Epigenetics Update - Dynamic association of H3K36me3 with pericentromeric heterochromatin regulates its replication time bit.ly/3IhhrLw

From M Cristina Cardoso (University of Darmstadt)

#Epigenetics #H3K36me3 #Heterochromatin
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Gain deeper insights into gene regulation; epigenometech.com

A SETD2–CDK1–lamin axis maintains nuclear morphology and genome stability - Nature Cell Biology Khan et al. report a non-catalytic function of the methyltransferase SETD2 in regulating nuclear morphology and genome integrity. The SETD2 amino terminus functions as a scaffold helping CDK1 associat...

Epigenetics Update - A SETD2–CDK1–lamin axis maintains nuclear morphology and genome stability go.nature.com/4mgxhVM

Brian D. Strahl (U at Chapel Hill) reporting in Nat Cell Biol

#Epigenetics #SETD2 #H3K36me3
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Perfect for cancer, immunology, and aging research; epigenometech.com

Epigenetics Update - KDM4C inhibition blocks tumor growth in basal breast cancer by promoting cathepsin L-mediated histone H3 cleavage go.nature.com/4kmvWLR

#Epigenetics #H3K9me3 #H3K36me3
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High-resolution insights with no cell sorting; find out more at epigenometech.com

Congrats! Very cool!
#SETD2 #H3K36me3 #Histone #Transcription #PTM #Structure

CD: Switch between #H3K36me3 ⬆️ #H3K27me3 ⬇️ to activate of repress FLC and regulate flowering in response to cold in Arabidopsis. Individual cells are either ON or OFF - quantitative response depends on % of cells in either state resulting in epigenetic memory of cold exposure.