An overview of the epigenetic mechanisms driving cancer stemness and treatment resistance, emphasizing the therapeutic potential of targeting these pathways to eradicate #CancerStemCell populations. @foxchasesurgonc.bsky.social

#OpenAccess: doi.org/10.1038/s413...

#Osimertinib disrupts the MYLK4–CDKAL1 interaction suppresses CDKAL1-dependent SALL2 translation, resulting in impaired #CancerStemCell maintenance and enhanced chemosensitivity in #Rhabdomyosarcoma.

#OpenAccess: doi.org/10.1038/s413...

A plastic EMP1⁺ to LGR5⁺ cell state conversion as a bypass to KRAS-G12D pharmacological inhibition in metastatic colorectal cancer Abstract. Inhibitors of the oncogene KRAS hold promise for treating metastatic CRC (mCRC). Here we show that a selective, covalent small molecule inhibitor of the active (ON) conformation of RAS-G12D,...

Cell plasticity as a mechanism to evade KRAS inhibition in colorectal cancer.

#KRAS #CellPlasticity #CancerStemCell 🧪

Precise targeting of YAP/TAZ reduces the expression of SOX2, disrupts mitochondrial oxidative phosphorylation, reduces sphere-formation, and induces apoptosis in breast #CancerStemCell enriched #Mammospheres. #medsky

#STTT #OpenAccess: doi.org/10.1038/s413...

Ferroptosis by nanomaterials: targeting cancer stem cells and overcoming drug resistance Ferroptosis-focused nanomaterials eradicate cancer stem cells and overcome drug resistance via iron-driven lipid peroxidation in precision oncology

Ferroptosis by nanomaterials: targeting cancer stem cells and overcoming drug resistance

amm-journal.org/index.php/20...

#Ferroptosis #drugresistance #cancerstemcell #nanomaterials