Multiple origins and functions: evolutionary pathways of HSP70 proteins in viruses Heat shock protein 70s (HSP70s) are highly conserved molecular chaperones found across all domains of life, where they play essential roles in cellular stress responses. Whilst HSP70 homologues have been previously identified in closteroviruses that have ssRNA genomes, their broader presence and evolutionary history in viruses remain poorly understood. In this study, we conducted a comprehensive search of viral protein databases and identified HSP70 homologues in viruses beyond those with ssRNA genomes, including examples with dsDNA genomes in the class Megaviricete. These viral HSP70s exhibit diverse gene organizations, copy numbers and structural features. Notably, HSP70s of viruses from Megaviricetes showed up to three gene copies per genome and distinct structural motifs, whilst those from closteroviruses displayed higher sequence and structural diversity, suggesting faster evolutionary rates. Structural and phylogenetic analyses revealed two major clusters of viral HSP70s, with dsDNA virus HSP70s closely resembling those of their protist hosts, supporting the hypothesis of horizontal gene transfer. In contrast, ssRNA virus HSP70s formed a distinct, highly divergent group. Our findings suggest multiple independent acquisitions of HSP70 genes by viruses and provide new insights into their evolutionary trajectories and potential functional adaptations.

Virus HSP70s show multiple independent origins, with distinct evolutionary paths in ssRNA and dsDNA viruses, highlighting #HorizontalGeneTransfer and functional diversification.🧬🔥#Virology #Evolution #HSP70 #MolecularEvolution
📄https://doi.org/10.1099/jgv.0.002242
👤EVBC: Santiago F. Elena

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Okayama University Unveils Mechanism for Photosynthesis Under Stress Conditions Okayama University has discovered how plants maintain photosynthesis under stress by utilizing a new mechanism involving HSP70 proteins and lipid remodeling.

Okayama University Unveils Mechanism for Photosynthesis Under Stress Conditions #Japan #Okayama #Okayama_University #VIPP1 #HSP70

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Research conducted in Australia utilized StressMarq's #HSP70 Antibody to investigate the impact of exercise on age-related muscle decline. Data suggest that physical activity may modulate stress proteins.

Paper 🏃‍♀️ https://bit.ly/4pnLWzc
Product ⛳ https://bit.ly/45ufkML

Nice new review on #Hsp70 and its network of chaperone friends and clients - by Anne Wentink, Rina Rosenzweig, Harm Kampinga and Bernd Bukau #chaperones #amyloid

Pancreatic Cancer Drug. University of Cincinnati oncologists have developed a drug that stops pancreatic cancer from suppressing the anti-tumor immunity that threatens to eradicate it. #pancreatic #cancer #immunotherapy #hsp70 #sapCDOPG

DNAJC9 integrates heat shock molecular chaperones into the histone chaperone network Hammond et al. identified and characterized a histone chaperone functionality in the heat shock co-chaperone DNAJC9. DNAJC9 directs molecular chaperones to histone substrates, facilitating their suppl...

Old news: Welcome to the 🌍 of histone chaperones DNAJC9 🛸. Hammond et al 2021 “DNAJC9 Integrates Heat Shock Molecular Chaperones into the Histone Chaperone Network” is open for access @ Molecular Cell. tinyurl.com/yh9yduuf #chromatin #histone #chaperone #hsp70. Let's unravel this 🧵