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Come get your curated #immune #assays from 1,000s of human subjects at our website
immunespace.org
🧪 #immunology #IDSky #ImmuneSky
immunespace.org/query/filters

giphy.com/gifs/Giflyti...

Illustration of some neutrophils

Illustration of some lymphocytes

🎨🔬 I just released some simple immune cell illustrations I've made over time for my talks, for anyone to use in their talks, teaching, or outreach!
No attribution required, just not for commercial use.
You can download them from my github 👉 github.com/goboru/cell-...
#SciComm #Immunesky #sciart

Against a green background, a pattern of consecutive rings has small round faces or icons. Each represents an institution or person who is connected with the center image - Human Immunology Project Consortium. A gov't financed research project aimed at understanding the human immune system.

We are a network of 8 big members:
@lji.org @columbiamed.bsky.social @yalemedicine.bsky.social MIT @seattlechildrens.bsky.social
@stanfordimmunology.bsky.social
Icahn Mt. Sinai @benaroyaresearch.bsky.social
You can upload our #free data at immunespace.org
Image from 2020. 🧪 #ImmuneSky

ADTnorm: robust integration of single-cell protein measurement across CITE-seq datasets - Nature Communications Here the authors present a computational method that expands the potential of multimodal single-cell analyses by delivering an accurate, fast, and user-friendly approach for normalizing and comparing ...

Our collaborators @rgottardo.bsky.social Peter Sims and Ken Stuart (and others) develop tool ADTNorm, a method of helping noisy CITE-seq data to be "normalized"
#antibody
#ImmuneSky

nature.com/articles/s41...

#CITEseq #SingleCell #ADTNorm

Page shows information about Human Immunology Project Consortium and the data from 174 studies, 52 diseases. https://immunespace.org

Our project spans 8+ institutions, with human cohorts studied with multiplex transcriptional, #cytokine, and #proteomic assays; multiparameter #phenotyping of leukocyte subsets + many computational methods.
Get our #data for your own investigations.
#ImmuneSky #IDsky
immunespace.org

Our collaborator Purvesh Khatri writes in preprint on new tool for #single-cell analysis called scMetaIntegrator.
The method provides robust effect size estimates and reproducible p-values.
#ImmuneSky
@stanfordimmunology.bsky.social
@biorxivpreprint.bsky.social
www.biorxiv.org/content/10.1...

Neuroimmune pathophysiology of long COVID Although COVID-19 was originally considered a respiratory illness, it is now well established that SARS-CoV-2 infection can have far-reaching impacts on the nervous system. Neurological symptoms such....

Our collaborator @virusesimmunity.bsky.social
and others review the #neuro #immunology of #LongCovid
#IDSky #ImmuneSky
onlinelibrary.wiley.com/doi/10.1111/...

Cell simulation as cell segmentation - Nature Methods Proseg is a segmentation approach for single-cell spatially resolved transcriptomics data that uses unsupervised probabilistic modeling of the spatial distribution of transcripts to accurately segment...

Our collaborator @evnewell.bsky.social + others
outline a new approach to identifying tumor-infiltrating #immune cells from spatial #transcriptomics. They explore cell segmentation methods .
@nature.com
@hutchinnovation.bsky.social
#ImmuneSky

www.nature.com/articles/s41...

A page from a website shows the words "Why Use ImmuneSpace Data" at the top and numbers describing the quantity of immune data included.

Come visit immunespace.org for free #data (+ pubs) from > a decade, new projects
( @cuimcmedicinedept.bsky.social
MIT, @yaleschoolofmed.bsky.social @lji.org @benaroyaresearch.bsky.social @stanfordimmunology.bsky.social Icahn Mt. Sinai, Seattle Childrens)
#systems #Immunology
#IDSky #immuneSky

This month's cover in Science Immunology by A. Martin ✨ Simple and beautiful use of the colors! It illustrates a fascinating study where mRNA-LNP vaccines are adjuvanted with IL-12 mRNA to boost CD8+ T cell responses and memory.
#immunesky #sciart

Congratulations to our collaborator @rrmsky.bsky.social on being named a fellow @aaas.org
#IDSky #ImmuneSky

Please enjoy using our #feed of collaborators to follow what they find interesting here.
We will routinely update with more collaborators and interested members of our network.
#ImmuneSky
bsky.app/profile/hipc...

