Acetylation K1039 of DNA polymerase γ/Polγ (mitochondrial DNA polymerase) in Smooth Muscle Cell▶️
⏬mtDNA binding
⏬Mitochondrial function (JC-10)
⏬Contractility, L-type Ca²⁺ channel, TRPC6
⏫Proliferation

Polγ as a deacetylase substrate of GCN5-SIRT3

#IntJBiolSci 2026
www.ijbs.com/v22p2435.htm

#SpatialTranscriptomics #Visium (n=2) human #UterineLeiomyoma
+snRNAseq

Tumor vs Pseudocapsule vs Myometrium

5 ACTA2+ACTG2+ #SmoothMuscleCell states
3 PDGFRB+NOTCH3+ #Pericyte states
Love to see more analysis...🤓

ERβ⏫in angiogenic #EndothelialCell

#IntJBiolSci 2023
www.ijbs.com/v19p2515.htm

#Colchicine stabilizes #SmoothMuscleCell contractile phenotype & alleviates🐭#AbdominalAorticAneurysm (local CaPO4)
ep.2

Colchicine
⏬METTL14-YTHDC1-m6A modification➡️
⏫Sclerostin (BMPi) mRNA stability➡️
⏬Wnt/β-cat

👤#AAA
lesional SMC ⏫METTL14 ⏫β-cat ⏬SOST

#IntJBiolSci 2024
www.ijbs.com/v20p2092.htm

Recombinant Endosialin (aka CD248/TEM1) i.p alleviates🐭 #AbdominalAorticAneurysm (CaCl2 or ANG II)

In👤aortic #SmoothMuscleCell Fibroblast, rEndosialin⏫TGFβ1/SMAD2 & Collagen deposition

Endosialin⏫in AAA, enriched in SMC/Fibroblast/Monocyte

#IntJBiolSci 2024
www.ijbs.com/v20p3691.htm

Can Erastin induce #AorticAneurysm/#AorticDissection?🤔
No straightforward answer yet

But take a read of this👇
#IntJBiolSci 2022
www.ijbs.com/v18p4118.htm

Liproxstatin-1, a ferroptosis inhibitor,⏬BAPN-induced ferroptosis+🐭#AorticDissection

3/3
Context-specific roles of Limb Bud and Heart in tumor #Angiogenesis

#Glioma
LBH as a HIF1 target gene⏫#Angiogenesis
@eBioMedicine 2019
linkinghub.elsevier.com/retrieve/pii...

#NasopharyngealCarcinoma
LBH⏬VEGFA secretion by tumor⏬#Angiogenesis
#IntJBiolSci 2022
www.ijbs.com/v18p0242.htm