Meningeal vascular remodeling in 2~4 mo ovariectomized🐭
⏬blood vessel length
⏫blood vessel tortuosity
⏫PDPL+ lymphatic vessel area fraction
Ectopic vessel muscularization
Perivascular scattered αSMA+ cells in dura mater

#Cells_MDPI 2025
www.mdpi.com/2073-4409/14...

#Pericyte #Retina

Pericyte Vegfa KO🐭
👉⏬Vascular radial outgrowth, sprouting tip cells P5
down P5
👉↔️Arterial patterning, fundus integrity, vascular permeability, OIR vessel obliteration/neovascularization, laser-induced CNV
👉Pericyte# ⬇️3 wk ⬆️6 mo

#Cells_MDPI 2025
www.mdpi.com/2073-4409/14...

Serial block-face SEM of mouse Heart Capillaries #EndothelialCell #Pericyte #Telocyte

There are direct physical contacts b/w CD34+/CD44+ perivascular mesenchymal cells & abluminal protrusions of EC!

#Cells_MDPI 2025
www.mdpi.com/2073-4409/14...

Gene–Environment Interaction: Small Deletions (DELs) and Transcriptomic Profiles in Non-Melanoma Skin Cancer (NMSC) and Potential Implications for Therapy Arsenic (As) is a risk factor for non-melanoma skin cancer (NMSC). From a six-year follow-up study on 7000 adults exposed to As, we reported the associations of single-nucleotide variation in tumor ti...

Researchers from the University of Chicago published a new study in #Cells_MDPI demonstrating an association between arsenic exposure and small deletions in genes linked to non-melanoma skin cancer.
#UChicagoPHS #Uchicago_IPPH
www.mdpi.com/2073-4409/14...

#TunnelingNanoTube mediates Pericyte-to-Endothelial Cell Mitochondrial transfer

Retinal Pericyte TNT⏫in diabetic 10-mo Ins2Akita🐭

An impressive LC-MS/MS metabolomics showing how Pericyte coculture rescues TCA cycle defects in Mitochondria-depleted EC

#Cells_MDPI 2024
www.mdpi.com/2073-4409/13...

#SmoothMuscleCell #RNAEditing ADAR1
Adult SMC Adar1 KO🐭->
1⃣100% mortality
2⃣Arterial rupture/hemorrhage in multi-organs (Brain/Lung/GI, also Aorta?)
3⃣SMC mitochondrial dysfunction + apoptosis
4⃣Extensive elastin thinning & breaks

#Cells_MDPI 2024
www.mdpi.com/2073-4409/13...

FASN/#FattyAcidSynthase #SmoothMuscleCell - #FoamCell transition

Cholesterol->⏫FASN->⏫KLF4->
⏬ABCA1 (cholesterol efflux)
⏫SOAT1 (cholesterol esterification)

Alejandra San Martin lab #Cells_MDPI 2024
www.mdpi.com/2073-4409/13...

Direct effects of Cannabidiol (up to 6 μM) on cultured👤coronary arterial #SmoothMuscleCell

⏫PDGF-induced metabolism (WST-1), proliferation
⏬PDGF-induced migration, LPS/IL1β-induced VCAM1 (not ICAM1) (Independent of CB1/CB2/TRPV1)

#Cells_MDPI 2023
www.mdpi.com/2073-4409/12...