Mapping of human monoclonal antibody responses to XBB.1.5 COVID-19 monovalent vaccines: a B cell analysis Our findings offer key molecular insights into whether strain-specific boosters elicit sufficient protection against SARS-CoV-2 emerging variants. This knowledge can inform decisions on booster design...

Our collaborators @camilahcoelho.bsky.social @vivianasimonlab.bsky.social (+ others)
show that monovalent XBB.1.5 vaccines recall mostly cross-reactive antibodies to ancestral SARS-CoV-2, not robust de novo responses.
@lancetmicrobe.bsky.social
#ImmuneSky
www.thelancet.com/journals/lan...

Durable T cell immunity to COVID-19 vaccines in MS patients on B cell depletion therapy - npj Vaccines npj Vaccines - Durable T cell immunity to COVID-19 vaccines in MS patients on B cell depletion therapy

Our collaborator Donna Farber discovers #durable #immunity for patients with #multiplesclerosis from #covid19 vaccine.
#IDSky #ImmuneSky
@donnafarber.bsky.social
www.nature.com/articles/s41...

We would like to congratulate Viviana Simon
on the Jacobi Medallion award for her long-term contributions. We value the long collaboration with her and her team. 🔬#immunity #covid19 #HIV #pandemic #virology
#ViralSky #ImmuneSky

www.youtube.com/watch?v=lJUt...

Macrophages of the Heart: Homeostasis and Disease Cardiac macrophages (CMs) are the most abundant immune cell type in the heart. They are critical for maintaining cardiac homeostasis and in the orches…

Macrophages of the #Heart: Homeostasis & Disease.

Cardiac macrophages (CMs) are the most abundant immune cell type in the heart. These heterogenous cells orchestrate #immune responses to ischemic & non-ischemic cardiomyopathies.

www.sciencedirect.com/science/arti... #OpenAccess #MedSky #ImmuneSky

Chart shows numbers of studies in data resource for Human Immunology Project consortium. more details at immunespace.org

Come get our #immune data, free #FAIRsharing is at @immportdb.bsky.social
- from @columbiauniversity.bsky.social
@icahn.bsky.social
@yalemedicine.bsky.social
@stanfordimmunology.bsky.social
@benaroyaresearch.bsky.social
@lji.org
MIT, Seattle Children's
#AAI2025
#ImmuneSky #IDsky

Mind blowing talk by Alejo Fraticelli! New techniques to understand HSC phylogeny! @alejofraticelli.bsky.social #EPW2025 #immunesky

JCI - Transcriptomic profiling after B-cell depletion reveals central and peripheral immune cell changes in multiple sclerosis

Our collaborator David Hafler + others outline central and peripheral #immune cell changes for #MS patients
#transcriptomic #Bcell
#MultipleSclerosis #autoimmune
@yalemed.bsky.social
#ImmuneSky
@jci-insight.bsky.social

www.jci.org/articles/vie...

An Allele of the MTHFR one-carbon metabolism gene predicts severity of COVID-19 While the public health burden of SARS-CoV-2 infection has lessened due to natural and vaccine-acquired immunity, the emergence of less virulent variants, and antiviral medications, COVID-19 continues...

Our collaborators identify #allele of MTHFR that increases risk of severe #COVID_19 in preprint.
Part of huge collaboration known as IMPACC. #IDSky
#ImmuneSky
@droferlevy.bsky.social @joanndarce.bsky.social @skleinstein.bsky.social @rrmsky.bsky.social
www.medrxiv.org/content/10.1...

A complicated graphic shows many different functional tests of T-cells from infants and adults, comparing their performance. Illustration from study published in BioRxiv, a preprint. Authors include Donna Farber and Peter Sims. https://t.co/u4r4k3psy7

Our collaborators @donnafarber.bsky.social and Peter Sims write about #functional analysis of #infant vs. #adult T-cells in preprint.
#immuneSKY #tissue

t.co/u4r4k3psy7

8 colored circles who different scientific assays used in #immune #studies part of Human Immunology Project. Data is free for sharing.

