Silencing YAP/TAZ lowers SOX2 in #Mammospheres, reducing sphere formation and viability, modulating #RedoxHomeostasis, regulating mitochondria, and via DRP1 impairing #OXPHOS to eliminate #chemoresistant #brCSCs.

#STTT #OpenAccess: doi.org/10.1038/s413...

Precise targeting of YAP/TAZ reduces the expression of SOX2, disrupts mitochondrial oxidative phosphorylation, reduces sphere-formation, and induces apoptosis in breast #CancerStemCell enriched #Mammospheres. #medsky

#STTT #OpenAccess: doi.org/10.1038/s413...