Great talk by Phillip Yesley from the group of Wim Velema at #Lunteren2026.

He discussed the use of mutational profiling to find covalent ligands for structured #RNA using acyl imidazoles as the reactive group.

onlinelibrary.wiley.com/doi/10.1002/...
#ChemSky #ChemBio #Covalent #CovalentInhibitor

Covalent Enhances Its ISO/IEC 17025 Accreditation with Sixty Services Covalent has expanded its ISO/IEC 17025 accreditation to include a total of sixty analytical and metrology services, enhancing its capabilities in materials characterization.

Covalent Enhances Its ISO/IEC 17025 Accreditation with Sixty Services #United_States #Sunnyvale #Materials_Analysis #Covalent #ISO/IEC_17025

Covalentと連携し、欧州サイバーレジリエンス法に対応するサービスを展開 アシュアードがCovalentと協力し、2026年施行の欧州サイバーレジリエンス法を見据えた支援サービスを提供。ウェビナーも開催！

Covalentと連携し、欧州サイバーレジリエンス法に対応するサービスを展開 #東京都 #渋谷区 #yamory #アシュアード #Covalent

アシュアードがCovalentと協力し、2026年施行の欧州サイバーレジリエンス法を見据えた支援サービスを提供。ウェビナーも開催！

It's easy to see the differences between #covalent, #ionic, #metallic bonding & intermolecular forces with our paper models!
Covalent: buff.ly/yCR2AFd
Ionic: buff.ly/OAQYzX2
Metallic: buff.ly/MvpM32W
Intermolecular forces: buff.ly/duQEVSU

#EduSky #iteachchem #chemistry

Li et al (2026) Mechanistically Defined Epoxide- and Aziridine-2-carboxamide Electrophiles Enable Stereoselective #Covalent #RNA Modulation #DrugDiscovery #MedChem #cheminformatics #bioXriv #preprint #chemsky 🧪
doi.org/10.64898/202...

Covalent Rebranding: A New Era of Material Insights and Expanded Services Covalent Metrology has rebranded to Covalent, showcasing its expanded capabilities in material insights, analysis, and consulting services for various industries.

Covalent Rebranding: A New Era of Material Insights and Expanded Services #USA #Sunnyvale #Metrology #Covalent #Material_Insights

Amazing lecture by Chu Wang at #ISCPDD. He talked about the use of a group competition strategy to identify #covalent ligands using #ChemicalProteomics. A great approach that allows the screening of multiple ligands against many proteins at once.
#ChemSky #ChemBio #DrugDiscovery

📢 #Covalent, Covalent Strategic Reserve’in lansmanını duyurdu.

Şirket, zincir içi ve zincir dışı gelirlerle finanse edilen, çok yıllı kilitli bir rezerv olan Covalent Strategic Reserve’i hayata geçirdi. Rezerv kapsamında, düzenli $CXT geri alımları da yer alıyor.

The types of chemical bonds seen in materials are responsible for their properties... but how can you show this? Our #Covalent, #Ionic, #Metallic Bonding & Intermolecular Forces paper models show the differences in how electrons behave! Find out more here: buff.ly/9qTQe5g

#EduSky #iteachchem

H©Cu4I4–: A Planar Tetracoordinate Hydrogen Superhalogen Anion Stabilized by Covalent Multicenter Bonding | Inorganic Chemistry pubs.acs.org/doi/10.1021/... Guo and co-workers @InorgChem #copper #hydrogen #superhalogen #H_Cu4I4minus #ptH #GM #CK #covalent

COOKIE-Pro: covalent inhibitor binding kinetics profiling on the proteome scale - Nature Communications A significant challenge in modern drug development is the comprehensive profiling of covalent inhibitors. Here, the authors develop COOKIE-Pro, an unbiased method for quantifying the binding kinetics of irreversible covalent inhibitors on a proteome-wide scale.

Lin et al (2025) COOKIE-Pro: #covalent #inhibitor binding #kinetics profiling on the proteome scale. Nat Commun 16 8373 #DrugDesign #DrugDiscovery #ChemBiol #MedChem #cheminformatics #OpenAccess #chemsky 🧪
doi.org/10.1038/s414...

