Silencing YAP/TAZ lowers SOX2 in #Mammospheres, reducing sphere formation and viability, modulating #RedoxHomeostasis, regulating mitochondria, and via DRP1 impairing #OXPHOS to eliminate #chemoresistant #brCSCs.

#STTT #OpenAccess: doi.org/10.1038/s413...

First clinical results of XB2001, an IL-1α–targeting #antibody, show promising efficacy and safety in #chemoresistant #mCRC when combined with FTD/TPI and #bevacizumab, demonstrating improved PFS and reduced IL-6 levels. #medsky

#OpenAccess in #STTT: doi.org/10.1038/s413...

Mitochondrial-targeting strategies with homoharringtonine: A novel approach for chemoresistant rectal cancer - PubMed 5-Fluorouracil (5-FU) resistance poses a significant challenge in the treatment of rectal cancer, driving the need for novel therapeutic strategies. In this study, we established 5-FU-resistant rectal...

Mitochondrial-targeting strategies with homoharringtonine: A novel approach for chemoresistant rectal cancer! #TCSC #rectalcancer #chemoresistant #chemo

pubmed.ncbi.nlm.nih.gov/39681051/