Orally Bioavailable Cyclin A/B RxL Inhibitors: Optimization of a Novel Class of Macrocyclic Peptides That Target E2F-High and G1–S-Checkpoint-Compromised Cancers Cyclins A and B bind and activate their cognate cyclin-dependent kinase (CDK) to regulate progression through the S and G2/M phases of the cell cycle, respectively. Cyclins recruit substrates and regu...

1/2: I'm not too old but I never thought I'd see a believable #cyclin targeting drug in my lifetime.

Kudos to the effort it took to make this peptide look more like a small molecule and we'll see what happens in the clinic.

pubs.acs.org/doi/10.1021/...

Riders avatars in sky blue kit riding towards green mountains on Zwift

🚴‍♂️ ⏰ 01:20:48 📏 31.82 km 🛫 790 m+ ❤️‍🔥 150 bpm 🪫 161 w 🧁 748 kcal

My 'easy' Velos group ride turned out to be anything but, crawling up Watopia's radio tower on Radio Rendezvous the whole ride.
🔖 #cyclin... https://l.prry.uk/training-log/2026-02-24-evening-ride/

Anaphase onset requires CKS-1 mediated destruction of securin in #meiosis I and #cyclin B1 in meiosis II, say Jie Yang, Eisuke Sumiyoshi, and Bruce Bowerman @uoregon.bsky.social: rupress.org/jcb/article/...

#CellCycle #CellDivision #Genetics #Celegans

Yang et al. show that #Celegans CKS-1 is required, with CDK-1, for #anaphase B during #oocyte #meiosis I; promotes anaphase onset through securin & #cyclin B1 destruction in meiosis I & II, respectively; and acts positively with both securin and cyclin B3 in meiosis II. rupress.org/jcb/article/...

In @jcb.org, Yang et al. show that #Celegans CKS-1 is required, w CDK-1, for anaphase B during oocyte meiosis I; promotes anaphase onset thru. securin & #cyclin B1 destruction in meiosis I & II, respectively; & acts positively with both securin and cyclin B3 in meiosis II rupress.org/jcb/article/...

Today’s cycling food is brought to you by the letter “P” for pancakes! 😂
#cycling #bikesky #bicycling #mtb #cyclinglife #cyclinglove #bike #bikelife #bikelovers #roadcycling #cyclingpics #cycle #mtblife #cyclin #foodsky #breakfast #food #recipes #eat #eats #meal #meals

Differences in control of separase activity between meiosis and mitosis. Separase activity in mitosis is controlled by at least three different pathways: a specific protein inhibitor called securin; phosphorylation and binding to Cyclin/CDK1; and the Mad2/SGO2 complex. According to the results of the new study by Wetherall and colleagues [9], the Mad2/SGO2 complex does not play a role in separase control in oocytes.

Separase plays a key role in cleaving #cohesin complexes during cell division. Martin Anger explores a @plosbiology.org study showing that #separase activity is controled by #cyclin B/CDK1 & securin in #meiosis (and not SGO2, as in mitosis) 🧪 Paper: plos.io/3RAoccz Primer: plos.io/43L91UR

Differences in control of separase activity between meiosis and mitosis. Separase activity in mitosis is controlled by at least three different pathways: a specific protein inhibitor called securin; phosphorylation and binding to Cyclin/CDK1; and the Mad2/SGO2 complex. According to the results of the new study by Wetherall and colleagues [9], the Mad2/SGO2 complex does not play a role in separase control in oocytes.

Separase plays a key role in cleaving #cohesin complexes during cell division. Martin Anger explores a @plosbiology.org study showing that #separase activity is controled by #cyclin B/CDK1 & securin in #meiosis (and not SGO2, as in mitosis) 🧪 Paper: plos.io/3RAoccz Primer: plos.io/43L91UR

Differences in control of separase activity between meiosis and mitosis. Separase activity in mitosis is controlled by at least three different pathways: a specific protein inhibitor called securin; phosphorylation and binding to Cyclin/CDK1; and the Mad2/SGO2 complex. According to the results of the new study by Wetherall and colleagues [9], the Mad2/SGO2 complex does not play a role in separase control in oocytes.

Separase plays a key role in cleaving #cohesin complexes during cell division. Martin Anger explores a @plosbiology.org study showing that #separase activity is controled by #cyclin B/CDK1 & securin in #meiosis (and not SGO2, as in mitosis) 🧪 Paper: plos.io/3RAoccz Primer: plos.io/43L91UR

Ride screenshot from TPVirtual showing a lake to the left and mountain on the horizon below a dark moonlit sky

⏱️ 00:28:20 🛣️ 10.61km ⛰️ 244m+ 🪫 189W ❤️‍🔥 156bpm 🍔 319kcal
Testing new saddle position on Loched and Loaded. Loads of power, but a little hip pain - so need to tweak slightly lower, slightly nearer. #cyclin... lee-perry.co.uk/activities/2025-03-11-ev...

High-throughput discovery and deep characterization of cyclin-CDK docking motifs Cyclin-CDKs are master regulators of cell division. In addition to directly activating the CDK, the cyclin subunit regulates CDK specificity by binding short peptide “docking” motifs in CDK substrates...

Happy to have made a minor contribution to this fabulous study by Dr. Örd on #cyclin docking #motifs showing that they vary from highly selective to pan-cyclin. Great collaboration with Pryciak & Davey labs. www.biorxiv.org/content/10.1...

Lime Green Women's Short Sleeve Cycling Kit Jersey: 100% Polyester
Pants: 80% Polyester and 20% Spandex
Pad: 20D Silicone GEL breathable pad
$45.99 shareasale.com/r.cfm?b=2369...

#Bike #style #fashion #Casual #designer #business #Spandex #Cyclin #Silicone #Jersey #Pants #Shirt

Latest news and today's top stories | Yahoo News UK Keep up-to-date with what's going on in the UK and around...

Idiotic cycle lane marking in Stevenage. http://yhoo.it/R799n3 #cyclin #cyclesafe How about applying an ounce of common sense