Go look at our #data
Free and #FAIRsharing.
144 studies, 10,244 human participants and > 135,000 samples.
#systems #immunology
@immportdb.bsky.social
#IDsky #immunesky
Check our #analysis tools at immunespace.org

immport.org/resources/hipc

Our collaborators, identified in post, plus Eu-Cheol Shin. Congrats for lining everybody up! #IDSky #ImmuneSky #systems #immunology

Poster for Cressida's talk. Abstract: The Madigan Lab seeks to understand how bacteria interact with the nervous system during infection. Several medically relevant diseases are characterized by infection of the nervous system, including TB meningitis and leprosy, which are caused by Mycobacterium tuberculosis and M. leprae, respectively. After invasion of neurological tissue, mycobacteria are thought to incite neuroinflammation, causing damage to neurons. The mechanisms at play are largely unknown. To understand the key pathological events in infections like TB meningitis and leprosy, we use an unusual model host: zebrafish larvae. The similarities between these transparent vertebrates and humans outweigh their differences: over 70% of human genes have known zebrafish orthologs. Zebrafish are amenable to infection by M. marinum, a model mycobacterial pathogen from fish. Using these resources, we track bacteria as they interact with neuroglia and cells of the immune system in the zebrafish brain in real-time. This approach revealed the mechanism by which mycobacteria cross the blood-brain barrier, which protects the brain from infection. Whereas elsewhere in the body, mycobacteria use phagocytes for dissemination, we found that only extracellular mycobacteria reach the brain microvasculature. There, they adhere to the microvascular endothelium and grow into microcolonies. These microcolonies induce endothelial cell tight junction reorganization, creating transient gaps through which bacteria enter the brain. This reorganization is induced by the mycobacterial surface glycolipid trehalose dimycolate. Strikingly, M. tuberculosis, its pathogenic relative M. marinum and the saprophyte M. smegmatis all use this same pathway for brain invasion. Thus, the zebrafish model revealed that M. tuberculosis initiates meningitis, the deadliest form of tuberculosis, using an ancestral determinant that evolved for environmental survival.

Asia-Pacific timed zebrafish infectious disease seminar *tomorrow* by Dr Cressida Madigan (UCSD) "How mycobacteria cross the blood-brain barrier"
Wednesday, 5th Feb 2025, 9:30 AM (SGT).
Registration: zoom.us/meeting/regi...
#zebrafish #idsky #mycosky #immunesky @astar-idlabs.bsky.social

How to trick the immune system into attacking tumours Nature - Lab-grown viruses make cancer cells resemble pig tissue, provoking an organ-rejection response.

How to trick the immune system into attacking tumours

Lab-grown viruses make cancer cells resemble pig tissue, provoking an organ-rejection response. #MedSky #ImmuneSky

www.nature.com/artic...
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The Virus That Breaks the Guardrails: How SARS-CoV-2 Turns the Immune System Against Us - Future of Other Infections? - Increased Cancer Risk? We moved on. The masks came off, the gatherings resumed, and the world whispered, “It’s over.” But SARS-CoV-2 never got the memo. While we returned to normal, the virus stayed busy, etching its damage into our immune systems like graffiti on an abandoned building. The wreckage it leaves isn’t always visible, but it’s there—rewiring how our bodies fight disease, setting the stage for new infections, and quietly sabotaging the systems meant to keep us safe. This isn’t just the story of a virus we think we beat; it’s the story of a virus that’s still working overtime while we look the other way. What happens when the defenses that protected us for generations start to crumble? Spoiler: the virus didn’t move on, and it’s not done with us yet. SARS-CoV-2: The Architect of Immune Chaos The virus doesn’t just waltz through the body; it dismantles t

Non-experts keep trying to convince (themselves?) others that SARS-Cov-2 has powers never seen before and will be the end of humanity as we know it.
The approach: knitting and cherry-picking. Making connections that are not there, or out of context with selected references.
#ImmuneSky #MedSky
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Strangely the k was changed to l by the spel checker!
#MedSky #ImmuneSky

Sex differences and immune correlates of Long Covid development, symptom persistence, and resolution

Multiomics approach on peripheral blood samples to correlate observations with #longcovid #immunesky #medsky

www.science.org/doi/...
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