#HistoneLactylation #Angiogenesis

VEGF-A➡️
⏫#EndothelialCell #Glycolysis #Lactate➡️
⏫H3K9la➡️
>50% CUT&Tag peaks within 3 kb promoters
Covering prolif/motility/junction/hypoxia

Oxygen-induced retinopathy ⬇️ by glycolytic inhibitors

#GenomeBiol 2024
genomebiology.biomedcentral.com/articles/10....

Biochemistry and regulation of histone lysine l-lactylation - Nature Reviews Molecular Cell Biology Lys l-lactylation of histones is a newly identified short-chain acylation that regulates transcription and other cellular processes, with diverse pathophysiological outcomes, notably in cancer. This R...

Epigenetics Reviews - Biochemistry and regulation of histone lysine l-lactylation go.nature.com/4mhh16I

Yingming Zhao (University of Chicago) reporting in Nat Rev Mol Cell Biol

#Epigenetics #Reviews #HistoneLactylation
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High-resolution insights without cell sorting; epigenometech.com

Another lactate dependent immunosuppressant mechanism, here in Glioblastoma

#GBM #Lactate #CD47 #HistoneLactylation

JCI - Lactate reprograms glioblastoma immunity through CBX3-regulated histone lactylation www.jci.org/articles/vie...