#ISGylation by #ubiquitin-like #ISG15 can fight or fuel viruses ⚔️ – and is key in the #CNS too 🧠 #virology #neurobiology
➡️ doi.org/10.1002/1873-3468.70063

Cool paper! #ISG15 #ISGylation

SARS-CoV-2 papain-like protease inhibits ISGylation of the viral nucleocapsid protein to evade host anti-viral immunity | Journal of Virology ISG15 is an interferon-inducible ubiquitin-like protein that is covalently conjugated to the viral protein via specific Lys residues and suppresses viral functions and viral propagation in many viruse...

#MedSky🧪 #IDSky #ImmunoSky These results suggest that the novel #SARSCoV2 is simply better at evading by #SARSCoV2 papain-like protease that can remove the tags ( #ISGylation journals.asm.org/doi/10.1128/... )