GTSE1+ osteoblasts, enriched in #Metastatic #Osteosarcoma (OS), cross-talk with CD8+ T cells to evade #ImmuneSurveillance via the MIF-(CD74-CXCR4) axis, highlighting GTSE1 as a potential #Biomarker & #TherapeuticTarget.

#OpenAccess: doi.org/10.1016/j.ge...

Risiko durch Re-Infektionen.
-die Schäden am Gefäßsystem sind gut dokumentiert #Herzinfarkt
-ebenso Auswirkungen auf Nervensystem und Hirn #brainfog
-die Schwächung des #Immunsystems könnte sogar Krebsentstehung fördern #ImmuneSurveillance
Trotzdem wird die #Impfung verdammt, 2/3

Immune evasion in cancer: mechanisms and cutting-edge therapeutic approaches

A comprehensive review detailing how #tumors evade #ImmuneSurveillance through immune suppression, checkpoint regulation, genetic/epigenetic changes, TME dynamics, and metabolic reprogramming, while highlighting challenges in current #immunotherapy. #medsky

#STTT #OpenAccess: buff.ly/2sIlld8

6/n
Why don’t most p53 signatures progress to cancer — even though they're common?

💡 Because the immune system is already at work. Innate immune players (NK–cDC1–CTL axis) and tissue-resident memory T cells help keep early lesions in check.

#ImmuneSurveillance matters!

6/n
Why don’t most p53 signatures progress to cancer — even though they're common?

💡 Because the immune system is already at work. Innate immune players (NK–cDC1–CTL axis) and tissue-resident memory T cells help keep early lesions in check.

#ImmuneSurveillance matters!