Antiparallel Dynamic Covalent Chemistries. LATEST UPDATED VERSION
#Antiparallel #DynamicCovalentChemistries #Dynamic #Covalent #Chemistries #chemistry #convalentChemistries #dynamicChemistries #antiparallelChemistries

www.stuvia.com/doc/9198788/...

⚡ Flash News ⚡

💥 Sonic integrated into Covalent’s Data Co-Processor 🚀

Covalent added Sonic to its sub-second Data Co-Processor, enabling instant on-chain data via GoldRush APIs while returning up to 90% of fees to dApps.

#Covalent #Sonic #GoldRush #Web3 #blockchain

It's easy to see the differences between #covalent & #ionic bonding with our paper models! Seeing the way electrons behave makes all the difference. Find out more here -
Covalent: buff.ly/bG4aL2J
Ionic: buff.ly/oAMnKIz

#EduSky #iteachchem #chemicalbonds #chemistry

48 grants for the Open Competition Domain Science- XS | NWO 48 projects will receive 2.4 million euros from the Open Competition Domain Science- XS round 25-2. The subjects vary from identification of the most effective fungal cutinase for plastic recycling to comparing gene expression and cellular behaviour of these scar-forming cells with cells from pulmonary emboli that do not show scars.

Excited that our group was awarded an NWO XS grant to support our research into new #covalent #antibiotics for Gram-negative bacteria!

Thank you to Storm van der Voort for help with the proposal.
Congratulations also to all other recipients of the grant!
www.nwo.nl/en/news/48-g...
#ChemSky #ChemBio

From cheers to tense sighs: results Kiem lottery 2025 announced - Leiden University At a festive gathering, 25 projects were awarded a Kiem grant 2025 - 2026 of 10,000 euros. Interdisciplinary teams from Leiden University will conduct innovative research into horror, international payments and fungi in historical collections, among others.

Excited that our group was awarded a KIEM grant in collaboration with the @smitslab.bsky.social. Using this grant, we will establish establish new interdisciplinary connections and explore the development of #covalent #antibiotics against C. difficile.

www.staff.universite...

Matchpoint Therapeutics Announces Exclusive Option and License Agreement with Novartis to Develop Oral Inhibitors for Multiple Inflammatory Diseases - Matchpoint Therapeutics Matchpoint Therapeutics Announces Exclusive Option and License Agreement with Novartis to Develop Oral Inhibitors for Multiple Inflammatory Diseases

Matchpoint Therapeutics announces exclusive option and license agreement with #Novartis to develop oral #covalent inhibitors directed at an undisclosed transcription factor linked to several inflammatory diseases

$60 million upfront and up to $1 billion total deal

matchpointtx.com/news/matchpo...

Covalent Drug Discovery: Challenges, Advances, and Success Stories - International Pharmaceutical Industry Covalent inhibitors possess a functional group that reacts with a nucleophilic residue on a target protein to form a bond that inhibits the protein’s

Thanks to International Pharmaceutical Industry for publishing our article on #covalent inhibitors written by Andrew Ratcliffe and Scott Martin.
international-pharma.com/covalent-dru...
#DrugDiscovery

Emerging and Re-Emerging Warheads for Targeted Covalent Inhibitors: Applications in Medicinal Chemistry and Chemical Biology Targeted covalent inhibitors (TCIs) are designed to bind poorly conserved amino acids by means of reactive groups, the so-called warheads. Currently, targeting noncatalytic cysteine residues with acrylamides and other α,β-unsaturated carbonyl compounds is the predominant strategy in TCI development. The recent ascent of covalent drugs has stimulated considerable efforts to characterize alternative warheads for the covalent-reversible and irreversible engagement of noncatalytic cysteine residues as well as other amino acids. This Perspective article provides an overview of warheads—beyond α,β-unsaturated amides—recently used in the design of targeted covalent ligands. Promising reactive groups that have not yet demonstrated their utility in TCI development are also highlighted. Special emphasis is placed on the discussion of reactivity and of case studies illustrating applications in medicinal chemistry and chemical biology.

