STARD4 promotes the proliferation, #Metastasis, and #Lenvatinib resistance in #HCC by modulating #CholesterolHomeostasis and activating the EGFR/PI3K/AKT pathway, positioning it as a potential #Biomarker and #TherapeuticTarget.

#OpenAccess: doi.org/10.1016/j.ge...

Targeting STARD4/EGFR axis inhibits growth and overcomes lenvatinib resistance in hepatocellular carcinoma

This study shows that STARD4 enhances #HCC growth and lenvatinib resistance by regulating #CholesterolHomeostasis and activating the EGFR/PI3K/AKT pathway, thereby establishing it as a promising therapeutic target for HCC treatment. #medsky

#OpenAccess: www.sciencedirect.co...

Targeting STARD4/EGFR axis inhibits growth and overcomes lenvatinib resistance in hepatocellular carcinoma

This study shows that STARD4 enhances #HCC growth and lenvatinib resistance by regulating #CholesterolHomeostasis and activating the EGFR/PI3K/AKT pathway, thereby establishing it as a promising therapeutic target for HCC treatment. #medsky

#OpenAccess: www.sciencedirect.co...