting NMDA receptor-specific B cells! This could be a game-changer for treating #NMDAR #encephalitis.
www.sciencedirect.com/science/arti... #CAART #neuroscience #immunotherapy