Fanboy moment for me today at #FocusOnCovalentDrugs. Hearing Matthias Gehringer present for the first time. His reviews on covalent warheads are a must-read in my group for many years now.

#ChemSky #ChemBio #DrugDiscovery #covalent

pubs.acs.org/doi/10.1021/...
pubs.acs.org/doi/10.1021/...

Image shows graphs for Kinact/KI and Kobs, maximum percentage of binding and Koff.

We have established assays for determining Kinact/Ki (for irreversible #covalent inhibitors) and for determining Kobs, maximum percentage of binding, and Koff rate (for reversible covalent inhibitors).
Find out more:
www.domainex.co.uk/services/kin...
www.domainex.co.uk/services/rev...

The flash talk session and the posters were a highlight of #ABPP2025. We heard a lot of exciting research into #covalent #fragment screening, #antibiotic development, #microbiome activities, posttranslational modifications #PTMs and lysine-directed #kinase inhibitors.
#ABPP #ChemSky #ChemBio

Text reads: At Domainex, our scientists are highly skilled and experienced in the design, synthesis and testing of both reversible and irreversible covalent inhibitors In-house covalent fragment library available Established workflows for both reversible and irreversible covalent fragments including: Mass-spectrometry (MS) based assay, Glutathione (GSH) reactivity assay (for irreversible inhibitors), Binding site identification by peptide mapping, Determination of the second order rate constant Kinact/Ki (for irreversible inhibitors), Determination of Kobs, maximum percentage of binding, and Koff rate (for reversible inhibitors), Structural biology characterisation

Do you need support for your #covalent inhibitor programme? Whether you need help identifying initial hits, optimising hits you've already identified, or profiling your covalent compounds, #Domainex has the expertise to drive your project forward.
www.domainex.co.uk/services/cov...
#FBDD

The latest issue of ACS Applied Materials & Interfaces (@ACS_AMI) is live! On the cover: “Enhanced #Removal of Ultratrace Levels of #Gold from #Wastewater Using Sulfur-Rich #Covalent #Organic #Frameworks”

Great keynote lecture by @martola.bsky.social of the @led3hub.bsky.social at #Lunteren. She talked about the importance of glycosidases in various diseases and her great work on conformationally locked #covalent and non-covalent #inhibitors and #probes.
#chemsky #ChemBio
pubs.acs.org/doi/10.1021/...

Although this reaction proceeds in a SMARCA-independent manner in vitro (potentially due to artificially high compound & protein concentrations), the true event may proceed through template-assisted #covalent modification, akin to the DCAF16-recruiting BRD4 degraders of Nathanael Gray et al.

Boeing Partners with Covalent for Advanced Training Solutions in Manufacturing Boeing has chosen Covalent’s Capability Management solution for structured on-the-job training to enhance workforce efficiency and effectiveness across its global manufacturing sites.

Boeing Partners with Covalent for Advanced Training Solutions in Manufacturing #United_States #Boston #Workforce_Training #Boeing #Covalent

DataRobotがAgnostiqを買収しAIエージェントの未来を加速 DataRobotは、AIエージェントの開発を加速するためにAgnostiqを買収しました。これにより企業は柔軟にAIを管理できるようになります。

DataRobotがAgnostiqを買収しAIエージェントの未来を加速 #DataRobot #Covalent #Agnostiq

DataRobotは、AIエージェントの開発を加速するためにAgnostiqを買収しました。これにより企業は柔軟にAIを管理できるようになります。

Covalent Organic Frameworks for Membrane Separation The application of covalent organic frameworks (COFs) in membrane separation represents a significant breakthrough in materials science. This review explores the preparation strategies, synthesis met...

Our latest review article on #Covalent #Organic #Frameworks for #Membrane Separation / #COF | Advanced Science | Wiley advanced.onlinelibrary.wiley.com/doi/10.1002/...